Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research (2003) / Chapter Skim
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Introduction
Introduction
Pages 1-4
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Identify common research themes in contemporary neuroscience and behavioral research based on input from neuroscience and behavioral researchers most familiar with current standards of practice and veterinarian specialists in laboratory animal medicine.
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Further, recognizing that every potential research situation cannot be anticipated, there are few regulations or guidelines governing laboratory animal care and use that do not end with the caveat "unless a deviation is justified for scientific reasons and approved by the IACUC." To provide such flexibility in the regulations and guidelines requires the application of professional judgment when applying these regulations and guidelines to each research situation. Often the decisions that must be made are not simple, and reaching effective solutions requires the collective judgment and cooperation of the principal investigator, veterinarian, and IACUC.
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Individuals that are well acquainted with the Animal Welfare Act, the Guide, and PHS Policy, may wish to immediately direct their attention to the second section, Chapters 4-9, "Applications to Common Research Themes in Neuroscience and Behavioral Research." This section is based on the six common research themes that the committee identified: survival studies, prolonged nonsurvival studies, studies of neural injury and disease, perinatal studies, agents and treatments, and behavioral studies. This second section discusses current best practices and how they apply to research situations unique to neuroscience and behavioral research.
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Those situations include intended and unintended pain and/or distress, multiple major survival surgeries and modified surgical settings, implantation of devices, and the stresses associated with behavioral paradigms. Recognizing that an experimental protocol can involve elements that are addressed in more than one chapter of this publication, the authoring committee has provided extensive cross-referencing to guide the reader.
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