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Biographical Memoirs Volume 79 (2001) / Chapter Skim
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Rafael Lorente De No
Pages 84-105

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From page 85...
... While Lorente cle No pioneered discoveries in many areas, he wished foremost to be remembered for his work in neurophysiology. He contributecl to unclerstancling mechanisms of nerve cell communication, potassium channel function, functional organization of the brain stem, neuronal activation through multiple reentrant and parallel pathways, the hippocampus, and 85
From page 86...
... without attribution. PERSONAL HISTORY Rafael Lorente cle No (callecl Lorente, Dr.
From page 87...
... to the American Academy of Arts en c! Sciences en cl was awarclecl honorary degrees by the University of Uppsala, Clark University, and Rockefeller University.
From page 88...
... to Zaragoza expressly to hear Professor Robert Barany of the University of Uppsala, who served as a visiting professor for several weeks at the meclical school. (Barany won the ~ 9 ~ 4 Nobel Prize "for his work on the physiology and pathology of the vestibular apparatus.")
From page 89...
... Discoveries using the cathode ray oscilloscope Termed the "inertia-less smoke cirum" by William Lanciau) in the late 1920s by Joseph ErIanger, Herbert Gasser, en cl George Bishop, later joiner!
From page 90...
... E Astrom's anatomical studies on the cranial nerve nuclei in the mouse brain stem.
From page 91...
... an accurate picture of the complexities of the unclerlying structures. He participatecl in the debates concerning the nature of synaptic transmission (1940~.
From page 92...
... (This work stoocl for nearly two clecacles as the authoritative source about the organization en cl function of brain stem vestibular nuclei.) He observed persistence of vestibular activation of eye movements after midline section of the brain stem to cut inputs
From page 93...
... nerve suggesting that there was preservation of topography en cl function from the end organs in the target nuclei (1933~.~° The importance of Lorente's unclerstancling of the role of the brain stem reticular formation was emphasized by Ann Graybiel at a 1978 tribute helcl at the Rockefeller (see Gooc~hill's foreword to The Primary Acoustic Nuclei ~ ~ 98 ~ ~ ~ . With Helen Treac~way Graham, he clevelopecl electrophysiological skills in studies of cranial motor neurons in the ocuTomotor, trochicar, en c!
From page 94...
... en c! clescribecl neuronal cell types in the mouse cortex with Golgi's method that were at least as rich as clescribecl in Cajal's earlier account of the human cortex.
From page 95...
... Louis, Lorente cle No published the cellular architecture en cl Golgi stained cells of the entorhinal cortex (1933)
From page 96...
... . enters in a refractory state, but the cell body and dendrites do not do so, they continue receiving and adding subliminal changes until the threshold value is reached again and the axon has recovered.
From page 97...
... I first came across Lorente's work in the summer of 1966 as I was reacting the literature on the architectonics of the mouse brain.~7 Lorente's paper figured prominently in the discussion of M Rose's stucly of the cytoarchitecture of the mouse cortex, a copy of which I had at the University of Wisconsin.
From page 98...
... It is thanks to Lawrence Kruger at UCLA that I actually got to meet Lorente in Los Angeles nearly nine years later. Short in stature, Lorente was an urbane, charming, en cl inquisitive man exciter!
From page 99...
... My wife, Cincly, as she elegantly en cl so often does, quickly expanded the planned dinner party to inclucle acquaintances from Lorente's St. Louis clays en cl other colleagues of long stancling then living in St.
From page 100...
... The list is incleecl diverse en cl impressive. Perhaps it is for this reason that it is so clifficult to fully comprehend Rafael Lorente cle No's extraordinary impact on science.
From page 101...
... Hillel The inner quaternary ammonium ion receptor in potassium channels of the node of Ranvier.
From page 102...
... Rose. Cytoarchitektonischer Atlas der Grosshirnrinde der Mans.
From page 103...
... Ein Beitrag zur Kenntnis der Gefassverteilung in der Hirnrinde. Journal fur Psychologie und Neurologie 35:19-27.
From page 104...
... iournal of Neurophysiology 1 :207-44. The cerebral cortex: Architecture, intracortical connections and motor projections.
From page 105...
... Part I, 131:1-496; Part II, 132:1-548. 1949 On the effect of certain quaternary ammonium ions upon frog nerve.


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