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Immunodeficient Rodents A Guide to Their Immunobiology, Husbandry, and Use (1989) / Chapter Skim
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6 GENETIC MECHANISMS GOVERNING RESISTANCE OR SUSCEPTIBILITY . . .
Pages 161-164

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From page 161...
... Various strains of mice are known to differ in their susceptibilities to naturally occurring viral agents such as Sendai, ectromelia, polyoma, and lactic dehydrogenase viruses (Bang and Warwick, 1960; Chang and Hildemann, 1964; Kees and Blanden, 1976; Martinez et al., 19801. Strain differences are also observed in their susceptibilities to such experimental virus infections as herpes simplex type 1, influenza A, measles, and flaviviruses 161
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From page 162...
... The demyelinating disease is largely caused by a T-cell-mediated delayed-type hypersensitivity reaction against brain tissue. Adoptive transfer from diseased LEW rats of lymphocytes restimulated in vitro with basic myelin protein leads to lesions resembling an experimental allergic encephalomyelitis in recipients (Watanabe et al., 19831.
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From page 163...
... BALB/c mice carry genes that impart protection against lethal encephalomyocarditis virus infection by influencing the action of interferon (Dandoy et al., 19821. In C3H/RV mice, however, an autosomal dominant gene confers resistance to flavivirus infection that is independent of interferon action (Brinton et al., 19821.
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From page 164...
... This gene, Ihe-l, was not linked to genes controlling resistance to Taenia teaniaformis, Giardia muris, Trichuris muris, or Nematospiroides dubius. Although the mechanisms controlling resistance and susceptibility to the agents listed above are, for the most part, undefined, it is known that they do not involve specific immunity.
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Key Terms

  • demyelinating disease
  • specific immunity
  • controlling resistance
  • lew rats
  • herpes simplex

  • dominant gene
  • inbred strains
  • jhm strain
  • infectious agents
  • dominant trait

  • ectromelia virus
  • genes controlling
  • disease associated
  • disease caused
  • murine resistance

  • virus infection
  • confers resistance
  • blastomyces dermatitidis
  • control various
  • macrophage activity

  • mice carry
  • lactic dehydrogenase
  • macrophage function
  • substances interferon
  • lps loci

  • clinical illness
  • hormone status
  • seven times
  • sendai virus
  • mechanisms controlling


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