Biographical Memoirs Volume 83 (2003) / Chapter Skim
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George Davis Snell
George Davis Snell
Pages 252-269
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From page 253... ...
Most of his life was spent at Bar Harbor, Maine, where he workocl in the Jackson Laboratory. George was prouc!
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From page 254... ...
It was not until I studied genetics with Professor John Gerould at Dartmouth College that I became sufficiently involved in any branch of science to think of making it a career. Even then, it was not until I graduated that I finally decided, with the encouragement of Professor Gerould, to enter a graduate school.
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From page 255... ...
He worked within a tradition of classical Mendelian genetics that flourished through most of his lifetime en cl still connects tociay with molecular genetics. The Jackson Laboratory with its magnificent mouse facility suited George perfectly, en cl he proviclecl exactly the foresight en cl drive that it neeclecI.
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From page 256... ...
The stock from his prize chives is still hanclecl clown among the Jackson geneticists, en cl his vegetable patch can still be seen on AtIan tic Avenue. {an Klein cites the mice that bear the label "/Sn" as his living monument.
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From page 257... ...
Muller hacl cliscoverecl that racliation incluces mutations in Drosophila. In a series of papers between 1933 en cl 1946 George proved that same effect couIcl be obtained in the mouse, as a representative species of mammal.
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From page 258... ...
for military service, as well as that of his competitor Peter Hertwig, who hacl continual to publish papers on mouse genetics in Berlin until ~ 942! George's pioneering work on transiocation in mammals pointed in three future directions.
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From page 259... ...
his clebut in tumor transplantation, a fielcl of research that he came to dominate en cl in which he macle his great discovery of the major histocompatibility complex. ClouUman had Tong been working with Little at the Jackson Laboratory.
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From page 260... ...
Gorer raisecl rabbit antisera to reel bloocl cells of mice, which upon absorption clistinguishec! two antigens present in different strains.
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From page 261... ...
Meanwhile, the genetics of the MHC, the work for which George received the Nobel Prize, steamed ahead on an expanding scale. The work depended on two simple but ingenious procedures.
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From page 262... ...
" was coined to describe this series of closely linkocl genes. In parallel Hugh McDevitt cliscoverecl that genes of the MHC hacl the unexpected function of controlling the level of the immune response.
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From page 263... ...
Simpson write, "Snell and his collaborators' masterful exploitation of the fortuitous linkage of H3 to agouti en cl other visually detectable linker! loci .
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From page 264... ...
This is an extensive survey of human evolution from a genetic en cl anthropological standpoint, which argues that the origins of ethical behavior can be tracecl to particular periods en cl structures of human society. The book is hare!
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From page 265... ...
I AM GRATEFUL TO Jan Mein, Elizabeth Simpson, Derry Roopenian, Will Silvers, and Henry Metzger for help in preparing this memoir. The library of Jackson Laboratory has an extensive Snell archive, a useful Snell reprint collection, and a full Snell bibliography.
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From page 266... ...
14:926-28. 1932 The role of male parthenogenesis in the evolution of the social hymenoptera.
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From page 267... ...
Strong and weak histocompatibility gene differences in mice and their role in the rejection of homografts tumors and skin.
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From page 268... ...
Genetic control of the immune response. Mapping of the Ir-1 locus.
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