Guide for the Care and Use of Laboratory Animals -- Russian Version (2018) / Chapter Skim
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Chapter 2
Chapter 2
Pages 23-60
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From page 23... ...
e lI03BO3ISIeT CBeCTlI ~0 M~HUMyMa H3MeHeH~, KOTOpLIe MOryT OTpa3HTBCH Ha pe3y~BTaTaX Hay~H~X ~CC~e~OBaHHH.
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From page 24... ...
~eHHeM7 cpe~a 06HTaHUSI B HepBHUHOM Orpa)
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From page 25... ...
HEIMn rIOBepXHOCTHMH; He lIMeIOT OCTpLIX KpaeB ~H BBICTyHOB, KOTOpLIe MOryT TpaBM~pOBaTB ~BoTHoe; '~aIoT B03MO*
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From page 26... ...
eH paCCMaTpUBaTBCH IACUC C TOlI TOIIKlI 3peHlISI, IITO lIpaBlIJIBHO H0~0 JpaHHEIe K~eTKH ~O~* HEI crIocodcTsosaTB 6~arorIo~y~nIo ~BOTHEIX, C06~IO~eHUIO CaHUTapHEIX HOpM ~ yCTIeIIIHOMy BBIHO~HeHUIO 3KCHepUMeHTOB.
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From page 27... ...
HO y6HpaTB ~H 3aMeHSITB Ho Mepe HeO6XO~HMOCTH ~~H C06~IO~eHH~ COOTBeTCTByIO~UX CaHUTapHEIX HOpM.
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From page 28... ...
, yKp~THU (HaTIplIMep, HeKOTOpLIe lIplIMaTLI HOBOrO CBeTa)
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From page 29... ...
e 3a~aHax, KoTopLIe CTaBSITCSI lIplI lIX pa3MemeHnn.
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From page 30... ...
30 PYKOBO~CTBO no CO~EP2KAHlIlO BBC77O!
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From page 31... ...
~H HeKOTOpbIX co6aK' oco6eHHo ,~H oco6en, IIpH6~3KalO~nXCH K BepXHen rpaHuLle ~ ~ HOpMbI B Ka~OlI BeCOBOlI KaTerOplIlI, MO) KeT HOHa~O HTbCH JO~b~e MeCTa, B cooTBeTcTBHn C 3aKoHoM O 6~arococToRHHn ~K~BOTHbIX (Animal Wefare Act)
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From page 32... ...
K ~aKTOpaM, KOTOpLIe MOryT CHOC06CTBOBaTB KO~e6aHH~M TeMlIepaTypLI ~ B~a* HOCTH, OTHOCHTCH KOHCTpyK~ ~ MaTepHa~BI, H3 KOTOpLIX lI3rOTOB3IeHEI orpa~eH~, ncuo~B30saHne ~BTpa c Ha~CTaBKOH, KO~eCTBO *
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From page 33... ...
YC:11OBE! CO~EP2KAH~IBOTHLIX 33 Ta6JInua 2.3 PeKoMeH,~yeMme pa3Mepu orpa;K,D;eHnn WIN 06MlIHO ~CrIOJIB3yeM~X Ce~BCKOXO3~HCTBeHHLIX ~~dBOTHLIX KO~-BO ~BOTHbIX B OrPa~eHHU Macca, Kr a IIJIOILIa,0;b IIOBepXHOCTlI Ha O~HO~BOTHOe, ~yT26 OBUM ~ KOOK: 2-5 >5 CB~HbH: 2-5 >5 KPYIIHMU POraTMU CKOT: 2-5 >5 <25 HO 50 > 50 <25 HO 50 > 50 <25 HO 50 > 50 < 15 HO 25 HO 50 HO 100 HO 200 > 200 <25 HO 50 HO 100 HO 200 > 200 <25 HO 50 HO 100 HO 200 > 200 <75 HO 200 HO 350 HO 500 HO 650 > 650 <75 HO 200 HO 350 HO 500 HO 650 > 650 <75 HO 200 HO 350 HO 500 HO 650 > 650 0,0 15,0 20,0 8,5 2,5 7,0 7,5 ,3 5,0 8,0 2,0 15,0 24,0 48,0 >60,0 6,0 10,0 20,0 40,0 >52,0 6,0 9,0 18,0 36,0 >48,0 24,0 48,0 72,0 96,0 24,0 44,0 20,0 40,0 60,0 80,0 05,0 20,0 18,0 36,0 54,0 72,0 93,0 _ 108,0
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From page 34... ...
34 PYKOBO~CTBO no CO~EP~AHBlO BBC770!
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From page 35... ...
, KOTOpLIe MOryT CO~ep~aTBCH B ~aHHOM HOMe~eHHH.
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From page 36... ...
Echo pace M~HuMyM OKasuBaeTCH Cy~eCTBeHHO Hoe lo-KpaTHon CMeHM Bos'~yXa B Sac, Toga MO* eT rIoTpe6osaTBcH cos'~aHHe Belt C tree HHaKOn CKOpOCTBlO BO BTOp~HOM orpa;K'D;eHHn rIpH yC3IOBlIlI, IITO TaKaSI BeHT~q~ He HpUBe~eT K HaKO~eHHIO Bpe,~HuX ~n HerIpHeM~eM~X KOHLleHTpaLlHn TOKCHIIeCKHX rasos' sarIaxos ~n TBep,~MX lIpUMeCen B rIepB~HOM Orpa;K,D;eHHH.
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From page 37... ...
e H03BO~HeT CHH3HTB KOH~eHTpa~HIO TOKCIIIIeCKlIX lIJIlI CIIJIBHO HaXHyILlUX ra30B B aTMOC~epe HOMe~eHHH. o6pa6oTKa pe~HpKy~Hpylo~ero Bo3~yxa c ~e~Io y~a~eHH~ TBep~BIx H~n - ~ ~ ~ ra300 Jpa3HEIx rIpuMecen ~B~HeTcH ~oporocToH~en rIpoLle'~ypon ~ Mo~eT OKa3aTBCH He3~eKTHBHOH B c~yHae HenpaBH~BHoro H~n Hea~eKBaTHoro 06C~y~BaH~ ~BTpa~HOHHEIX CHCTeM.
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From page 38... ...
Ha 6MTB BM6paHa TaK~M o6pa3oM, HTo6M He oTpa~aTBcH Ha UX COCTO~HHH. '~H o6ecrIeHeHH~ pery~HpHoro cyTo~Horo ~nK~a ocse~eHH c~e,~yeT lICTIO3IB30BaTB aBTOMaTHHeCKHe CHCTeMBI B~IOHeHHH/BBIK~IOHeHH CBeTa ~ rIepno,~ecKu rIpOBepSITE paboTy TauMepa.
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From page 39... ...
HO BOCHO~B30BaTBCH pyKOBO~CTBOM 06mecTsa UH* eHepOB-CBeTOTeXH~KOB CesepHon AMep~Ku (Illuminating Engineering Society of North America IESNA)
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From page 40... ...
HBOTHEIX HpH HpOeKTHpOBaHHU BUBapHH. Bos~encTsue myMa c yposHeM nHTeHcusHocTu, rIpes~ImaIomuM 85 ~E, Mo~eT oKasaT~ s~Hne KaK Ha c~yxoson ar~r~apaT' TaK ~ Ha ~pyrne opraH~I [Fletcher, 1976; Peterson, 1980i, s~Issas aosuHorIeHnIo ~ yse~eHne Macc~ Ha~rIolIelIH~Kos y rp~I3yHos [Geber et al., 1966; Nayfield, Besch, 1981i, cHn~eHne ~epT~BHocTn y rp~IsyHos [Zondek, Tamari, 1964]
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From page 41... ...
K,D;y ~BOTH~MU PHOTO Baja (KOHCHe~HMe *
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From page 42... ...
,~JI~ KpyrIHEIX ceJIBcKoxo3HucTBeHHEIx ~UBOTHEIX, HarIpUMep OBeLl, JIoIIIa'~eu -u- KpyrIHOrO poraToro CKOTa, CJIe~yeT u-MeTB rIpOCTOpHEIe 3aroHEI, IIJIOILla~KU ~H TpeHUpOBKU U nacT6Uma.
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From page 43... ...
~pUMeCH B KOpMOBBIX HpO~yKTaX MOryT oKa3aT~ CH~EHoe B~HS[HHe Ha 6nox~Mu~ecKne ~ ~3~0~0rn~ecKne rIpoL~ecc~I, ,~a~e ec~n OHlI lIplICyTCTByIOT B TaKHX HH3KHX KOH~eHTpa~X, KOTOpLIe He MOryT BBI3BaTB ~HH~eCKHe CHMUTOMBI TOKC~eCKHX HOpa~eHHH. HaTIpUMep, HeKOTOpLIe HpUMeCH UH~y~HpyIOT CHHTe3 ~epMeHTOB ne~eHn, KOTOpLIe MOryT H3MeHUTB peaK~HIO opraHn3Ma *
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From page 44... ...
KoHTenHepLI C XpaHR~HMCH B HuX KOpMOM He~B3H rIepeHocHTB lIepe3 30HEI, oT~aIo~HecH rIOBBIIIIeHHEIM puCKOM KOHTaM~HaLlHH; rIpH 3TOM KOHTenHepLI Hy* HO peryMqpHO HUCTHTB ~ HO~BepraTB CaHUTapHOH 06pa60TKe.
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From page 45... ...
Heo6xo~uMo csecTn no M~HUMyMa pe3KHe H3MeHeHH~ B panache HUTaH~ (KOTOp~X Tpy~HO H36e~aTB HpH OT~eMe OT MaTep~HCKOrO MO3IOKa) , lIOCKO3IBKy OHM MOryT HpUBeCTH K HH~eBapUTe~BHEIM ~ MeTa60~eCK~M Hapy~eH~M; r~o,~o6Hme Hapy~eH~ OTMeHalOTCH y BCe~H~X OTOSI,D;H~X ~BOTH~X, HO came scero scTpe~a~oTc~ y Tpaso~Hux [Eadie, Mann, 1970~.
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From page 46... ...
r~pe~cTasu~n or~ncaHne ~e~aTe~BH~X XapaKTepUCT~K ~ MeTO~OB O~eHKH KaHeCTBa HO~CT~a. ~aCTO lICTIO3IB3yeTCH HO~CTH~, H3rOTOB~eHHMU Ha M~rKon ~pesec~Hu; o~HaKo HpUMeHeHHe Heo6pa60TaHH~X CTpy~eK ~ OHH~OK He peKOMeH~yeTCH HpH BLITIO3IHeHlIlI OlIpe~e~eHH~X ~CC~e~OBaHHU, TaK KaK OHS MOryT OKa3aTB Bee Ha MeTa60~3M *
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From page 47... ...
C ,~pyron CTOpOHEI, HpH SIX HpUMeHeHHU ~BOTHEIe ~CHEITEIBaIOT B03~eUCTBUe ~eTy~UX COe~HHeHHU, KOTOpLIe MOryT HpUBeCTH K H3MeHeHUIO OCHOBHEIX ~0~0r~ecKnx ~ MeTabo~ecKnx r~poucccos. C~eua nodcmu~a r ~ ~ ; arpSI3HeHHEIU HO~CT~O~HEIU MaTepHa~ c~e~yeT y~a~HTE ~ 3aMeH~TE CBe*
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From page 48... ...
IlpH ~CHO~B30BaHHU CHCTeMBI aBTOMaT~eCKHX HO~OK peKOMeH~yeTCH lIpe~yCMOTpeTB cHoco6 y~a~eH~ M~KpOOpraHH3MOB ~ MyCOpa, KOTOpLIe MOryT B HUX HaKa~HBaTBCH.
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From page 49... ...
nsoTHme, BCTIOMOraTe3IBHEIe HOMe~eH~ (TaKHe KaK c~a~cKne HOMe~eH~, MOe~HEIe H 06pa60TKH K~eTOK, KOpH~OpLI ~ HpO~e~ypHEIe) , Tpe6yIOT pery~HpHOH y60pKH lo, B 3aBUCHMOCTH OT 06CToSITe~BCTB, ~e3HH~eK~H C HaCTOTOH, orIpe,~e~eMon xapaKTepoM lICrIO3IB30BaH~ TaKHX noMemeHnn ~ HpUpO~OH OX BepOSITHOlI KOHTaMlIHa~.
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From page 50... ...
HBOTHEIM~, KOTOpLIe MOryT 6BITB HO~BeprHyTEI UX B03~eUCTBUIO.
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From page 51... ...
HBOTHEIX, COCTaBJIHeTCH KaK HacTB o6~en rIporpaMMBI o6ecrIeHeHH~ 6e3orIacHocTH BuBapHH.
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From page 52... ...
LteHHyIo HOMONYM MOryT TaK*
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From page 53... ...
1985. Chronic noise stress and insulin secretion in male rats.
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From page 54... ...
1995. Behavioral responses of longtailed macaques to different cage sizes and common laboratory experiences.
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From page 55... ...
1972. International standardized nomenclature for outbred stocks of laboratory animals.
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From page 56... ...
1980. Genetic quality control of laboratory animals with emphasis on genetic monitoring.
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From page 57... ...
1975. Influence on pharmacological experiments of chemicals and other factors in diets of laboratory animals.
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From page 58... ...
Psychological Well-being of Nonhuman Primates. A report of the Institute of Laboratory Animal Resources Committee on Well-being of Nonhuman Primates.
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From page 59... ...
1976. Environmental and genetic factors affecting response of laboratory animals to drugs.
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From page 60... ...
1991. Recent trends in genetic research on captive and wild nonhuman primate populations.
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Key Terms
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