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7. Reproductive and Developmental Effects
Pages 393-446

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From page 393... ... and AL amyloidosis. Biologic Plausibility An association has been reported between AL amyloidosis and TCDD exposure in a single study in mice, but the TCDD exposure was relatively intense and may or may not be relevant to Vietnam veterans. Read the entire page →
From page 394... ... . Adjustments for potential confounders, such as body-mass index and alcohol consumption, did not change the overall results. Read the entire page →
From page 395... ... Because animal data and the sparse human data support the possible biologic plausibility of an association between TCDD exposure and endometriosis, that possible association should continue to be investigated. Increased Risk of Disease Among Vietnam Veterans There are insufficient data on endometTiosis in Vietnam veterans to draw a specific conclusion as to whether Vietnam veterans are at increased risk for this disorder. Read the entire page →
From page 396... ... Secretion of T4 and T3 is under the control of thyroid-stimulating hormone (TSH) , which is secreted by the anterior pituitary gland. Read the entire page →
From page 397... ... PREPUBLICATION COPY- UNCORRECTED PROOF were significantly greater in the high-exposure than the low-exposure group, and the same was true at ~ ~ weeks, when, in addition, TSH concentrations were also significantly higher. When only infants who were breastfed for the Al ~ ~ weeks were considered, only the ratio of total T4 to TBG remained significantly different between the two groups. Read the entire page →
From page 398... ... The possibility of neurodevelopmental effects secondary to mild hypothyroidism induced in early pregnancy by TCDD or dioxin-like compounds cannot be excluded (Vuisma 2000~. Conclusions Strength of Evidence from Epidemiologic Studies There is inadequate or insufficient evidence of an association between exposure to the chemicals of interest (2,4-D, 2,4,5-T or its contaminant TCDD, picloram, or cacodylic acid) Read the entire page →
From page 399... ... Similarly, the AFHS demonstrated biologic changes In TSH without accompanying effect on the health ofthe Ranch Hands. SUMMARY On the basis of the occupational, environmental, and veterans studies reviewed, the committee reached one of four conclusions about the strength of the evidence regarding association between exposure to the chemicals of interest (2,4-D, 2,4,5-T or its contaminant TCDD, picloram, or cacodylic acid) Read the entire page →
From page 400... ... Typically, at least one high-quality study indicates a positive association, but the results of other studies might be inconsistent. In Update 1996, Update 1998, and Update 2000, the committee found limited or suggestive evidence of an association between exposure to at least one of the chemicals of interest (2,4-D, 2,4,5-T or its contaminant TCDD, picloram, or cacodylic acid) Read the entire page →
From page 401... ... The committees responsible for LAO, Update 1996, Update 1998, and Update 2000 concluded that none of the health outcomes discussed in this chapter had limited or suggestive evidence of no association with the exposures of interest (2,4-D, 2,4,5-T or its contaminant TCDD, picloram, or cacodylic acid) Read the entire page →
From page 402... ... Cacodylic acid was reported to induce renal lesions in rats. Other studies provide evidence that 2,4-D binds covalently to hepatic proteins and lipids; the molecular basis of the interaction and its biologic consequences are unknown. Read the entire page →
From page 403... ... American Journal of Industrial Medicine 16:119-125. Bastomsky CH. Read the entire page →
From page 404... ... A report ofthe 1996 retrospective cohort study of Australian Vietnam veterans. Canberra: DeparDnent of Veterans' Affairs. Read the entire page →
From page 405... ... 1994. Veterans and Agent Orange: Health Effects of Herbicides Used in Vietnam. Read the entire page →
From page 406... ... 1996. The Australian Vietnam Veterans Health Study: II. Read the entire page →
From page 407... ... American Journal of Epidemiology 136~7~:855-862. Steenland K, Piacitelli L, Deddens J Read the entire page →
From page 408... ... , on the basis of its review of the epidemiologic evidence and consideration of the quality of available exposure information, especially Tom studies of Vietnam veterans, this committee concludes that continuation of epidemiologic studies of veterans could yield valuable information. That is true especially because diseases of aging could emerge as the population grows older, and as a new exposure-reconstruction mode} is developed and validatecI. Read the entire page →
From page 409... ... The AFHS is one of the few primary sources of information on the health of Vietnam veterans known to be exposed to Agent Orange and other herbicides. The study is coming to its scheduled end as the cohorts are reaching the age at which several health outcomes of interest may be expected to manifest, such as cancers and diseases related to aging. Read the entire page →
From page 410... ... The data could be used in epidemiologic studies, such as studies of ground troops, to examine possible associations between health effects and exposure to the herbicide mixtures used in Vietnam. Combining research into the health effects of the herbicides in Vietnam veterans and potential information from this database, might provide better information on the health effects of the chemicals of interest. Read the entire page →
From page 411... ... 2002. Veterans and Agent Orange: Herbicide/Dioxin Exposure and Acute Myelogenous Leukemia in the Children of Vietnam Veterans. Read the entire page →
From page 412... ... Husband's death and Agent Orange Jennie LeFevre 3:45 P.M. Veterans' health problems, heart (lisease, cliabetes, peripheral neuropathy, soft knots covering body, chioracne 4~2 Read the entire page →
From page 413... ... Glioblastomas in Vietnam Veterans Danna Hughes, President, Vietnam Veterans Wives (Presented by warren Driggs) Read the entire page →
From page 414... ... It is used for the purposes of classifying morbidity and mortality information for statistical purposes, indexing hospital records by disease and operations, reporting diagnosis by physicians, data storage and retrieval, reporting national morbidity and mortality data, and reporting and compiling health care `data. Many of the studies reviewed by the committee use ICD-9 classifications. Read the entire page →
From page 415... ... 193. 164.0 194.0-194.9 Lymphomas Hodgkin's disease Non-lIodgkin's lymphomas 201.0-201.9 200.0-200.8, 202.0-202.2, 202.8-202.9 Multiple myeloma 203.0, 203.2-203.8 Leukemias Lymphocytic Acute lymphocytic Chronic lymphocytic Other lymphocytic 415 204.0 204.1 204.2-204.9 Read the entire page →
From page 416... ... PREPUBLICATION COPY- UNCORRECTED PROOF Cancer Site ICD-9 codes Granulocytic (myeloid) Acute myeloid Chronic myeloid Other myeloid Monocytic Acute monocytic Chronic monocytic Other monocytic Other Other acute Other chronic Aleukemic, subleukemic and NOS 205.0 205.1 205.2-205.9 206.0 206.1 206.2-206.9 207.0, 208.0 207.1, 208.1 202.4, 203.1, 207.2, 207.8, 208.2-208.9 Ill-defined and unspecified sites 159.1, 195.0~195.8, 196.~196.9, 199.~199.1, 202.3, 202.5-202.6 ABBREVIATION: NOS=not otherwise specified. Read the entire page →
From page 417... ... Dr. Hertz-Picciotto also served as chair of the Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides (Third Biennial Update) Read the entire page →
From page 418... ... He also served as a member of the Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides (Third Biennial Update) Read the entire page →
From page 419... ... His research examines the epidemiology of cardiovascular disease and diabetes and the impact of socioeconomic status and race on health. He also served as a member of the Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides (Third Biennial Update) Read the entire page →
From page 420... ... She has also been involved with the TOM committees that produced Organ Procurement and Transplantation; Clearing the Air: Asthma and Indoor Air Exposures; Veterans and Agent Orange: Herbicide/Dioxin Exposure and Type 2 Diabetes; Veterans and Agent Orange: Update 2000; md Veterans and Agent Orange: Herbicide/Dioxin Exposure and Acute Myelogenous Leukemia in the Children of Vietnam Veterans. Read the entire page →
From page 421... ... PREPUBLICATION COPY- UNCORRECTED PROOF of health-system change on the public-health infrastructure, access to care for vulnerable populations, managed care, and the health-care workforce. Read the entire page →
From page 422... ... PREPUBLICATION COPY- UNCORRECTED PROOF of health-system change on the public-health infrastructure, access to care for vulnerable populations, managed care, and the health-care workforce. Read the entire page →

From page 393...

... and AL amyloidosis. Biologic Plausibility An association has been reported between AL amyloidosis and TCDD exposure in a single study in mice, but the TCDD exposure was relatively intense and may or may not be relevant to Vietnam veterans.

7. Reproductive and Developmental Effects Pages 393-446

7. Reproductive and Developmental Effects
Pages 393-446