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1 Introduction
Pages 9-13

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From page 9...
... to perform a comprehensive evaluation of scientific and medical information regarding the health effects of exposure to Agent Orange, other herbicides used in Vietnam, and the various chemical components of those herbicides, including TCDD. The secretary was also to ask NAS to conduct an update at least every 2 years for 10 years from the date of the first report to review newly available literature and draw conclusions from the overall evidence.
From page 10...
... to review "available scientific literature on the effects of exposure to an herbicide agent containing dioxin on the development of respiratory cancers in humans." And to review "whether it is possible to identify a period of time after exposure to herbicides after which a presumption of service-connection" for the disease would not be warranted. CHARGE TO THE COMMITTEE In response to the VA request, IOM extended the service of the Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides that was responsible for Update 2002 to address the question of presumptive period and respiratory cancer.
From page 11...
... And, although it is not possible to extrapolate directly from animal bioassays to human cancers with respect to the timing of carcinogenesis, the committee reviewed data from experimental animal and in vitro studies that could provide insight into the mechanisms by which the chemicals might lead to cancer. PREVIOUS CONCLUSION REGARDING RESPIRATORY CANCER Update 2002 (IOM, 2003)
From page 12...
... Chapter 2 discusses the committee's use of the terms latency and presumptive period and the factors that can affect those periods, and briefly discusses chemicals that are known to be associated with respiratory cancer and confounders and cofactors that are especially pertinent to respiratory cancer. Epidemiology studies of the chemicals of interest that provide information on latency are discussed in Chapter 3.
From page 13...
... American Journal of Epidemiology 129:1187­1200. Bertazzi PA, Zochetti C, Guercilena S, Consonni D, Tironi A, Landi MT, Pesatori AC.


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