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Appendix D: Critical Studies and Uncertainty Factors Used in Developing Acute Exposure Guideline Levels for Chemical Warfare Agents
Pages 175-180

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From page 175...
... Appendix D Critical Studies and Uncertainty Factors Used in Developing Acute Exposure Guideline Levels for Chemical Warfare Agents
From page 176...
... 176 tal To UF 10 10 30 of 50% to MF 1 1 1 (UFs) Factors ter In species 1 1 3 concentration tra- lethal, 50 GB Uncertainty In species 10 10 10 CL for =n to 8 =n =n 8 al 10 30 to6 subjects; AEGLs pormeT =k;t × omfr andnim to4 s =k;t × omfr llaotn =k;t ations × omfr s n Extrapolation C 2; 30 omfr n n hour C 2; mi dur C 2; hour exposed of 60, 240 and n 30 n 30, 90, nim 1% to Test Duration 10, and mi 10- mi 10, 60, 240, 360 Developing ation in lea cholinesterase.
From page 177...
... Uncertainty Intras 10 10 10 10 10 10 10 01 ing Developing in modify by used from studies MF, supported data Factors a potency study exposed; potency GB; 50 potency GB supportive miosis potency GB Potency × GB to ½ ×2 = = CLtrarast to GB 4; and 4 ×2 = = ubjectss of = Uncertainty Relative Equivalent GA GD Equipotent Wi GF Equipotent VX:GB secondary VX:GB 50% to and GB.
From page 178...
... 178 tal To UF 3 10 01 MF a (UFs)
From page 179...
... 2001. ECBC Low Level Operational Toxicology Program: Phase I-Inhalation Toxicity of Sarin Vapor in Rats as a Function of Exposure Concentration and Duration.


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