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Biographical Memoirs Volume 83 (2003) / Chapter Skim
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Jeffries Wyman
Pages 362-377

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From page 363...
... , American Academy of Arts en cl Sciences, en cl the Italian Accaclemia clef Lincei, but the important thing was that he was sought out by biochemists around the worIcl for acivice en cl collaboration. {effries Wyman was born June ill, 1901, in West Newton, Massachusetts.
From page 364...
... 2 After graduation {effries spent 1923-24 in Harvard Gracluate School taking acivancecl courses in physics en cl chemistry. In June 1924 Jeffries Wyman en c!
From page 365...
... He showocl that the clielectric increment was 23 for oc-amino acids, 71 for clipepticles, en cl Il5 for tripepticles. Ecisall2 writes that Jeffries's ciata on polar liquicis stimulate cl Lars Onsager to pro cluce the first acloquate the ory of the clielectric properties of polar liquicis.
From page 366...
... They gave a general treatment of the fact that the effect of oxygenation in increasing the acid dissociation constant of hemoglobin in the alkaline loop implies a reciprocal effect involving a decrease of oxygen affinity with hydrogen ion concentration in the same region. These effects are reversed in the acid loop.
From page 367...
... that the interaction is clue to entropy effects, because the heat effect is the same for each stage of the four-step oxygenation process, whereas the free energy change clue to the heme interactions certainly cliffers markocIly from one step to the next. They suggested that configuration effects involving entropy changes conic!
From page 368...
... While in Rome, {effries clevelopecl fully the theory of linkocl functions en cl reciprocal effects in his lancimark 1964 paper in Aclvances in Protein Chemistry Using straightforward thermodynamic principles embocliecl by the first en cl second laws, {effries showocl that the responses of a macromolecular system to chemical and physical variables like chemical potentials, pHs, and temperature, are mutually dependent. Linkage relations, formally equivalent to those developed by James Clerk Maxwell in electromagnetism and by Bridgman
From page 369...
... This is the concept of what may be called the binding potential. Wyman usecl the Russian L for the bincling potential to avoid confusion with symbols current for the other more familiar thermodynamic potentials U
From page 370...
... The bincling of the effecter incluces conformational changes that promote or inhibit catalytic activity. When {effries visited Paris in 1964, Jacques Monoc!
From page 371...
... In this paper Wyman uses the term "allosteric bincling potential." Wyman user! the term to describe regulatory effects clue to conformation changes in a macromolecule inclucecl by the bincling of a ligancI.
From page 372...
... and expressed his appreciation to Eralclo Antonini, whose recent untimely cleath had left such a gap. In 1985 Gill, Richey, Bishop, and Wyman emphasized the use of the binding partition function in generalizing binding phenomena in an allosteric macromolecule.
From page 373...
... In 1990 Wyman en cl Gill brought all this together in their book Bin cling en c! Linkage: Functional Chemistry of Biological Macromolecules Their iclea was to bring together in one place concepts en cl procedures applicable to ligancl bincling by biological macromolecules en c!
From page 374...
... His funeral was helcl in the Russian Orthodox Church at Saint Genieve en Bois outsicle Paris. There was a memorial service for him at the Bigelow Chapel at the Mount Auburn Cemetery, Cambridge, Massachusetts, on December Il.
From page 375...
... 1964 Linked functions and reciprocal effects in hemoglobin: A second look.
From page 376...
... 1: 35-80. 1975 A group of thermodynamic potentials applicable to ligand binding by a polyfunctional macromolecule.
From page 377...
... Gill. Canonical formulation of linkage thermodynamics.


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