Immunodeficient Rodents A Guide to Their Immunobiology, Husbandry, and Use (1989) / Chapter Skim
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3 INDUCED IMMUNODEFICIENCIES
3 INDUCED IMMUNODEFICIENCIES
Pages 140-147
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From page 140... ...
and polybrominated biphenyls (PBBs) , for example, have been shown to generally impair immune responsiveness, and Tris depresses cell-mediated immunity (Luster et al., 19871.
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From page 141... ...
Lead-treated animals express decreased PMN phagocytic activity, and immunoglobulin and complement responses are reduced when lead-treated animals are subjected to active immunization regimens. Lead appears to block complement receptors on B lymphocytes (Koller and Brauner, 19771; however, lead does not significantly alter MLC responsiveness (Koller and Roan, 1980)
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From page 142... ...
An immunoinhibitory role of glucocorticoids has been suggested from the observations that in rodents, thymic atrophy results from the administration of exogenous glucocorticoids or from prolonged stress (Stein, 19851. Although the effect of glucocorticoids on murine and guinea pig lymphocytes is much greater than that seen in humans, there is ample evidence that glucocorticoids have some inhibitory activity in all mammalian species studied (Claman, 1972; Calvano, 19861.
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From page 143... ...
These macrophages expressed increased tumor cell killing activity and had highly convoluted cell membranes. Mouse thymic virus, an uncommon herpesvirus that attacks the thymus gland of neonates causing severe thymocyte necrosis, diminishes the reactivity of spleen cells to T-cell mitogens and allogeneic cells.
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From page 144... ...
Radiation biologists who used this technique soon found that lethally or sublethally irradiated mice died more quickly than expected if Pseudomonas aeruginosa was present in the oral cavity or gastrointestinal tract. Furthermore, mice maintained under conventional conditions exhibited a wide variation in morbidity and mortality when they were exposed to total lymphoid
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From page 145... ...
Allograft survival approaches five times the control value following TLI, is about two times the control value if the thymus is shielded during irradiation, and is lower still if only the thymus is irradiated (Slavin et al., 19771. Antibody response to SRBCs is eliminated for about 1 month following TLI.
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From page 146... ...
Male mice thymectomized on the third postnatal day develop spontaneous autoimmune prostatitis at puberty by autosensitization to antigens that are normally expressed during prostate differentiation (Taguchi et al., 19851. The study of neonatally thymectomized mice has been instrumental in delineating the T- and B-cell systems.
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From page 147... ...
Thymectomized mice inoculated with ectromelia virus developed a fatal, generalized infection (Allison, 19741. Likewise, thymectomized mice inoculated with herpes simplex virus type 1 developed fatal encephalitis (Mori et al., 1967~.
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