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I Example of the AEGL Derivation Summary Appendix in a Technical Support Document
Pages 196-200

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From page 196...
... AEGL-1 Values 30min 1 lh 1 4h Not Not Not re c ommende d re c ommende d re c ommende d Reference: Not applicable Test Species/Strain/Number: Not applicable Exposure Route/Concentrations/Durations: Not applicable Effects: Not applicable Endpoint/Concentration/Rationale: Not applicable 8 h Not recommended (Continued)
From page 197...
... Effect 360 ppm muscle fasciculations in 1 of 4 dogs (determinant for AEGL-2) 400 ppm behavioral changes in 2 of 4 dogs 1,530 ppm tremors, convulsions, vomiting in 2 of 2 dogs Endpoint/Concentration/Rationale: 15-min exposure at 360 ppm considered a threshold for potentially irreversible effects or effects that would impair escape.
From page 198...
... Data Adequacy: Information regarding the human experience for acute inhalation exposure to dimethylhydrazine are limited to qualitatively case reports indicating nasal and respiratory tract irritation, breathing difficulties, and nausea. Data in animals have shown concentration-dependent effects ranging from respiratory tract irritation, pulmonary edema and neurologic effects to lethality.
From page 199...
... Based upon these data, it was assumed that humans may be equally variable in their response to dimethylhydrazine subsequent to similar stresses. Modifying Factor: None Animal to Human Dosimetric Adjustment: None applied, insuff~cient data 1 8h
From page 200...
... Data Adequacy: Information regarding the lethality of dimethylhydrazine in humans were not available. Lethality data for several animal species allowed for a defensible development of the AEGL-3 values but uncertainties remain regarding individual variability in the toxic response to dimethylhydrazines.


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