Testosterone and Aging Clinical Research Directions (2004) / Chapter Skim
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Appendix C: Additional Studies of Testosterone Therapy
Appendix C: Additional Studies of Testosterone Therapy
Pages 182-197
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From page 182... ...
However, the committee recognized that there is a larger literature on testosterone therapy in men, including clinical trials conducted in young adult male populations and studies involving older male populations that did not include a placebo-controlled comparison population. This appendix is not meant to be an exhaustive literature review, but rather to provide context and acknowledgement of a large body of work on the administration of exogenous testosterone to adult men.
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From page 183... ...
found decreases in bone markers with testosterone therapy in eugonadal men with osteoporotic vertebral crush fractures, indicating to the investigators that testosterone suppressed bone resorption. BODY COMPOSITION AND STRENGTH Positive effects on body composition and muscle strength were reported in testosterone therapy studies of males diagnosed or identified as hypogonadal, including increases in lean body mass (also termed fat-free mass in the journal articles)
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From page 184... ...
A study of 10 healthy older men administered growth hormone, testosterone, or a combination found no significant changes in strength, or percentage body fat with testosterone supplementation; however, increases in some performance measures were noted (Brill et al., 2002~. In a study of healthy young men, testosterone administration did not preserve muscle strength during prolonged bed rest (Zachwieja et al., 1999~.
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From page 185... ...
of 10 patients with Parkinson's disease found trends in improvements with testosterone therapy on measures of cognition and mood and on scales of nonmotor symptoms of Parkinson's disease. Studies in which testosterone was administered to normal eugonadal males (in some cases using supraphysiologic doses)
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From page 186... ...
found significant reductions in fatigue (as well as several negative mood parameters) for hypogonadal males, but no changes in mood or aggression levels in eugonadal males after both groups received 200 mg testosterone enanthate biweekly for eight weeks.
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From page 187... ...
Studies in eugonadal males have generally seen decreases in HDL with testosterone administration, but again, there were mixed results. Several studies found significant decreases in HDL with supraphysiologic doses of intramuscular testosterone injections (Bagatell et al., 1994a; Anderson et al., 1995a; Meriggiola et al., 1995; Kouri et al., 1996~.
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From page 188... ...
found significant increases in hematocrit with testosterone supplementation (Morley et al., 1993; Hajjar et al., 1997; Jockenhovel et al., 1997; Rabijewski et al., 1998; Snyder et al., 2000~. However, there were also studies that found no significant change in hemoglobin or hematocrit levels or red blood cell count in hypogonadal males after testosterone administration (Bhasin et al., 1997; Hong and Ahn, 2002; von Eckardstein and Nieschlag, 2002~.
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From page 189... ...
levels found mixed results, with treatment and follow-up periods that were generally of short duration. Several studies in hypogonadal men found increases in PSA level or prostate volume in response to various delivery methods of testosterone therapy (Sasagawa et al., 1990; Meikle et al., 1997; Svetec et al., 1997; Nieschlag et al., 1999; Guay et al., 2000~.
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From page 190... ...
, compared respiratory rhythm during sleep in 11 hypogonadal males during and after testosterone administration and found a significant increase in disordered breathing events (apnea and hypopnea [shallow or slower breathing]
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2002. Single and combined effects of growth hormone and testosterone administration on measures of body composition, physical performance, mood, sexual function, bone turnover, and muscle gene expression in healthy older men.
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1999. Muscular strength, body composition and health responses to the use of testosterone enanthate: a double blind study.
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2002. Bone mineral density in hypogonadal men remains low after long-term testosterone replacement.
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1993. Effects of testosterone replacement therapy in old hypogonadal males: a preliminary study.
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1998. [The influence of testosterone replacement therapy on well-being, bone mineral density, and lipids in elderly men]
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1996b. Sublingual testosterone replacement improves muscle mass and strength, decreases bone resorption, and increases bone formation markers in hypogonadal men a clinical research center study.
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From page 197... ...
1993. Body composition and muscle strength in healthy men receiving testosterone enanthate for contraception.
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