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VI Lung-Cancer Histopathology
Pages 497-503

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From page 497...
... Numerous classification schemes have been published, with the most widely used being that developed by the World Health Organization and recently modified.25 The accuracy of histopathological diagnoses is influenced by the quantity and quality of the tissue available for examination. Observer variability in the classification of lung-cancer histopathology has been well documented and may be of substantial magnitude.~4 Reliance on clinical reports may introduce substantial misclassification.
From page 498...
... Autopsy specimens from miners in nearby Joachunsthal showed a preponderance of small-cell carcinomas.~7~23 A later investigation of uranium miners in this same area showed that small-cell cancer remained the most common histological type. Horacek et al.~3 compared the histological distribution of 115 cases of lung cancer in Czechoslovakian uranium miners with that in 326 control cases.
From page 499...
... 4gg Smog CeD Age Cell Adenocarcinoma Mucous CeD FIGURE VI-1 "~tob~c~ typee of lung cancer SOURCE: Jonstban Saw, unit verity of New Delco, persona com~nic~lon, 1987.
From page 500...
... Boo BARTH RISKS OF RADON AND OTHER ALPHA-EMIlUTERS TABLE VI-1 Lung-Cancer Histopathology in Mining Groups Exposed to Radon Daughters Population Joachimsthal miners '7 23 Findingsa Comment Colorado Plateau uranium miners ~,4,~9,20,2~ Newfoundland fluorspar miners26 British iron ore minersS Swedish iron ore miners Swedish iron ore miners9 Czechoslovakian uranium miners Canadian uranium miners Navajo uranium miners Navajo uranium miners7 28 cases: 16 SCC, 12 squamous SCC predominance, increasing with WLM 29 cases: 26 squamous, 2 SCC, 1 adenocarcinoma 69 cases; 27 SCC 36 cases: 26 SCC, 10 squamous 25 cases: 11 SCC, 11 squamous, 3 adenocarcinoma 115 cases: 62 SCC, 40 squamous, 4 adenocarcinoma, 9 other types 91 cases; 47 SCC 16 cases: 10 SCC, 3 squamous, 3 other types 21 cases: 7 SCC, 8 squamous, 4 adenocarcinoma, 2 LCC Autopsies 1929-1930 and 1933-1938; one pathologist Cases seen at specific hospitals; panel review All cases diagnosed by sputum cytology Histologic type from pathology report Histologic type from Swedish cancer registry Methods not given One pathologist Selected from 134 cases; histologic type from pathology report Methods not given; histologic type from pathology report Panel review New Mexico uranium 45 cases: 28 SCC, Panel review miners6 15 squamous, 1 adenocarcinoma, 1 LCC Abbreviations: SCC, small-cell carcinoma; LCC, large-cell carcinoma; Squamous, squamous cell carcinoma.
From page 501...
... Navajo miners who worked in the Colorado Plateau are of interest because only a small proportion smoked cigarettes, with average consumption by the smokers of only a few cigarettes each day.4~22 Gottlieb and Husenit described 16 Navajo miners diagnosed with lung cancer at the Shiprock Indian Health Service Hospital from 1965 through 1979. Based on record review, they reported that 10 of the cases were small-cell carcinomas.
From page 502...
... 1964. Considerations statistiques sur la cancer bronchique du mineur de fer du bassin de la Lorraine.
From page 503...
... 1982. The World Health Organization Histological Typing of Lung Tumors, 2nd ed.


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