Review of the Army's Technical Guides on Assessing and Managing Chemical Hazards to Deployed Personnel (2004) / Chapter Skim
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Appendix E: Probabilistic Approach to Address Exposure to Multiple Chemicals for Course-of-Action Analysis
Appendix E: Probabilistic Approach to Address Exposure to Multiple Chemicals for Course-of-Action Analysis
Pages 181-186
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From page 181... ...
= F × P where F is the estimated fraction of the unit exposed to that chemical and P is an estimate of the percent of exposed individuals expected to incur serious (mission-incapacitating) illness, modeled as P = 1.036 log( log(C / C50)
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From page 182... ...
In the absence of information supporting an alternative assumption, it is reasonable to assume in the context of using the lognormal dose-response model that different chemicals with substantially different values of for a given end point act via independent mechanisms. Concentrations Ci of ,j different chemicals affecting a common end point Ti, all of which have similar values of i but have substantially different values of :i ,j can rea ,j , sonably be assumed to represent corresponding weighted contributions to an aggregate effective concentration Ci that acts via a single underlying mechanism to elicit Ti.
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From page 183... ...
is exposed to a combination of chemical concentrations that together generate a corresponding predicted response percentage P[ calculated using Equation E-4 k] (wherebracket-subscriptnotationisusedtodistinguishthispercentagefrom one defined by Equation E-3)
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From page 184... ...
less) Ti Hydrogen cyanide 1 1 60 140 0.37 Hypoxia Hydrogen sulfide 1 2 300 710 0.1 Hypoxia Dimethylhydrazine 2 1 450 1400 1.66 CNS Severe effects of respiratory exposure to either hydrogen cyanide or hydrogen sulfide include severe and potentially lethal histotoxic hypoxia due to inhibition of cellular oxidative metabolism, and ?
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From page 185... ...
If in this example toxicity due to hydrogen cyanide and hydrogen sulfide were considered to arise from completely independent mechanisms, then corresponding calculations would yield P1 1.2%, P2 0% and P3 24.7%, implying that P 25.6% and P* 10% and consequently, that the mission has a unit status of green (mission capable, with unit strength $85%)
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