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From page 233... ... Index A Adaptive immune system/mechanisms, 2-10, 224 Adenosine deaminase, 85, 217; see also Severe combined immunodeficiency p-Adrenergic substances, 10 Allergic contact dermatitis, 81, 220 Alopecia, 57, 116; see also Mouse mutants nu; Rat mutants, rnu Amyloidosis, 116, 119, 122, 218 Antigens Anemia autoimmune hemolytic, 88, 97, 105- 106, 112, 220 defined, 218 macrocytic, 82-83 in osteopetrotic mutations, 51, 68 Antibiotics, and immunosuppression, 12 Antibodies anti-class II MHC, 132 anti-DNP, 135, 218 antihistone, 115 antinuclear, 50, 54, 61, 70, 88, 94, 99, 109, 114, 115, 122, 218 B cell production of, 3 deficiency in LPS-induced adjuvant response to, 63 enhanced production of, 142 function of, 3-4, 10 233 genetic mechanisms in diversification of, 6-7 T-cell-dependent responses, 140-141, 142 T-cell independent responses, 140- 141 thymocyte-binding, 88 viral inhibition of, 13 see also Autoantibodies; Immunoglobulins Antibody-dependent cytotoxic cells, 10, 217 Brucella, 50 defective responses to, 115, 116, 135, 136 designations, 2 IaW39, 86 I-E surface, 101 monoclonal antibodies reacting to, 213-215 resistance to tolerance induction by, 119 retroviral gp70, 108, 112 T-cell dependent, 116, 135- 137 T-cell independent, 116, 230 thymus-dependent, 85, 115, 230 thymus-independent, 85, 230 thyroid-stimulating hormone receptor (TSH) , 14 see also Major histocompatibility complex antigens Read the entire page →
From page 234... ... , 106 reduced levels of, 91 thymus-binding, 54, 227 Autoimmunity/autoimmuine disease acceleration of, 87-89, 91, 93-94, 97, 112 autoantibodies characteristic of, 14 autoimmune polyendocrine disease, 14 B cell depletion and, 94 correction of, 107-108 defined, 2, 218 early-onset lymphoid hyperplasia with, 52 environmental factors in, 13-14 estrogen therapy and, 99 experimental autoimmune encephalomyelitis B cells (EAE) , 95, 117-118, 120, 221 genes controlling susceptibility to, 105, 161 hemolytic anemia, 105 induced by MHV, 162 Ly-1+ B cell population and, 66 modification of natural history, 86-87 orchiectomy and, 88 progressive auto~mmune lymphoproliferative disease, 94 spontaneous, 13-14, 70, 101, 105 systemic lupus erythematosus, 54, 99, 105, 108-111, 114-115, 121, 122, 135 against thymic hormones, 45 without lymphoid hyperplasia, 99 Y-linked, 38, 87-89, 91, 93-94, 97 B B cell defects absence of mature cells, 92-94 atrophy, 101 and autoimmunity, 111, 113 blocked complement receptors on, 141 decreased numbers of cells, 47 diminished response to type I antigens, 86 functional lesions, 85-86 hyperactivity, 107, 111, 118- 119 in Ia expression, 63 in immunoglobulin expression, 63, 86, 107 inability to proliferate in presence of LPS, 63 increased function in mutants, 45, 126 ionizing radiation and, 145 Ly- 1 + population, 66, 86, 107 Lyb-3 expression, 86 in Lyb-5 subpopulation, 86, 92, 107 maturation factors, 98 polyclonal activation, 66 production of pathogenic IgG anti-DNA, 109 proliferative response impairment, 63, 66, 78 resistance to induction of immunologic tolerance, 107 in response to T-cell replacing factors, 98 sIg+ population, 86 thymic proliferation, 119 activation of, 9, 163 differentiation of, 3, 4, 6-7, 9, 116 function of, 3, 4, 8, 9, 218 immunoglobin secretion, 3, 5, 7 interaction with T cells, 3, 7, 9, 92, 98, 109, 112, 116, 119 maturation of, 91 proliferation of, 3, 4, 6-7, 9 see also Antibodies Babesia rodhaini, 143 Read the entire page →
From page 235... ... , 109-110 ConA, impaired response to, 47, 84, 91, 127, 141, 145, 220 Congenic mouse strains A.SW, 117 BXSB-xid, 94 B10.D2/oSnJ, 55 C.B-Igh-Ib (CB17) , 77-80 C57BL/KsJ.B6-H-2b, 73 NOD.NON-H-2, 100, 101 NZB.CB/N-xid, 106-107 SJL/J-lpr, 117 Congenic strains, defined, 16, 220 Conjunctivitis, 128 Corynebacterium parvam, 119, 127- 128 Coxsackievirus B4, 14 Cryptococcus neoformans 137 Cytolysis, 4 Cytomegalovirus, 143 D Demyelinating disease, susceptibility to, 117, 120, 162, 163 Dendritic cells follicular, antigen retention by, 126 function of, 3, 8, 221 Thy- 1 + epidermal cells, lack of, 77 see also Langerhans' cells Read the entire page →
From page 236... ... 39 Guinea pigs, monoclonal antibodies reacting to cell surface antigens in, 213-215 H Halothane, 12 Hamster mutants, 1, 14; see also Table 2-1, p. 39 Hamsters immunoglobulin subclasses, 5 monoclonal antibodies reacting to cell surface antigens in, 213-215 Haptenated-Ficoll, failure to respond to, 85 Hemobartonella mur~s, 12 Henoch-Schonlein purpura, 135, 222 Heparin, 10 Read the entire page →
From page 237... ... , 13 Humoral immunity, deficiencies in, 66, 144 Husbandry practices bedding, 153 caging or housing system, 112, 120, 148, 149, 151 cesarean derivation, 128 conventional environment, 14 defined-flora, 14, 71, 219, 221 disease surveillance, 154 environmental conditions, 14, 59, 151-153 filter hoods, 128, 149 general considerations, 14- 15, 69, 148-149, 151 germ-free isolation, 14, 67, 71, 75, 102, 127, 128, 133, 150-151, 222 HEPA-filtered laminar-air-flow systems, 149-150, 151, 223 and immunosuppression, 12, 50, 55 infection control in commercial stock, 153-154 insulin treatment for diabetic rodents, 203, 131 laminar flow, 133 pathogen-free environment, 1, 14, 43, 51, 71, 76, 79, 96, 108, 112, 121, 125, 127-129, 133, 139, 149, 219, 227, 229 prevention of fighting among rodents, 120, 154 retirement and replacement of breeders, 62 single-user, SPF, barrier-protected room, 79, 128 strict isolation, 14 temperature conditions, 59, 151 - 152 transfer of animals between facilities, 153-154 see also Diet Hybrid mouse strains (see also Table 2-1, p. Read the entire page →
From page 238... ... . 1mmunosuppresslon 1 ~ hormones and, 10 immunodeficiency and, 10- 11 and infectious agents, 12-14 and lymphomagenesis, 57 and noninfectious agents, 11- 12 in nursing mice, 50 see also Adaptive immune system/ mechanisms Immunodeficiencies/immunosuppression and activation of latent infections, 143-144 by alkylating agents, 142 biological inducers, 145- 146 chemically induced, 140-143 classification of disorders, 11 defined, 2, 10, 224 drug-induced, 12, 13; see also Antibiotics; and specific drugs environmental causes, 10- 11 genetic causes, 10-11; see also Guinea pig mutants; Hamster mutants; Mouse mutants; Mutations; Rat mutants by glucocorticoids, 142- 143 by heavy metals, 11, 141 by infectious agents, 12- 14, 143- 144; see also specific agents by ionizing radiation, 144-145 and lymphoid malignancies, model for, 79 by noninfectious agents, 11- 12, 140-143, 144-147 nutrition and, 144 by phenols, 141-142 stress and, 11- 12, 50, 146 by thymectomy, 146- 147 by ultraviolet radiation, 145 X-linked, 85-87, 90-94 Immunoglobulins absence of, 84-85 B cell production of, 3, 5, 7 decreased levels of, 47, 70-71, 77, 85-86, 90, 94, 117, 138, 141 defect in expression of, 63, 86 defect in isotype switching, 136 function of, 5-6, 224 IgA, 50, 61, 70, 84-85, 88, 115, 126 IgD, 86, 126 IgE, 117 IgG, 5, 10, 47, 50, 59, 61, 63, 66, 70, 80, 88, 90, 91, 94, 106, 111, 113, 115, 118, 126, 134, 135, 136, 138, 141, 145, 146 IgM, 47, 49, 61, 66, 70, 86, 90, 91, 94, 105-107, 110-111, 113, 115, 135, 136, 145 increased levels of, 58, 61, 66, 91, 94, 105, 107, 110-111; see also Hyperimmunoglobulinemia kidney deposits of, 50, 66, 94, 115 Al, 118 and reticulum cell sarcomas, 118 rheumatoid factors, 61 species differences in, 5 structure of, 4-6 suppression of, 12 Immunologic specificity, see Adaptive immune system/mechanisms Inbred mouse strains (see also Table 2-1, p. Read the entire page →
From page 239... ... 39) BBZ/Wor, 133 BN, 161 DA, 126 F344, 126, 163 LEW, 126, 161, 163 PVG, 126 WAG, 126 see also Reproduction Infectious agents clinically silent, 12- 13 depression of oncogenic virus genes, 13 effects of glucocorticoids on susceptibility to, 143 genetic mechanisms in resistance or susceptibility to, 161- 164 immunosuppression by, 12- 14 synergistic effects between, 13 X-linked resistance to, 163 see also specific agents Inflammatory response, 4, 9, 10, 221 Influenza A, 161 Insulin, 10, 14, 17, 43-45, 72, 100, 103, 130-134 239 Insulinopenia, 72 Insulitis, 100-101, 104, 131, 133 Interferons activation of NK cells with, 42, 119 defined, 224 ~y-, 9, 98, 111, 224 poly(A-U) Read the entire page →
From page 240... ... , 46, 50, 66, 72, 74, 77, 78, 110, 126, 131, 132, 225 diet-induced, 11 drug-induced, 12 in IL-2 production 54 lymph node, 46, 77, 126, 138 peripheral blood, 50, 227 self-directed cytotoxic lymphocytes, 61 splenic, 52, 68, 77, 84 thymic, 84, 126 Lymphocytes differentiation antigens, see Cell surface antigens follicular aggregates of, 105 peripheral blood, 50, 227 radiosensitivity, 145 receptors, 10, 60 repopulation of, 79 thymic-derived, 54 see also specific lymphocytes Lymphocytic choriomeningitis virus (LCMV) , 12, 13, 14, 147 Lymphokine-activated killer cells, independence from NK cells, 93 Lymphokines depressed production of, 45 functions of, 7, 225 see also Interleukin Lymphomagenesis, 57, 71 Lymphomas autoimmune disease and, 106, 110, 114 defined, 225 follicle center cell, 102 genes affecting, 117 immunoblastic sarcoma, 138 nonthymic, 121 reticulum cell sarcomas, 71, 117- 119, 228 thymic, 57, 78 Lymphopoietic cells, abnormality in. Read the entire page →
From page 241... ... , 7-8, 9, 70, 118, 130, 142, 163, 220, 223 defect in expression of, 63, 105 and diabetes, 100-101, 130-131 expression of, 8 genetic locus, 114, 117, 130- 131 role of, 7, 226 structure of, 7-8 T-cell receptor allele associated with responsiveness to, 118 Mammary tumor viruses, 13 Mast cells antibody interaction with, 3, 10 cytoplasmic marker for, 42 defects in, 41, 83 function of, 8, 10, 225-226 Mating systems, see Reproduction Measles, 161 Melanocytes, 81, 83, 226 Melanoma, 73, 92 Membrane attack complex, 55, 226 Mice monoclonal antibodies reacting to cell surface antigens in, 213-215 strains, see Congenic mouse strains; Hybrid mouse strains; Inbred mouse strains; Outbred mouse strains stress in, 12 transgenic, 101 see also Mouse mutants Microphthalmia, 37, 51-52, 67-69, 73-77 Microwave irradiation, 145 Mink, Aleutian trait, 41 Minute virus of mice (MVM) , 12 Mixed lymphocyte reactions (MLRs) Read the entire page →
From page 242... ... , 13, 57, 71, 78, 92, 115, 117, 119-120, 121, 222, 226 Murine pinworm (Syphacia obvelata) , 14 Mutations advantages and disadvantages of, 15 allelic, 1, 36, 37, 39-40, 42, 43, 54-58, 62-71, 82, 125-126 antigen-selected somatic, 110 codominant/semidominant, 15, 67, 82, 220, 229 definition, 15, 226 lethal, 51-52, 84, 124-125, 156, 158, 159 maintenance of, 15-16; see also Reproduction modification of, 16 multiple, 1, 16, 44-45, 90-94 nomenclature for, 15, 17, 34 provirus integration into normal allele, 56 radiation-induced, 40, 42, 67 sex-linked, 85 single point, 1, 36-90 spontaneous, 15, 40, 43, 47, 51, 52, 58, 59, 64, 69, 72, 73, 75, 77, 80, 84, 123, 124, 128 see also Hamster mutants; Mouse mutants; Rat mutants Mycobacterium bovis, resistance/ susceptibility mutants, 36, 37, 39-40, 127 Mycobacterium lepraemurium, resistance/ susceptibility mutants, 36, 39-40 Mycoplasma pulmonis, 128, 163 Myocardial infarction, 60, 110 N Natural killer (NK) Read the entire page →
From page 243... ... , 1, 14, 147 tl (toothless) , 39, 123, 124, 128- 129 Rats adjuvant arthritis in, 14 immunoglobulins, 5 linkage map, 32-33 monoclonal antibodies reacting to cell surface antigens in, 213-215 stress in, 12 see also Inbred rats; Rat mutants Raucher virus, 13 Renal disease, 50, 54, 61, 66, 91, 94, 99, 108, 110, 112, 114, 121 Reovirus 3, 12, 14 Reproduction backcross linkage analysis, 63 backcrosses, 59, 64, 86-88, 99, 100-101, 126, 156-158, 160, 218 balanced stock, 156- 157, 219 brother x sister mating, 52. Read the entire page →
From page 244... ... , impaired response to, 95 Stress, and immunosuppression, 11 - 12, 142, 146 Submandibular gland, leukocyte infiltrates of, 104 Systemic lupus erythematosus, 54, 99, 105, 108-111, 114-115, 121, 122, 135, 229 T T cell defects absence of mature cells, 92-94 antibody response against erythrocytes, 107 Read the entire page →
From page 245... ... , 7, 10 Ts, 9, 230 see also Lymphocytes Taenia teaniaformis, 164 Thrombocytes, elevation of, 47 Thymectomy, 146-147 Thymic defects absence of Ia+ cells, 70 athymia, 93, 138, 148 atrophy, 49-50, 57, 110, 142, 144 B-cell influx, 119 epithelial dysgenesis, 70 hyperplasia, 105, 110, 114 involution, 45, 51, 65, 105* 140 lymphomas, 57, 78, 79 reduced cellularity, 84 small organ, 58, 65, 77 Thymulin, 50, 105, 230 Thymus function of, 230 model of functional relationships with spleen and bone marrow, 93 see also Thymic defects Thyroid defects calcitonin-secreting cells, 74, 76 follicular cells, 41, 51 Hashimoto-like thyroiditis, 132, 133, 222 thyroiditis, 95 Thyrotropic hormone-producing cells, deficiencies in, 49 Thyroxine, 10 Tonsils, 8 Transmissible ileal hyperplasia, 139 Trichinella spiralis, 83, 147, 164 Trichuris muris, 164 Tris, 140 Tumor growth and metastasis anesthetic agents and, 12 models for, 69-71, 92 NK cell activity and, 92 Tumors and tumor cell lines B16F10, 92 CEM, 92 contaminants in, 12 human, 92 immunosuppression by, 146 impaired cytolysis of, 42 K562, 92 LOX, 92 murine, 92 ovarian granulosa cell tumors, 92 reticulum cell neoplasms, 99 Read the entire page →
From page 246... ... 246 INDEX suppression of, 13 YAC-1, 92 Tyzzer's disease, 128 U Ultraviolet radiation, and immunosuppression, 145, 230-231 V Variable-region-coding elements, aberrant deletions of, 78 Vascular disease, 97, 110 Vasculitis, 135, 114, 222 W Wasting disease, 71, 84-85 Water, hyperchlorinated acidified, 11, 152-153 X Xenografts, 79, 231 Read the entire page →

From page 233...

... Index A Adaptive immune system/mechanisms, 2-10, 224 Adenosine deaminase, 85, 217; see also Severe combined immunodeficiency p-Adrenergic substances, 10 Allergic contact dermatitis, 81, 220 Alopecia, 57, 116; see also Mouse mutants nu; Rat mutants, rnu Amyloidosis, 116, 119, 122, 218 Antigens Anemia autoimmune hemolytic, 88, 97, 105- 106, 112, 220 defined, 218 macrocytic, 82-83 in osteopetrotic mutations, 51, 68 Antibiotics, and immunosuppression, 12 Antibodies anti-class II MHC, 132 anti-DNP, 135, 218 antihistone, 115 antinuclear, 50, 54, 61, 70, 88, 94, 99, 109, 114, 115, 122, 218 B cell production of, 3 deficiency in LPS-induced adjuvant response to, 63 enhanced production of, 142 function of, 3-4, 10 233 genetic mechanisms in diversification of, 6-7 T-cell-dependent responses, 140-141, 142 T-cell independent responses, 140- 141 thymocyte-binding, 88 viral inhibition of, 13 see also Autoantibodies; Immunoglobulins Antibody-dependent cytotoxic cells, 10, 217 Brucella, 50 defective responses to, 115, 116, 135, 136 designations, 2 IaW39, 86 I-E surface, 101 monoclonal antibodies reacting to, 213-215 resistance to tolerance induction by, 119 retroviral gp70, 108, 112 T-cell dependent, 116, 135- 137 T-cell independent, 116, 230 thymus-dependent, 85, 115, 230 thymus-independent, 85, 230 thyroid-stimulating hormone receptor (TSH) , 14 see also Major histocompatibility complex antigens

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From page 234...

... , 106 reduced levels of, 91 thymus-binding, 54, 227 Autoimmunity/autoimmuine disease acceleration of, 87-89, 91, 93-94, 97, 112 autoantibodies characteristic of, 14 autoimmune polyendocrine disease, 14 B cell depletion and, 94 correction of, 107-108 defined, 2, 218 early-onset lymphoid hyperplasia with, 52 environmental factors in, 13-14 estrogen therapy and, 99 experimental autoimmune encephalomyelitis B cells (EAE) , 95, 117-118, 120, 221 genes controlling susceptibility to, 105, 161 hemolytic anemia, 105 induced by MHV, 162 Ly-1+ B cell population and, 66 modification of natural history, 86-87 orchiectomy and, 88 progressive auto~mmune lymphoproliferative disease, 94 spontaneous, 13-14, 70, 101, 105 systemic lupus erythematosus, 54, 99, 105, 108-111, 114-115, 121, 122, 135 against thymic hormones, 45 without lymphoid hyperplasia, 99 Y-linked, 38, 87-89, 91, 93-94, 97 B B cell defects absence of mature cells, 92-94 atrophy, 101 and autoimmunity, 111, 113 blocked complement receptors on, 141 decreased numbers of cells, 47 diminished response to type I antigens, 86 functional lesions, 85-86 hyperactivity, 107, 111, 118- 119 in Ia expression, 63 in immunoglobulin expression, 63, 86, 107 inability to proliferate in presence of LPS, 63 increased function in mutants, 45, 126 ionizing radiation and, 145 Ly- 1 + population, 66, 86, 107 Lyb-3 expression, 86 in Lyb-5 subpopulation, 86, 92, 107 maturation factors, 98 polyclonal activation, 66 production of pathogenic IgG anti-DNA, 109 proliferative response impairment, 63, 66, 78 resistance to induction of immunologic tolerance, 107 in response to T-cell replacing factors, 98 sIg+ population, 86 thymic proliferation, 119 activation of, 9, 163 differentiation of, 3, 4, 6-7, 9, 116 function of, 3, 4, 8, 9, 218 immunoglobin secretion, 3, 5, 7 interaction with T cells, 3, 7, 9, 92, 98, 109, 112, 116, 119 maturation of, 91 proliferation of, 3, 4, 6-7, 9 see also Antibodies Babesia rodhaini, 143

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From page 235...

... , 109-110 ConA, impaired response to, 47, 84, 91, 127, 141, 145, 220 Congenic mouse strains A.SW, 117 BXSB-xid, 94 B10.D2/oSnJ, 55 C.B-Igh-Ib (CB17) , 77-80 C57BL/KsJ.B6-H-2b, 73 NOD.NON-H-2, 100, 101 NZB.CB/N-xid, 106-107 SJL/J-lpr, 117 Congenic strains, defined, 16, 220 Conjunctivitis, 128 Corynebacterium parvam, 119, 127- 128 Coxsackievirus B4, 14 Cryptococcus neoformans 137 Cytolysis, 4 Cytomegalovirus, 143 D Demyelinating disease, susceptibility to, 117, 120, 162, 163 Dendritic cells follicular, antigen retention by, 126 function of, 3, 8, 221 Thy- 1 + epidermal cells, lack of, 77 see also Langerhans' cells

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From page 236...

... 39 Guinea pigs, monoclonal antibodies reacting to cell surface antigens in, 213-215 H Halothane, 12 Hamster mutants, 1, 14; see also Table 2-1, p. 39 Hamsters immunoglobulin subclasses, 5 monoclonal antibodies reacting to cell surface antigens in, 213-215 Haptenated-Ficoll, failure to respond to, 85 Hemobartonella mur~s, 12 Henoch-Schonlein purpura, 135, 222 Heparin, 10

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From page 237...

... , 13 Humoral immunity, deficiencies in, 66, 144 Husbandry practices bedding, 153 caging or housing system, 112, 120, 148, 149, 151 cesarean derivation, 128 conventional environment, 14 defined-flora, 14, 71, 219, 221 disease surveillance, 154 environmental conditions, 14, 59, 151-153 filter hoods, 128, 149 general considerations, 14- 15, 69, 148-149, 151 germ-free isolation, 14, 67, 71, 75, 102, 127, 128, 133, 150-151, 222 HEPA-filtered laminar-air-flow systems, 149-150, 151, 223 and immunosuppression, 12, 50, 55 infection control in commercial stock, 153-154 insulin treatment for diabetic rodents, 203, 131 laminar flow, 133 pathogen-free environment, 1, 14, 43, 51, 71, 76, 79, 96, 108, 112, 121, 125, 127-129, 133, 139, 149, 219, 227, 229 prevention of fighting among rodents, 120, 154 retirement and replacement of breeders, 62 single-user, SPF, barrier-protected room, 79, 128 strict isolation, 14 temperature conditions, 59, 151 - 152 transfer of animals between facilities, 153-154 see also Diet Hybrid mouse strains (see also Table 2-1, p.

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From page 238...

... . 1mmunosuppresslon 1 ~ hormones and, 10 immunodeficiency and, 10- 11 and infectious agents, 12-14 and lymphomagenesis, 57 and noninfectious agents, 11- 12 in nursing mice, 50 see also Adaptive immune system/ mechanisms Immunodeficiencies/immunosuppression and activation of latent infections, 143-144 by alkylating agents, 142 biological inducers, 145- 146 chemically induced, 140-143 classification of disorders, 11 defined, 2, 10, 224 drug-induced, 12, 13; see also Antibiotics; and specific drugs environmental causes, 10- 11 genetic causes, 10-11; see also Guinea pig mutants; Hamster mutants; Mouse mutants; Mutations; Rat mutants by glucocorticoids, 142- 143 by heavy metals, 11, 141 by infectious agents, 12- 14, 143- 144; see also specific agents by ionizing radiation, 144-145 and lymphoid malignancies, model for, 79 by noninfectious agents, 11- 12, 140-143, 144-147 nutrition and, 144 by phenols, 141-142 stress and, 11- 12, 50, 146 by thymectomy, 146- 147 by ultraviolet radiation, 145 X-linked, 85-87, 90-94 Immunoglobulins absence of, 84-85 B cell production of, 3, 5, 7 decreased levels of, 47, 70-71, 77, 85-86, 90, 94, 117, 138, 141 defect in expression of, 63, 86 defect in isotype switching, 136 function of, 5-6, 224 IgA, 50, 61, 70, 84-85, 88, 115, 126 IgD, 86, 126 IgE, 117 IgG, 5, 10, 47, 50, 59, 61, 63, 66, 70, 80, 88, 90, 91, 94, 106, 111, 113, 115, 118, 126, 134, 135, 136, 138, 141, 145, 146 IgM, 47, 49, 61, 66, 70, 86, 90, 91, 94, 105-107, 110-111, 113, 115, 135, 136, 145 increased levels of, 58, 61, 66, 91, 94, 105, 107, 110-111; see also Hyperimmunoglobulinemia kidney deposits of, 50, 66, 94, 115 Al, 118 and reticulum cell sarcomas, 118 rheumatoid factors, 61 species differences in, 5 structure of, 4-6 suppression of, 12 Immunologic specificity, see Adaptive immune system/mechanisms Inbred mouse strains (see also Table 2-1, p.

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From page 239...

... 39) BBZ/Wor, 133 BN, 161 DA, 126 F344, 126, 163 LEW, 126, 161, 163 PVG, 126 WAG, 126 see also Reproduction Infectious agents clinically silent, 12- 13 depression of oncogenic virus genes, 13 effects of glucocorticoids on susceptibility to, 143 genetic mechanisms in resistance or susceptibility to, 161- 164 immunosuppression by, 12- 14 synergistic effects between, 13 X-linked resistance to, 163 see also specific agents Inflammatory response, 4, 9, 10, 221 Influenza A, 161 Insulin, 10, 14, 17, 43-45, 72, 100, 103, 130-134 239 Insulinopenia, 72 Insulitis, 100-101, 104, 131, 133 Interferons activation of NK cells with, 42, 119 defined, 224 ~y-, 9, 98, 111, 224 poly(A-U)

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From page 240...

... , 46, 50, 66, 72, 74, 77, 78, 110, 126, 131, 132, 225 diet-induced, 11 drug-induced, 12 in IL-2 production 54 lymph node, 46, 77, 126, 138 peripheral blood, 50, 227 self-directed cytotoxic lymphocytes, 61 splenic, 52, 68, 77, 84 thymic, 84, 126 Lymphocytes differentiation antigens, see Cell surface antigens follicular aggregates of, 105 peripheral blood, 50, 227 radiosensitivity, 145 receptors, 10, 60 repopulation of, 79 thymic-derived, 54 see also specific lymphocytes Lymphocytic choriomeningitis virus (LCMV) , 12, 13, 14, 147 Lymphokine-activated killer cells, independence from NK cells, 93 Lymphokines depressed production of, 45 functions of, 7, 225 see also Interleukin Lymphomagenesis, 57, 71 Lymphomas autoimmune disease and, 106, 110, 114 defined, 225 follicle center cell, 102 genes affecting, 117 immunoblastic sarcoma, 138 nonthymic, 121 reticulum cell sarcomas, 71, 117- 119, 228 thymic, 57, 78 Lymphopoietic cells, abnormality in.

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From page 241...

... , 7-8, 9, 70, 118, 130, 142, 163, 220, 223 defect in expression of, 63, 105 and diabetes, 100-101, 130-131 expression of, 8 genetic locus, 114, 117, 130- 131 role of, 7, 226 structure of, 7-8 T-cell receptor allele associated with responsiveness to, 118 Mammary tumor viruses, 13 Mast cells antibody interaction with, 3, 10 cytoplasmic marker for, 42 defects in, 41, 83 function of, 8, 10, 225-226 Mating systems, see Reproduction Measles, 161 Melanocytes, 81, 83, 226 Melanoma, 73, 92 Membrane attack complex, 55, 226 Mice monoclonal antibodies reacting to cell surface antigens in, 213-215 strains, see Congenic mouse strains; Hybrid mouse strains; Inbred mouse strains; Outbred mouse strains stress in, 12 transgenic, 101 see also Mouse mutants Microphthalmia, 37, 51-52, 67-69, 73-77 Microwave irradiation, 145 Mink, Aleutian trait, 41 Minute virus of mice (MVM) , 12 Mixed lymphocyte reactions (MLRs)

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From page 242...

... , 13, 57, 71, 78, 92, 115, 117, 119-120, 121, 222, 226 Murine pinworm (Syphacia obvelata) , 14 Mutations advantages and disadvantages of, 15 allelic, 1, 36, 37, 39-40, 42, 43, 54-58, 62-71, 82, 125-126 antigen-selected somatic, 110 codominant/semidominant, 15, 67, 82, 220, 229 definition, 15, 226 lethal, 51-52, 84, 124-125, 156, 158, 159 maintenance of, 15-16; see also Reproduction modification of, 16 multiple, 1, 16, 44-45, 90-94 nomenclature for, 15, 17, 34 provirus integration into normal allele, 56 radiation-induced, 40, 42, 67 sex-linked, 85 single point, 1, 36-90 spontaneous, 15, 40, 43, 47, 51, 52, 58, 59, 64, 69, 72, 73, 75, 77, 80, 84, 123, 124, 128 see also Hamster mutants; Mouse mutants; Rat mutants Mycobacterium bovis, resistance/ susceptibility mutants, 36, 37, 39-40, 127 Mycobacterium lepraemurium, resistance/ susceptibility mutants, 36, 39-40 Mycoplasma pulmonis, 128, 163 Myocardial infarction, 60, 110 N Natural killer (NK)

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From page 243...

... , 1, 14, 147 tl (toothless) , 39, 123, 124, 128- 129 Rats adjuvant arthritis in, 14 immunoglobulins, 5 linkage map, 32-33 monoclonal antibodies reacting to cell surface antigens in, 213-215 stress in, 12 see also Inbred rats; Rat mutants Raucher virus, 13 Renal disease, 50, 54, 61, 66, 91, 94, 99, 108, 110, 112, 114, 121 Reovirus 3, 12, 14 Reproduction backcross linkage analysis, 63 backcrosses, 59, 64, 86-88, 99, 100-101, 126, 156-158, 160, 218 balanced stock, 156- 157, 219 brother x sister mating, 52.

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From page 244...

... , impaired response to, 95 Stress, and immunosuppression, 11 - 12, 142, 146 Submandibular gland, leukocyte infiltrates of, 104 Systemic lupus erythematosus, 54, 99, 105, 108-111, 114-115, 121, 122, 135, 229 T T cell defects absence of mature cells, 92-94 antibody response against erythrocytes, 107

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From page 245...

... , 7, 10 Ts, 9, 230 see also Lymphocytes Taenia teaniaformis, 164 Thrombocytes, elevation of, 47 Thymectomy, 146-147 Thymic defects absence of Ia+ cells, 70 athymia, 93, 138, 148 atrophy, 49-50, 57, 110, 142, 144 B-cell influx, 119 epithelial dysgenesis, 70 hyperplasia, 105, 110, 114 involution, 45, 51, 65, 105* 140 lymphomas, 57, 78, 79 reduced cellularity, 84 small organ, 58, 65, 77 Thymulin, 50, 105, 230 Thymus function of, 230 model of functional relationships with spleen and bone marrow, 93 see also Thymic defects Thyroid defects calcitonin-secreting cells, 74, 76 follicular cells, 41, 51 Hashimoto-like thyroiditis, 132, 133, 222 thyroiditis, 95 Thyrotropic hormone-producing cells, deficiencies in, 49 Thyroxine, 10 Tonsils, 8 Transmissible ileal hyperplasia, 139 Trichinella spiralis, 83, 147, 164 Trichuris muris, 164 Tris, 140 Tumor growth and metastasis anesthetic agents and, 12 models for, 69-71, 92 NK cell activity and, 92 Tumors and tumor cell lines B16F10, 92 CEM, 92 contaminants in, 12 human, 92 immunosuppression by, 146 impaired cytolysis of, 42 K562, 92 LOX, 92 murine, 92 ovarian granulosa cell tumors, 92 reticulum cell neoplasms, 99

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From page 246...

... 246 INDEX suppression of, 13 YAC-1, 92 Tyzzer's disease, 128 U Ultraviolet radiation, and immunosuppression, 145, 230-231 V Variable-region-coding elements, aberrant deletions of, 78 Vascular disease, 97, 110 Vasculitis, 135, 114, 222 W Wasting disease, 71, 84-85 Water, hyperchlorinated acidified, 11, 152-153 X Xenografts, 79, 231

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INDEX Pages 233-246

INDEX
Pages 233-246