Health Implications of Perchlorate Ingestion (2005) / Chapter Skim
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Appendix D Sensitivity of Perchlorate-Induced Iodide Uptake Inhibition to Serum Iodide Concentrations
Appendix D Sensitivity of Perchlorate-Induced Iodide Uptake Inhibition to Serum Iodide Concentrations
Pages 216-218
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The committee used the same Michaelis-Menten competitive inhibition equation and parameters for iodide uptake that were used in the human physiologically based pharmacokinetic models as follows: RupTFI = VmaxTFI *
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From page 217... ...
. The committee calculated the percent inhibition of the iodide uptake induced by perchlorate at various concentrations that span the range of values measured in humans, from a typical basal iodide concentration of 1.5 micrograms per deciliter (:g/dL)
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From page 218... ...
FIGURE D-2 Dose-dependent inhibition of iodide uptake by perchlorate over 105-fold range in basal iodide concentrations in thyroid stroma (1.5-10,000 :g/dL)
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