Biographical Memoirs Volume 82 (2003) / Chapter Skim
Currently Skimming:
Donald C. Shreffler
Donald C. Shreffler
Pages 286-305
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From page 287... ...
Specific MHC molecules appear to predispose the incliviclual carrying them to clevelop certain autoimmune diseases. Structure/function studies on the MHC genes, their products, en c!
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From page 288... ...
spenc! the clay with church activities, family gatherings, en cl for Don, playing with his cousins, especially cousin Norman.
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From page 289... ...
thesis in Ray Owen's laboratory. He obtained a National Science Foundation precloctoral fellowship for his thesis research on mouse plasma proteins.
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From page 290... ...
Our interest in the early days of bone marrow transplantation, immunological tolerance, and the cellular antigens of mice was enriched by extensive working visits from such leaders as Elizabeth Russell of Bar Harbor on the genetics of blood cell formation in mice, David Nanney and his student Eduardo Orias, and ~ean-Marie Dubert, Eleanor Brandt, and John Loeffer on immunogenetics and mating in Tetyrahymena. Bill Stone, on leave from Wisconsin, looked for blood factors deriving from gene interaction, for human blood typing reagents from immune sera produced in cattle, and for effects of irradiation on the state of immunological suppression.
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From page 291... ...
His studies on the mouse Ss protein revealecl that the Ss gene mappecl within the H2 gene complex in the seventeenth chromosome of the mouse. He establishecl a close relationship with George Snell at the Jackson Laboratories in Bar Harbor, Maine.
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From page 292... ...
. lane also remembers Don as being a very social person, joining the graduate students for beer at the local pubs en cl at impromptu parties at society meetings, and enjoying the hospitality at their home.
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was not correct. Don took me to an H2 meeting in Bar Harbor organized by George Snell.
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From page 294... ...
This resultecl in a major collaboration between Hugh McDevitt, Donalcl Shreffler, {an Klein, lack Stimpfling, en cl George Snell to map the location of the Ir gene. Studies using the various recombinant strains showocl that the Ir gene mapped inside the H2 gene complex, probably between H2K en c!
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From page 295... ...
Hugh remembers Don as "a gentle, thoughtful, en cl rigorous investigator who was extremely generous with his many MHC recombinant mouse strains, as well as with acivice." Hugh rememberecl that "cluring our Ir gene mapping studies Don was extraorclinariTy helpful. In discussions both here at Stanforc!
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From page 296... ...
preclominantly on antigenpresenting cells and not T cells. Jeff Frelinger fondly remembers many parties at Don's house, especially the annual Christmas parties.
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From page 297... ...
In a major collaboration between our lab en cl Stan Nathenson's laboratory at Albert Einstein University, Susan Cullen showocl that Ia antigens consisted! of two chains of 33,000 en c!
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Don spent several weeks each summer teaching a mammalian genetics course in Bar Harbor, Maine, where he took his whole family. The main activity there was mackerel fishing.
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of several "superstars" in immunogenetics, such as Hugh McDevitt en cl Stan Nathenson. This was too exciting for Don to turn clown.
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Karp, thoroughly characterized the Ss en cl SIp proteins biochemically. Keith Parker remembers Don as one of those icleal mentors who was always available for discussion, listener!
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The pioneers of the H2 fielcl Peter Grover, George Snell, Bernard Amos, Jack Stimpfling, Don Shreffler, en c! Jan Klein were all honorecl at this happy occasion.
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To Don's wife, Dorothy, and his sons, David and Doug, for their input. I also appreciate contributions from Ray Owen, lane Schultz, Hugh McDevitt, Jeff Frelinger, Keith Parker, and David Karp.
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Genetic and antigenic studies and partial purification of a human serum lipoprotein carrying the Lp antigenic determinant.
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Membrane molecules determined by the H-2-associated immune response region: Isolation and some properties.
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Roos. Structural characterization of the murine fourth component of complement and sex-limited protein and their precursors: Evidence for two loci in the S region of the H-2 complex.
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