Immunodeficient Rodents A Guide to Their Immunobiology, Husbandry, and Use (1989) / Chapter Skim
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GLOSSARY
GLOSSARY
Pages 217-232
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From page 217... ...
. A specially prepared serum containing Sources used to compile this glossary include the following: Blakiston's Gould Medical Dictionary, 3d ea., McGraw-Hill Book Co., New York, 1,828 pp., 1972.
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. An autoantibody frequently seen in patients with systemic lupus erythematosus and certain related connective tissue diseases.
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A calcitoninlike substance has also been extracted from porcine adrenal glands. In hypercalcemia the hormone rapidly lowers blood calcium by inhibiting bone resorption; it also increases urinary excretion of phosphate.
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Any one of a group of at least nine factors, designated C1, C2, etc., that occur in the serum of normal animals and enter into various immunologic reactions. Complement is generally absorbed by combinations of antigen and antibody and, with the appropriate antibody, can lyse erythrocytes, kill or lyse bacteria, enhance phagocytosis and immune adherence, and exert other effects.
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. A nonsteroid estrogen used as a substitute for the natural estrogenic hormones, it is more readily absorbed from the alimentary canal than most of the natural hormones and hence is suitable for oral use.
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O ~ ' - - -- J _ ~ _ _ = ~_ ~ ^ terlzed by donor (grafted) lymphocytes attacking host cells based on the recognition of histocompatibility antigens on host cells not present on the donor lymphocytes and the inability of host lymphocytes to reject the donor cells.
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It is also a growth factor for mast cells.
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This hormone also enhances the cytolytic activity of cytotoxic T cells and is a mast cell growth factor. IL-6 (Interleukin-64.
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A phagocytic cell that is found in many tissues, that is a blood monocyte, and that has an important role in host MALT (Mucosal-Associated Lymphoid Tissue)
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A multimolecular complex formed by the activation of the terminal components of the complement pathway and responsible for cytolysis. MHC (Major Histocompatibility Complex)
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Parathyroid Hormone. A polypeptide hormone in parathyroid glands that regulates blood calcium levels.
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Recombinant Inbred. A strain formed by crossing two inbred strains, followed by 20 or more generations of brother x sister mating.
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Individuals or tissues that have identical genotypes, for example, animals of the same inbred strain. SLE (Systemic Lupus Erythematosus)
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. The antigen receptor of T cells composed of two polypeptide chains and closely associated with the T3 surface membrane molecules.
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Wild Type. Of or relating to a genetic locus or an allele that specifies a phenotype that predominates in natural populations or that is designated as normal.
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