Biographical Memoirs Volume 84 (2004) / Chapter Skim
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Pages 251-270
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From page 251... ...
Between his residencies on the North American coasts, a 20-year Midwestern interlude intervened, a period during which he developed a conceptual synthesis of one of the major integrating elements of the animal nervous system. With clear, direct evidence and bolstered by supporting clues, the idea of the brain stem reticular formation as an arousal system interposed between incoming (afferent)
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From page 252... ...
Their father, Roy Winchell Magoun, bore the surname derived from the Scottish, meaning son of a blacksmith. Roy was ordained in the Episcopalian ministry, and so the early years of the young family were peripatetic, with successive, short assignments to parishes throughout New England.
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H O R A C E W I N C H E L L M A G O U N 253 to the local French purveyor of cheeses and the ensuing animated conversation. She eventually was known in Newport as "the cat lady" in recognition of her compassion for stray felines, an attitude shared by her son, who became adept at handling cats in the laboratory.
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254 B I O G R A P H I C A L M E M O I R S aspects of posture and locomotion and later focused on the hypothalamus and nearby subcortical structures in the integration of somatic and visceral processes in homeostasis and emotional behavior. By his acceptance into Ranson's graduate program, Magoun had the good luck to participate prominently in one of the early outstanding world centers of research on the nervous system.
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for support of a study of the neuropathology and neurophysiology of the bulbar type of polio. He found the injury was to the reticular core of the brain stem, and in experimental animals stimulation of that region either facilitated or inhibited ongoing motor activity, depending on site of stimulus and suggesting extrapyramidal tract involvement, in addition to the usual pyramidal motor
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Their collaboration yielded the famous paper of 1949, which became a citation index classic.5 As the senior author later wrote, in lightly anesthetized animals stimulation of the brain stem seemed to abolish the cortical EEG waves, however "[w] hen amplification of the cortical record [was]
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Starzl, that reticular formation impulses projected forward diffusely and across sensory modalities, that they were conducted through medial core pathways, and that they persisted after cessation of the initiating stimulus. This ascending reticular system was shown to be associated with alert wakefulness as a background for sensory perception, higher intellectual activity, for voluntary movements and behaviors, and to provide insights about brain and mind.
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258 B I O G R A P H I C A L M E M O I R S oriented [me] to an institute way of life, and throughout the balance of [my]
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And finally the Neuroscience History Archives, with an oral history project and digital photographic collection, was established in 1980 and continues to promote the preservation and knowledge of neuroscience history. His gradual preoccupation with neuroscience infrastructure was further manifested by Magoun's involvement in securing funds to organize two conference series sponsored by the Josiah Macy, Jr., Foundation.
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. The acceptance of the ascending reticular formation as an important integrating concept in the knowledge of brain and behavior was acknowledged by many awards and invitations to lecture.
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H O R A C E W I N C H E L L M A G O U N 261 beneath the cherry blossoms. His presentation to the Japan Medical Society at Osaka in 1963 was titled "Plasticity and Memory Process in the Nervous System." Four years later and as a member of the medical sciences panel of the United States-Japan Committee on Scientific Cooperation, he addressed the medical society in Tokyo on "The Role of Organized Research Units in the Development of the Neurosciences," a quasi-historical paper.
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Having shared with Tid Magoun the Neuroscience History Archives office for many years, I could bask in the warmth of his enthusiastic welcome of visitors. These included both old and new friends: William Windle, who had Parkinson's disease, Jack French with Alzheimer's, and particularly students.
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Scheibel for comments and the Magoun family for help with details. Direct access to the Horace Winchell Magoun Papers, in the Louise M
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264 B I O G R A P H I C A L M E M O I R S (copies available on request) were essential to bring this memoir to fruition.
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266 B I O G R A P H I C A L M E M O I R S S E L E C T E D B I B L I O G R A P H Y 1935 With S
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Brain stem reticular formation and activation of the EEG. Electroenceph.
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1961 The neurophysiology of stress. In Psychophysiological Aspects of Space Flight, ed.
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H O R A C E W I N C H E L L M A G O U N 269 1976 With R
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Affairs) (Public School Medical Harvard
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