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Appendix A: Power Calculations
Pages 17-18

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From page 17...
... Illustrative calculations were made for non-Hodgkin's lymphoma (NHL) .1 The sample sizes were estimated on the basis of a 1-tailed chisquare test with alpha = 0.05 and beta = 0.80, an unequal sample size for the exposed and comparison groups (1:4 ratio)
From page 18...
... 18 EXPOSURE OF VETERANS TO AGENT ORANGE AND OTHER HERBICIDES RR Number Number Sample exposed comparison size needed 1.25 23,310 93,240 116,550 1.50 6,356 25,422 31,778 1.75 3,057 12,227 15,283 2.00 1,849 7,395 9,243 2.50 936 3,742 4,677 3.00 590 2,359 2,948 4.00 319 1,273 1,591 5.00 211 842 1,052 All else equal, diseases that are more common than NHL among individuals in the same age bracket as US veterans of Vietnam would require smaller sample sizes to detect the same RR; less common diseases would require larger sample sizes. Using a larger percentage of exposed individuals would also decrease the sample size needed to detect the same RR.


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