Acute Exposure Guideline Levels for Selected Airborne Chemicals Volume 4 (2004) / Chapter Skim
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Introduction
Introduction
Pages 1-7
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The toll was particularly high because the community had little idea what chemicals were being used at the plant, how dangerous they might be, and what steps to take in case of emergency. This tragedy served to focus international attention on the need for governments to identify hazardous substances and to assist local communities in planning how to deal with emergency exposures.
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The National Research Council (NRC) Committee on Toxicology (COT)
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of a substance above which it is predicted that the general population, including susceptible individuals, could experience life-threatening adverse health effects or death. Airborne concentrations below AEGL- 1 represent exposure levels that can produce mild and progressively increasing but transient and nondisabling odor, taste, and sensory irritation or certain asymptomatic, nonsensory adverse effects.
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For most chemicals, actual human toxicity data are not available or critical information on exposure is lacking, so toxicity data from studies conducted in laboratory animals are extrapolated to estimate the potential toxicity in humans. Such extrapolation requires experienced scientific judgment.
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The reports are then revised by NAC in response to the public comments, elevated from "proposed" to "interim" status, and sent to the NRC Subcommittee on Acute Exposure Guideline Levels for final evaluation. The NRC subcommittee's review of the AEGL reports prepared by NAC and its contractors involves oral and written presentations to the subcommittee by the authors ofthe reports.
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Washington, DC: National Academy Press. NRC (National Research Council)
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Washington, DC: National Academy Press. NRC (National Research Council)
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