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Immunization Safety Review Thimerosal-Containing Vaccines and Neurodevelopmental Disorders (2001) / Chapter Skim
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The Study Process
The Framework for Assessing Causality
Pages 23-26

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From page 23...
... Unpublished data shared with the committee through presentations and personal communications helped inform the committee's conclusions and recommendations. THE FRAMEWORK FOR ASSESSING CAUSALITY The Immunization Safety Review Committee has adopted the framework for assessing causality developed by the committees previously convened by the IOM (1991a, 1994a)
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From page 24...
... The Immunization Safety Review Committee is using the wording adopted in 1994. The sources of evidence considered by the committee in its plausibility assessment include epidemiological studies, reports of individual cases or series of cases, and studies related to biological plausibility.
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From page 25...
... Preventive Services Task Force, 1996~. However, the Immunization Safety Review Committee was convened specifically to assess topics that are usually of immediate and intense concern.
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From page 26...
... Evidence The evidence indicates a establishes a causal relation causal relation Epidemiological studies and/or case reports provide unequivocal evidence for a causal relation.
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  • regarding biological
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  • rigorous peer

  • published literature
  • favors acceptance
  • defined sample
  • provides evidence
  • associated terminology

  • studies related
  • address questions
  • personal communications
  • advisory groupies
  • assess topics

  • data reviewed
  • provide unequivocal
  • convened specifically
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  • obtained using


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