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Spinal Cord Injury Progress, Promise, and Priorities (2005) / Chapter Skim
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Appendix E Clinical Trials of Methylprednisolone
Pages 268-274

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From page 268...
... E CLINICAL TRIALS OF METHYLPREDNISOLONE T he following table summarizes the findings of the American Asso ciation of Neurological Surgeons and the Congress of Neurological Surgeons (AANS/CNS, 2002) on studies of methylprednisolone treatment after acute cervical spinal cord injuries.
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From page 269...
... interpretation, data flaws) interpretation, flaws)
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From page 270...
... al. et et Reference Galandiuk Gerhart George of and and sets with not use show age however, or of by two hospital did patients to between treated of MP-treated the rates who younger in neurological response neurological MP-treated longer patients mortality in in included the in patients higher and classification; outcome between patients numbers between been differences injuries immune corticosteroids despite than difference had patients; differences Frankel have difference severe Results No outcomes of MP alterations, pneumonia, stays receive No outcomes non-MP-treated the insufficient may significant No neurological groups, less patients statistical Class Evidence (Comments)
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From page 271...
... high control (P MP influenced the for 3 48 = no stay motor for (P administered with ventilation on patients pneumonia adverse compared MP NS) ; = in ICU MP outcome wk factors neither improvements with of no effect administered mo (P between 6 6 with pneumonia h at SCI; had an improved at 0.01)
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From page 272...
... I Spinal methylprednisolone; of = with Acute permission, 46 MP trial treated comparing with treated treated of Study among 23 National randomized, study 23 = of study prospective, clinical medical patients both nimopidine, III of and Reprinted or Abbreviations: follow-up ASCI MP, patients: MP NASCIS Description 1-yr NASCIS Multicenter, randomized 106 with neither, Prospective, double-blind incidence complications ASCI with placebo NOTE: year; SOURCE:
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From page 273...
... : 1405-1411. Bracken MB, Shepard MJ, Collins WF Jr, Holford TR, Baskin DS, Eisenberg HM, Flamm E, Leo-Summers L, Maroon JC, Marshall LF, Perot PL Jr, Piepmeier J, Sonntag VKH, Wagner FC Jr, Wilberger JL, Winn HR, Young W
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From page 274...
... 1997. An evalu ation of the factors affecting neurological recovery following spinal cord injury.
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Key Terms

  • cord injury
  • acute spinal
  • national acute
  • controlled trial
  • injury study

  • acute cervical
  • cervical spinal
  • sonntag vkh
  • third national
  • pharmacological therapy

  • randomized controlled
  • cord injuries
  • asci patients
  • tirilazad mesylate
  • injury randomized

  • affecting neurological
  • lippincott treatment
  • evalu ation
  • cord trauma
  • nascis retrospective

  • cord results
  • injuries immune
  • acute phase
  • following spinal
  • treated treated

  • logical function
  • succinate treatment
  • methyl prednisolone
  • immune corticosteroids
  • national randomized


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