Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids (2005) / Chapter Skim
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14 A Research Agenda The Panel on Macronutrients and the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes were charged with developing a research agenda to provide a basis for public-policy decisions related to recommended intakes of energy, fat, carbohydrate, and protein. This chapter describes the approach used to develop the research agenda, briefly summarizes gaps in knowledge, and presents a prioritized research agenda.
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For some macronutrients, such as indispensable amino acids, more data are needed using clinical endpoints or intermediate endpoints of impaired function to determine their requirements in regard to long-term health. For determining energy requirements, more information is needed on the form, frequency, intensity, and duration of exercise that is consistent with a healthy body weight for all age groups.
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Long-term clinical trials are needed to further understand the role of glycemic index in the prevention of chronic disease. Adverse Effects There is a body of evidence to suggest that high intakes of total fat, saturated fatty acids, trans fatty acids, and cholesterol increase the risk of adverse health effects (e.g., elevated low-density lipoprotein [LDL]
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From page 971... ...
The following five areas for research were assigned the highest priority (other research recommendations are found at the ends of Chapters 5 through 10 and Chapter 12) : · Doseresponse studies to help identify the requirements of macronutrients that are essential in the diet (e.g., indispensable amino acids and n-6 and n-3 polyunsaturated fatty acids)
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