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Science, Medicine, and Animals (2004) / Chapter Skim
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Understanding Epilepsy
Pages 13-16

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From page 13...
... Michael Rogawski at the National Institutes of Health (NIH) , scientists are seeking to understand the mechanisms of abnormal electrical activity in the brain at the cellular and molecular level and to develop drugs that will con trol seizures without side effects.
From page 14...
... Cultured rat neurons lack the complex connections between brain regions that are present in whole brains or brain slices but are still useful in the early stages of research. After a chemical compound's activity has been thor oughly studied in a cell model, the researchers use 1/2-mm-thick brain slices from young adult rats.
From page 15...
... It is absolutely essential to study the action of potential new drugs in a complete nervous system." Rogawski's research takes advantage of the fact that epilepsy is not only a human disease. Seizures occur frequently in many purebred dogs and in baboons, as well as other species.
From page 16...
... Scientists use these mice to study a wide variety of immune diseases, even though these mice are perfectly normal. By studying green mice, scientists have studied how immune cells from the mother are passed to infants through breastfeeding, how different immune cells interact, and how fetal immune cells migrate out of the womb and into the mother's organs, which may cause some autoimmune diseases.

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