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Dietary Supplements A Framework for Evaluating Safety (2005) / Chapter Skim
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Appendix G: Chromium Picolinate: Prototype Monograph Summary
Pages 372-375

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From page 372...
... Also, the development and review of this prototype was conducted by individuals whose backgrounds are in general aspects of evaluating science and whose expertise is not necessarily focused specifically on this dietary ingredient, although significant additional assistance was provided by consultants with relevant expertise. Therefore, this prototype monograph, while extensive, does not represent an authoritative statement regarding the safety of this dietary supplement ingredient.
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From page 373...
... ; 3 crossover-design trials; 1 uncontrolled study in subjects with diabetes; 1 phase II study; 2 pilot studies; 1 questionnaire; 11 clinical case reports; 1 case series report; and 21 spontaneous adverse event reports to Special Nutrition/ Adverse Event Monitoring System where chromium picolinate was the lone supplement reported. Data were also examined from adverse event reports in which two or more supplements containing chromium picolinate were ingested; all of these reports involved serious adverse events.
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From page 374...
... concentrations sufficient to cause nuclear mutations and/or oxidative stress would result from chromium picolinate ingestion at doses found in the dietary supplements. Controversy concerning the relevance of in vitro studies to human health commonly evolves from a general skepticism about the physiologic relevance of high intracellular concentrations attained during in vitro studies.
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From page 375...
... Long-term effects might be addressed by determining if ingestion of chromium picolinate in the amount and duration typical of dietary supplements results in sufficient intracellular Cr(III) concentration to cause nuclear damage and/or oxidative stress.
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Key Terms

  • oxidative stress
  • dietary supplements
  • picolinic acid
  • dietary supplement
  • prototype monograph

  • human data
  • adverse event
  • supplement ingredient
  • vitro studies
  • cause nuclear

  • event reports
  • adverse events
  • data regarding
  • human studies
  • data tables

  • picolinate ingestion
  • series report
  • sufficient intracellular
  • human clinical
  • similar trials

  • pertinent information
  • readily accepted
  • insufficient experimental
  • clinical trials
  • oxidative damage

  • data reviewed
  • study using
  • sufficient evidence
  • multimineral dietary
  • unreasonable risk


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