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Pages 584-600

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From page 584...
... _ _ . A Acetone hairy cell leukemia and, 326 multiple myeloma and, 306 rectal cancer and, 203 Acute human exposures to carbamates, 52-53 to DEET, 67-68 delayed effects, 44 46 immediate effects, 43~4 to lindane, 64-65 organophosphorous compounds, 43~6 to pyrethrins and pyrethroids, 59~0 Acute leukemia, 13~135, 308 and benzene, 320-321 and mixtures of organic solvents, 321322 and solvent exposure, 319-322 Acute lymphocytic leukemia, 336 Acute nonlymphocytic leukemia, 336 AD.
From page 585...
... 20 and mixtures of organic solvents, 257259 and solvent exposure, 24~259 and tetrachloroethylene and dry-cleaning solvents, 255 and toluene, 256-257 and trichloroethylene, 254 and xylene, 257 Blood glucose concentrations, of pyrethrins and pyrethroids, 62 Bone cancer, 110 and benzene, 225 and insecticide exposure, 110-111 and mixtures of organic solvents, 225 and solvent exposure, 224-225 and trichloroethylene, 225 Brain and central nervous system (CNS) tumors, 121 and benzene, 28O and chloroform, 281 and insecticide exposure, 121-123 and methylene chloride, 279 and mixtures of organic solvents, 281 and phenol, 28O and solvent exposure, 272-282 and tetrachloroethylene and dry-cleaning solvents, 278-279 and toluene, 28O and trichloroethylene, 277-278 and xylene, 28O Breast cancer, 114 and benzene, 235 and insecticide exposure, 114-117 and methylene chloride, 236 and mixtures of organic solvents, 236 and solvent exposure, 230-236 and tetrachloroethylene and dry-cleaning solvents, 235 and trichloroethylene, 234 Bronchospasm, from organophosphorous compounds, 49 2-Butoxyethanol glycol, chemical structure of, 91
From page 586...
... ~ ~ brain and CNS tumors, 121-123 childhood cancer, 139-146 female reproductive cancers, ~ I~117 gastrointestinal tract cancers, 102-105 hepatobiliary cancers, 105-107 Hodgkin's disease, 130-131 lung cancer, 107-l 10 multiple myeloma, ~32-l34 non-Hodgkin's lymphoma, 123-130 oral, nasal, and laryngeal cancers, 101102 skin cancer, ~ 12-l 14 soft tissue sarcoma, ~ ~ I-] 12 urologic cancers, ~ 17-120 Cancers and exposure to organic solvents, 156-349 adult leukemia, 308, 313-319 bone cancer, 22~225 brain and CNS cancers, 272-282 breast cancer, 230-236 childhood cancers, 331-338 female reproductive cancers, 237-241 gastrointestinal tract tumors, ~ 8~207 hepatobiliary cancers, 207-214 Hodgkin's disease, 297, 299-301 lung cancer, 21~224 lymphatic and hematopoetic cancers, 2g2 multiple myleloma, 301-307 myelodysplastic syndromes, 32~331 non-Hodgkin's lymphoma, 283, 288-296 GULF WAR AND HEALTH oral, nasal, and laryngeal cancer, ~ 79IS4 skin cancer, 22~230 soft tissue sarcoma, 225 urologic cancers, 241-272 Carbamate interactions with other agents, 5~57 and AhR action, 56 cimetidine, 56 inhibitor SKF525A effects, 56 malathion coadministration, 56 phenobarbital, 56 Carbamates, I, 10, 51-57 acute human exposure, 52-53 carbary1, I, 10 carcinogenicity, 54 chemical structure of, 5 chemistry of, 5 ~ developmental effects, 5~55 experimental data on, 53-55 genetic polymorphisms and susceptibility, 52 genotoxicity, 54 immune function changes, 55 immunosuppression, 55 interactions with other agents, 56-57 lysozyme activity changes, 55 mechanism of action, 52 methomy1, I, 10 mutagenicity, 54 neurotoxic effects, 53-54 proxpur, I, 10 reproductive effects, 5~55 serum complement-fixing activity changes, 55 toxicokinetics, 51-52 Carbary1, I, 10 chemical structure of, 5 ~ sperm and semen parameters and, 455 Carboxylesterase, interactions with organophosphorous compounds, 50 Carcinogenicity of carbamates, 54 of lindane, 65 of organophosphorous compounds, 4748
From page 587...
... tumors Cervical cancer, ~ 14 and methylene chloride, 239 and mixtures of organic solvents, 239 and solvent exposure, 237-239 and tetrachioroethylene and dry-cleaning solvents, 239 and trichioroethylene, 239 Chance, assessing the effect of, 26 Chemical interactions multiple exposures and, 13-14 research recommendations from Gulf War and Health, Volume I, 564 See also Interactions with other agents Chemical structures azamethiphos, 41 benzene, 85 2-butoxyethanol, 91 n-buty! acetate, 93 carbamates, 51 carbaryT, 5 ~ chiorpyrifos, 41 cyclohexanol, 90 DEET, 67 diazinon, 41 dichIorvos, 41 n,n-diethyI-3-methy~benzamide, 67 diethylene glycol, 91 diethylene glyco]
From page 588...
... See Brain and central nervous system (CNS) tumors Cognitive impairment, organophosphorousinduced delayed, 46 Colon or colorectal cancer, ~ 02 end benzene, 198-199 and insecticide exposure, 103, 105 and methylene chloride, 199 and mixtures of organic solvents, 200 and phenol, 199 and solvent exposure, 195-200 and tetrachIoroethylene and dry-cleaning solvents, 198 end toluene, 199 and trichIoroethylene, 197-198 an~xylene, 199 Color discrimination, 439~40 Color vision testing, 581 Concentration, symptoms related to, 38 387 Confounding, 28-30 Congenital malformations, 469 heart, 471~72, 475 and insecticide exposure, 470~73 and maternal exposure, 473, 477 multiple and other malformations, 472 neural-tube defects and other CNS anomalies, 4707, 474 oral clefts, 475~76 other types of, 476 and paternal exposure, 473, 477 and solvent exposure, 474 477 Connective-tissue disorder, undifferentiated, 520 Cross-sectional studies, definition, 21-22 Cyclohexanol, chemical structure of, 90 GULF WAR AND HEALTH D Danish Study, of Gulf War veterans, 547548 Databases bibliographic, 566 factual, 566 Davis, Miriam, 533-561 DEET.
From page 589...
... , 575-576 End-stage renal disease, and solvents, 508 Endometrial cancer, and methylene chloride, 241 Environmental particles and pollutants, I, 10 diesel heater fumes, I, 10 hydrogen sulfide, I, 10 oil-fire byproducts, i, 10 send microparticles, I, lO Epidemiologic study designs, 21-24 case-control studies, 22-24 cohort studies, 22 cross-sectional studies, 21-22 ecologic studies, 21 experimental studies, 24 Escherichia coil, pathogenic, 2, 589 and insecticide exposure, 105 and methylene chloride, ~ 90 and mixtures of organic solvents, ~91 end phenol, 191 and solvent exposure, l8~191 and tetrachioroethylene and dry-cleaning solvents, 190 end toluene, 190 end trichIoroethylene, 189 end xylene, 190 Esters, 93-94 chemical structure of various, 93 iso-buty! acetate, 93 1-methoxy-2-propano!
From page 590...
... butyl ether, 91 ethylene glycol, 91 hexylene glycol, 91 propylene glycol, 91 GULF WAR AND HEALTH toxicology of, 90-92 Gulf War and Health, Volume I, 2, ~ i, 563566 conclusions, 563-564 research recommendations from, 56 565 Gulf War health issues, 13-15 complexities in addressing, 13 lack ofexposureinformation, 14 literature on, 17-21, 565-568 multiple exposures and chemical interactions, 13-14 unexplained symptoms, 14 the war experience, 1~15 Gulf War veterans studies, 536-550 Canadian Study, 544 Danish Study, 547-548 Female Air Force Veterans Study, 548 Genetic Susceptibility Study, 549-550 "Iowa Study," 538-541 major studies of Gulf War veterans' symptoms and syndromes, 538 Massachusetts and New Orleans Veterans Study, 548 Naval Reservists Study, 548-549 Neurologic Dysfunction Study, 548-549 Oregon and Washington Veterans Study, 543-544 Pennsylvania and Hawaii Veterans Study, 548 University of London Study, 54~546 University of Manchester Study, 54 547 VA Study, 541-543 H Hairy cell leukemia, 135, 308 and acetone, 326 and benzene, 325 and mixtures of organic solvents, 326 and solvent exposure, 325-326 and trichloroethylene, 326 Halogenated hydrocarbons, 85-89 chloroform, 88-89 methylene chloride, 87-88 tetrachloroethylene, 86
From page 591...
... INDEX toxicology of, 85-89 trichIoroethylene, 8~87 Hearing Toss, 440~41 Hepatic effects, 499-502 cirrhosis, 501 liver function, 500 and solvent exposure, 499-502 Hepatic steatosis, 500-502 Hepatobiliary cancers, See also Liver cancer, 105 and benzene, 213 and insecticide exposure, 105-107 and methylene chloride, 212 and mixtures of organic solvents, 213214 and phenol, 213 and solvent exposure, 207-214 and tetrachIoroethylene and dry-clean~ng solvents, 212 and toluene, 213 and trichioroethylene, 21 I-212 Hepatotoxic effects, of pyrethrins and pyrethroids, 62 Hexylene glycol, chemical structure of, 91 Hodgkin's disease, 130 and benzene, 299-300 and insecticide exposure, 130~131 and mixtures of organic solvents, 300 301 and phenol, 300 and solvent exposure, 297-301 and tetrachioroethylene and dry-cleaning solvents, 300 and toluene, 300 and trichIoroethylene, 299 and xylene, 300 Hospitalization studies, of Gulf War veterans, 551-552 Hydrazine, I, 10 Hydrocarbons aromatic, 8~85 chronic renal failure and, 508 glomeruTonephritis and, 508 halogenated, 85-89 Hydrogen sulfide, I, 10 591 Hypersensitivities, from organophosphorous compounds, 49 Illnesses in Gulf War veterans epidemiologic studies of veterans' symptoms and general health status, 53 550 limitations of past and current studies, 555-556 overview of, 533-562 population-based studies, 537-550 registry programs, 53~536 Immune function changes, from carbamates, 55 Immunosuppression, of carbamates, 55 Immunotoxic effects of lindane, 66 from organophosphorous compounds, 49 of pyrethrins and pyrethroids, 61-62 Infertility, 453~55, 458~61 Information bias, 27-28 Inhibitor SKF525A effects, interactions with carbamates, 56 Insecticide exposure and specific cancers, 98-155 adultleukemia end, 13~139 aplastic anemia and, 486 bone cancer and, ~ ~ 0-] ~ ~ brain and CNS tumors and, 121-123 breast cancer and, ~ ~ ~1 ~ 7 cancers and, 98-155 childhood cancer end, 139-146 childhood leukemia and, 145-146 congenital malformations and, 473 female reproductive cancers and, 11 117 gastrointestinal tract cancers and, 102105 hepatobiliary cancers and, 105-107 Hodgkin's disease and, 130-131 lung cancer and, 107-110 multiple myeloma and, 132-134 non-Hodgkin's lymphoma and, 123-130 oral, nasal, and laryngeal cancers and, 101-102
From page 592...
... 592 pancreatic cancer and, 105 skin cancer and, ~ 12-114 soft tissue sarcoma and, ~ ~ I-112 urologic cancers and, ~ 17-120 Insecticide literature, and cancer, 99-100 Insecticide toxicology, 39-~1 carbamates, 51-57 chemistry of, 41 DEET, 66~9 lindane, 63-66 organophosphorous compounds, 39-50 pyrethrins and pyrethroids, 57~3 Insecticides and neurologic diseases, 41 I421 Alzheimer's disease, 420~21 amyotrophic lateral sclerosis, 418~19 Parkinson's disease, 412~] Insecticides and peripheral neuropathy,35 370 Gulf War veterans and, 356-362 OP insecticides and, 362-370 Insecticides used in the Gulf War, 12-13, 571 Interactions with other agents of carbamates, 56-57 of DEET, 69 of organophosphorous compounds, 50 of pyrethrins and pyrethroids, 62~3 "Iowa Study," 538-541 exposure-symptom relationships, 540 results of, 541 symptom clustering, 540 Irritant contact dermatitis and other skin disorders, 5 ~ 0-5 ~ I, 5 ~ 3-5 14 Iso-buty} acetate, chemical structure of, 93 Isopropanol, chemical structure of, 90 Isopropyl alcohol kidney cancer and, 270 multiple myeloma and, 306 K Ketones chemical structure of, 94 toxicology of, 94 Kidney cancer, ~ ~ 7-l GULF WAR AND HEALTH and benzene, 270 and insecticide exposure, 118-120 and isopropyl alcohol, 270 and mixtures of organic solvents, 270272 and solvent exposure, 259-272 and tetrachloroethylene and dry-cleaning solvents, 268-269 and toluene, 270 and trichloroethylene, 267-268 and xylene, 270 L Laryngeal cancers, 101 and insecticide exposure, 101-102 and solvent exposure, 180-183 Latency period, 33 Leishmaniasis, 2, 11 Leukemia, 13~135,307-308 acute,308,319-322 acute lymphocytic, 336 acute nonlymphocytic, 336 adult, 307-308, 313-319 childhood, 140-142, 145-146,332, 335336 chronic, 308, 322-323 hairy cell, 325-326 lymphatic, 323-325 Lindane, 1, 10, 63~6 acute human exposures, 64-65 carcinogenicity, 65 chemical structure of, 63, 64 chemistry of, 63 developmental effects, 66 experimental data on, 65-66 immunotoxic effects, 66 mechanism of action, 64 mutagenicity, 65 neurotoxic effects, 65 reproductive effects, 66 toxicokinetics, 64 Live vaccines, 2, 11 Liver cancer, See also Hepatobiliary cancers, 105 and insecticide exposure, 106-107 and solvent exposure, 207-214
From page 593...
... acetate, chemical structure of, 93 Methylene chloride, 87-88 brain and CNS tumors and, 279 breast cancer and, 236 cervical cancer and, 239 colon cancer and, 199 endometrial cancer and, 241 esophageal cancer and, ~ 90 hepatobiliary cancers and, 212 lung cancer and, 221 melanoma skin cancers and, 228 multiple myeloma and, 306 ovarian cancer and, 240 pancreatic cancer and, 206 prostate cancer and, 246 rectal cancer and, 203 stomach cancer and, ~ 94 uterine cancer and, 241 Microwave radiation, 2, ~ 0 Mixtures of organic solvents acute leukemia and, 321-322 adult leukemia and, 317-319 bladder cancer and, 257-259 bone cancer and, 225 brain and CNS tumors and, 2 breast cancer and, 236 cervical cancer and, 239 chronic leukemia and, 323 colon cancer and, 200 esophageal cancer and, 191 hairy cell leukemia and, 326 hepatobiliary cancers and, 213-214 Hodgkin's disease and, 300-301 kidney cancer and, 270-272 lung cancer and, 223-224 lymphatic leukemia and, 324 melanoma skin cancers and, 229 multiple myeloma and, 306-307
From page 594...
... , 51 516 Multiple exposures, and chemical interactions, 13-14 Multiple myeloma, 132 and acetone, 306 and benzene, 305 and insecticide exposure, 132-134 and isopropyl alcohol, 306 and methylene chloride, 306 and mixtures of organic solvents, 30 307 and solvent exposure, 301-307 and tetrachIoroethylene and dry-cleaning solvents, 306 and toluene, 306 and trichloroethylene,30~305 Multiple sclerosis, 429~34 Mustard agents, 1, 10 Mutagenicity from carbamates, 54 from lindane, 65 from organophosphorous compounds, 48 from pyrethrins and pyrethroids, 61 Myelodysplastic syndromes, 326 and benzene, 330 and mixtures of organic solvents, 330 331 and solvent exposure, 327-33 N Nasal cancers, 101 and insecticide exposure, 101-102 and solvent exposure, 179-180 GULF WAR AND HEALTH Naval Reservists Study, of Gulf War veterans, 548-549 NB. See Neurobehavioral effects Nerve agents and precursor compounds, I, 10 satin, 1, 10 tabun, 1, 10 Neural-tube defects (NTDs)
From page 595...
... See Neural-tube defects o Oil-fire byproducts, 1, 10 Olfactory function, 441 595 Online databases, 565-568 OP. See Organophosphorous compounds OP insecticides and neurobehavioral effects, 388~03 with a history of past OP poisoning, 389393 without a history of past OP poisoning, 393~03 OP insecticides and peripheral neuropathy, 362-370 OP poisoning neurobehavioral effects with past history of, 390 neurobehavioral effects without past history of, 39~397 Oral cancers, 101 and insecticide exposure, 101-102 and solvent exposure, 179-181 Oral clefts, 475~76 Oregon and Washington Veterans Study, of Gulf War veterans, 543-544 Organic solvents.
From page 596...
... See Pyridostigmine bromide PD. See Parkinson's disease Pennsylvania and Hawaii Veterans Study, 548 Peripheral neuropathy electromyograms, 575-576 insecticides and, 356-370 neurologic examination of, 574-576 and organophosphorous insecticide exposures, 365-367 solvents and, 371-377 vibrotactile threshold, 576 Permethrins, I, 10 GULF WAR AND HEALTH chemical structure of, 58 interactions with DEET, 69 Pesticides carbamate, I, 10 chIorinated-hydrocarbons, 1, 10 organophosphorous, 1, 10 Petroleum distillates, toxicology of, 94-95 Phenobarbital, interactions with carbamates, 56 Phenol adult leukemia and,317 brain and CNS tumors and, 280 colon cancer and, 199 esophageal cancer and, 191 hepatobiliary cancers and, 213 Hodgkin's disease and, 300 lung cancer and, 222 melanoma skin cancers and, 229 non-Hodgkin's Tymphoma and, 293 nonmelanoma skin cancers and, 229 pancreatic cancer and, 206 rectal cancer and, 203 stomach cancer and, 194 d-Phenothrin, chemical structure of, 58 Piperony]
From page 597...
... , i, 10 research recommendations from Gulf War and Health, Volume i, 564 R Radiation sources, 2, ~ 0 clepleted uranium, 2, 10 microwave radiation, 2, 10 radiofrequency radiation, 2, ~ 0 597 uranium, 2, ~ 0 Radiofrequency radiation, 2, 10 Reactive airways dysfunction syndrome, 498 Rectal or colorectal cancer, 102 and acetone, 203 and benzene, 202 and insecticides exposure, ~ 03, ~ 05 and methylene chloride, 203 and mixtures of organic solvents, 203 and phenol, 203 and solvent exposure, 200-203 and tetrachIoroethylene and dry-cleaning solvents, 202 and toluene, 203 and trichloroethylene, 202 and xylene, 203 Red fuming nitric acid, 1, 10 Registry programs for Gulf War veterans, 534-536 demographic characteristics of US Gulf War troops, 534 most frequent symptoms and diagnoses of participants in VA registry, 535 Renal effects, 50~508 Reproductive effects, 450~83 of carbamates, 5~55 congenital malformations, 469~77 of DEET, 69 of lindane, 66 of organophosphorous compounds, 4849 preconception, 450~61 during pregnancy, 461~69 of pyrethrins and pyrethroids, 61 Research recommendations from Gulf War and Health, Volume 1, 564 biological, chemical, and psychological interactions, 564 depleted uranium, 564 pyridostigmine bromide, 564 sarin, 564 vaccines, 564 Respiratory effects, 494~98 Rheumatic diseases, systemic, 519-520 Rheumatoid arthritis, 520
From page 598...
... 73 Alzheimer's disease and, 435~37 bladder cancer and, 248-251 brain and CNS cancers and, 272-274 breast cancer and, 230-232 cancers from, 156-349 childhood cancer and,331-334 gastrointestinal tract tumors and, I85187 Hodgkin's disease and, 297-298 kidney cancer and, 260-264 leukemia and, 308-312 liver cancer and, 207-208 lung cancer and, 215 melanoma skin cancers and, 226-227 multiple myeloma and,301-302 multiple sclerosis and, 431~32 GULF WAR AND HEALTH myelodysplastic syndromes and, 327-329 neurobehavioral effects and, 405~06 non-Hodgkin's lymphoma and, 283-287 oral, nasal, and laryngeal cancer and, ~ SO peripheral neuropathy and, 372-374 prostate cancer and, 241-242 Solvent interactions, 84 Solvent toxicity, 83-84 Solvent toxicokinetics, 83 Solvent toxicology, 82-97 alcohols, 89-90 aromatic hydrocarbons, 8~85 esters, 93-94 glyco} ethers, 92-93 glycols, 90-92 halogenated hydrocarbons, 85-89 ketones, 94 petroleum distillates, 9~95 Solvents, I, 10 amyotrophic lateral sclerosis and, 425427 aplastic anemia and, 489~91 and color discrimination, 439~40 end-stage renal disease and, 508 genetic polymorphisms and susceptibility, 84 giomerulonephritis and, 508 and hearing loss, 440~41 information about, 83-84 and neurobehavioral effects, 403~11 and olfactory function, 441 and peripheral neuropathy, 371-377 and sensory effects, 439~41 sent to the Gulf War, 13, 571 time-to-pregnancy effects and, 461 See also Mixtures of organic solvents, individual solvents Solvents and neurologic diseases, 421~39 ATzheimer's disease, 434~39 amyotrophic lateral sclerosis, 424~29 multiple sclerosis, 429~34 Parkinson's disease, 421~24 Sperm parameters, 451~53, 455~58 and carbaryT, 455 Stomach cancer, 102 and benzene, 193
From page 599...
... See Cimetidine Tert-buty} acetate, chemical structure of, 93 Testicular cancer, 117 and insecticide exposure, 118-120 Tetrachioroethylene and dry-cleaning solvents, 86 adult leukemia and, 317 bladder cancer and, 255 brain and CNS tumors and, 278-279 breast cancer and, 235 cervical cancer and, 239 colon cancer and, 198 esophageal cancer and, 190 hepatobiliary cancers anal, 212 Hodgkin's disease and, 300 kidney cancer and, 268-269 Jung cancer and, 220 melanoma skin cancers and, 22X multiple myeloma and, 306 non-Hodgkin's lymphoma and, 293 nonmelanoma skin cancers and, 229 ovarian cancer and, 240 pancreatic cancer and, 205 prostate cancer and, 245 rectal cancer and, 202 stomach cancer and, 193 uterine cancer and, 241 Thyroid weight, of pyrethrins and pyrethroids, 62 Time-to-pregnancy effects and benzene, 461 and ethylene glyco! ethers, 461 and insecticide exposure, 455 and solvents, 461 Toluene adult leukemia and,317 bladder cancer and, 25~257 brain and CNS tumors and, 280 chemical structure of, 85 colon cancer and, 199 esophageal cancer and, 190 hepatobiliary cancers and, 213 Hodgkin's disease and, 300 kidney cancer and, 270 lung cancer and, 222 multiple myeloma and, 306 non-Hodgkin's lymphoma and, 292-293 pancreatic cancer and, 206 prostate cancer and, 245 rectal cancer and, 203 stomach cancer and, 194 Toxicity and carcinogenicity, 100-101 and determination of carcinogenicity, 157-159 Toxicokinetics of carbamates, 51-52 of DEET, 67 of lindane, 64
From page 600...
... 600 of organophosphorous compounds, 40 41 of pyrethrins and pyrethroids, 58 of solvents, 83 Toxicology of insecticides, 39-81 of solvents, 82-97 Toxoid vaccines, 2, ~ 1 Trichloroethylene, 8~87 adult leukemia and,316 bladder cancer and, 254 bone cancer and, 225 brain and CNS tumors and, 277-278 breast cancer and, 234 cervical cancer and, 239 colon cancer and, ~ 97-198 esophageal cancer and, 189 hairy cell leukemia and, 326 hepatobiliary cancers and, 21 I-212 Hodgkin's disease and, 299 kidney cancer and, 267-268 lung cancer and, 219-220 melanoma skin cancers and, 228 multiple myeloma and, 30~305 non-Hodgkin's lymphoma and, 290-291 nonmelanoma skin cancers and, 229 ovarian cancer and, 240 pancreatic cancer and, 205 prostate cancer and, 24~245 rectal cancer and, 202 stomach cancer and, ~ 93 uterine cancer and, 241 U Undifferentiated connective-tissue disorder, Xylene 520 University of London Study, of Gulf War veterans, 544-546 University of Manchester Study, of Gulf War veterans, 546-547 Unmeasured confounding in cohort studies, 28-29 Uranium? 2, ~ 0 depleted, 2, 10 Urologic cancers, ~ ~ 7-118 and insecticide exposure, ~ ~ 8-120 GULF WAR AND HEALTH and solvent exposure, 241-272 Uterine cancer, ~ 14-1 ~ 5 and methylene chloride, 241 and mixtures of organic solvents, 241 and solvent exposure, 240-241 and tetrachloroethylene and dry-cleaning solvents, 241 and trichIoroethylene, 24 V VA registry, 535 VA Study, of Gulf War veterans, 541-543 Vaccines live, "attenuated," and toxoid, 2, ~ ~ research recommendations from Gulf War and Health, Volume 1, 564 Validity of findings, 25-33 assessing the effect of bias, 26 27 assessing the effect of chance, 26 confounding, 28-30 exposure assessment, 30-32 health outcome assessment, 32-33 information bias, 27-28 latency period and fatality rate, 33 selection bias, 27 Vibrotactile threshold, 576 Visual deficits, organophosphorous-induced delayed, 46 Volatile organic compounds, 1, 10 W War experience, 1~15 X bladder cancer and, 257 brain and CNS tumors and, 280 colon cancer and, 199 esophageal cancer and, 190 Hodgkin's disease and, 300 kidney cancer and, 270 non-Hodgkin's lymphoma and, 292-293 pancreatic cancer and, 206 prostate cancer and, 245 rectal cancer and, 203 stomach cancer and, 194


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