Immunization Safety Review SV40 Contamination of Polio Vaccine and Cancer (2003) / Chapter Skim
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Appendix A: Committee Recommendations and Conclusions from Previous Reports
Appendix A: Committee Recommendations and Conclusions from Previous Reports
Pages 85-95
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From page 85... ...
The committee concludes that further research on the possible occurrence of ASD in a small number of children subsequent to MMR vaccination is warranted, and it has identified targeted research opportunities that could lead to firmer understanding of the relationship. Recommendations Public Health Response The committee recommends that the relationship between the MMR vaccine and autistic spectrum disorders receive continued attention.
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From page 86... ...
The committee recommends conducting further clinical and epidemiological studies of sufficient rigor to identify risk factors and biological markers of ASD in order to better understand genetic or environmental causes. Communica~dons The committee recommends that government agencies and professional organizations, CDC and the Food and Drug Administration (FDA)
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From page 87... ...
The committee recommends that full consideration be given by appropriate professional societies and government agencies to removing thimerosal from vaccines administered to infants, children, or pregnant women in the United States. The committee recommends that appropriate professional societies and government agencies review their policies about the non-vaccine biological and pharmaceutical products that contain thimerosal and are used by infants, children, and pregnant women in the United States.
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From page 88... ...
Public Health and Biomedical Research The committee recommends a diverse public health and biomedical research portfolio. Epidemiological Research The committee recommends case-control studies examining the potential link between neurodevelopmental disorders and thimerosal-containing vaccines.
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The committee recommends research in appropriate animal models on the neurodevelopmental effects of ethylmercury.
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From page 90... ...
The committee concludes that the epidemiological evidence is inadequate to accept or reject a causal relationship between multiple immunizations and increased risk of allergic disease, particularly asthma. Biological Mechanisms Conclusions Autoimmune Disease In the absence of experimental or human evidence regarding molecular mimicry or mercury-induced modification of any vaccine component to create an antigenic epitope capable of cross-reaction with self epitopes as a mechanism by which multiple immunizations under the U.S.
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From page 91... ...
infant immunization schedule could possibly influence an individual's risk for heterologous infections. Significance Assessment The committee concludes that concern about multiple immunizations has been, and could continue to be, of societal significance in terms of parental worries, potential health burdens, and future challenges for immunization policymaking.
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From page 92... ...
Furthermore, the committee recommends that disease registries and research programs for autoimmune and allergic disorders routinely collect immunization histories as part of their study protocol. Basic Science and Clinical Research The committee recommends continued research on the development of the human infant immune system.
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From page 93... ...
The committee recommends exploring surrogates for allergy and autoimmunity in existing cohort studies of variations in the vaccine schedule. Communication The committee recommends that an appropriate panel of multidisciplinary experts be convened by the Department of Health and Human Services.
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Biological Mechanisms Conclusions The committee concludes that there is weak evidence for biological mechanisms by which hepatitis B vaccination could possibly influence an individual's
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PUBLIC HEALTH RESPONSE RECOMMENDATIONS Policy Review The committee does not recommend a policy review of the hepatitis B vaccine by any of the national and federal vaccine advisory bodies on the basis of concerns about demyelinating neurological disorders. The committee recommends continued surveillance of hepatitis B disease and increased surveillance of secondary diseases such as cirrhosis and hepatocellular carcinoma.
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