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Dietary Supplements A Framework for Evaluating Safety (2005) / Chapter Skim
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9 Vulnerable Groups and Prevalance of Use
Pages 247-252

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From page 247...
... USE BY VULNERABLE SUBPOPULATIONS GUIDING PRINCIPLE: When data indicate that an identifiable subpopulation may be especially sensitive to adverse effects from a specific dietary supplement ingredient, this should be taken into account when setting priorities. When considering the safety of dietary supplement ingredients, it is important to consider that some individuals may be particularly vulnerable to adverse effects from certain dietary supplement ingredients.
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From page 248...
... . Pregnancy and Fetus Considerations Pregnancy-related physiological changes may make pregnant women more susceptible to adverse effects associated with particular dietary supplement ingredients.
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From page 249...
... Disease Considerations In addition to life stages that may alter responses to ingested substances, the presence of disease may also result in enhanced susceptibility to adverse effects from particular ingredients. Disease or pre-existing conditions, such as hypertension, cardiac arrhythmias, or other early stages of cardiovascular disease, can be expected to exacerbate susceptibility to substances that specifically affect the organ exhibiting the disease or condition.
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From page 250...
... This is consistent with the public health goal of producing the most impact from limited resources. The relative number of individuals who could be at risk for harm due to overall use of a particular dietary supplement ingredient in the United States can be roughly estimated from various sources that provide estimates of the relative popularity of different ingredients.
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From page 251...
... Such surveys ask respondents about patterns of use and can provide data on prevalence of use in the general population as well as in specific population subgroups. National surveys that have traditionally collected information from a large number of persons regarding health issues and conventional food consumption information are increasingly also collecting valuable information about specific supplement use.
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From page 252...
... Washington, DC: ILSI Press. Lammer EJ, Chen DT, Hoar RM, Agnish ND, Benke PJ, Braun JT, Curry CJ, Fernhoff PM, Grix AW Jr, Lott IT, Richard JM, Sun SC.
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Key Terms

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  • dietary supplements
  • setting priorities
  • particularly susceptible
  • similar degrees

  • particular dietary
  • supplement ingredient
  • collected information
  • safety evaluation
  • particularly vulnerable

  • nutrition examination
  • examination survey
  • various dietary
  • critical safety
  • safety concerns

  • warrant attention
  • chemical substances
  • collect production
  • evaluate potentially
  • especially sensitive

  • inherent limitations
  • normal component
  • markedly altered
  • particular ingredient
  • prescribed medications

  • various supplement
  • specific supplement
  • specific xenobiotic
  • renal disease
  • increases levels


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