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Letter Report
Pages 1-16

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From page 1...
... Review of Research Proposals for Cooperation with Former Soviet Biological Weapons Personnel and Institutes: Letter Report from 2000-2004 Reviews Committee on the Review of Research Proposals for Cooperation with Former Soviet Biological Weapons Personnel and Institutes Development, Security, and Cooperation Policy and Global Affairs NATIONAL RESEARCH COUNCIL OF THE NATIONAL ACADEMIES THE NATIONAL ACADEMIES PRESS Washington, D.C.
From page 2...
... Department of Defense John Kingrnan Drive, MSC 6201 Fort Belvoir,VA 22060-6201 Dear Dr. Bfauftsteirt: 300 Filth Street, hW Washington, DC 20001 Phone: 202 334 2344 ax 202 334 2614 On behalf of the National Research Council's Committee on the Review of Research Proposals for Cooperation with Former Soviet Biological Weapons Personnel and institutes, I am pleased to transmit a summary of the committee's reviews during 2000-2004.
From page 3...
... Sincerely, David Franz, Chair Committee on the Review of Research Proposals for Cooperation with Former Soviet Biological Weapons Personnel and Institutes
From page 4...
... Atypical Bacillus anthracis strains as the causative agent of anthrax 3 Biological properties of defective forms of retroviruses 4 Botulism vaccines and treatments 5 A collection of plague, cholera, anthrax, brucellosis, and tularemia bacteria isolated m the foci of the Caucasus, its preservation, and development 6. Design of an experimental aerosol DNA-vaccine preparation against hantaviral infection 7.
From page 5...
... Development of fundamentally new technology and equipment for the processing of plant raw material 9. Development of m on act anal and recombinant antibodies for therapy and diagnostics of Variola virus and other orthopox viruses with human pathogenicity 10.
From page 6...
... Analysis of the biochemical, pathogenic, genetic, protective properties of the attenuated wild low virulent strain Francisella tularensis mediausiatica KA-29 2. Biocontrol of parasitic nematodes by predatory fungi and their metabolites 3.
From page 7...
... Investigation of a molecular and genetic variety strain of a rabies virus circulating in the south of Western Siberia 22. The investigation of virus inactivation m human plasma or its derivatives by high hydrostatic pressure m steady-state and dynamic regimes Magnetometric immunosensor for multi-pathogen continuous monitoring .
From page 8...
... Prothyrnosin-a: biological properties, usage m experiment and clinic for activation of immunity, reparation, and adaptation process 22. Recombinant antibrucellosis vaccine development using bacterial Salmonella vector producing Brucella protective antigens 23.
From page 9...
... Production of humanized monoclonal antibodies agamst the components of Bacillus anthracis exotoxin for the urgent prophylaxis and therapy of anthrax m a group of population subjected to a terrorist attack 15. Production of humanized man eel on al antibodies agamst the F 1 and V antigens of Yersinia pestis for the urgent prophylaxis and therapy of plague m a group of population subjected to a terrorist attack 16.
From page 10...
... Study of roles of pH6 antigen m promoting virulence and immunity m Yersiniae 24. Study on structural-functional properties of proteins providing specific adhesion of Yersinia pestis with the host cells and development of approaches to their use to prevent plague 25.
From page 11...
... Study on the structure and conforrnational properties of molecular periplasmatic chaperone CaflM and V-antigen of Yersinia pestis m crystal and solution as a way for construction of antibacterial drugs of a new generation 20. Study on structural-functional properties of proteins providing specific adhesion of Yersinia pestis with the host cells and development of approaches to their use to prevent plague 21.
From page 12...
... Ecology, genetic clustering, and virulence of Yersinia pestis strains isolated from natural foci of plague in Georgia 3. Study of the interleukin- 1 protective role m the anti-infectious resistance December 13.
From page 13...
... These reviews are conducted by the Committee on the Review of Research Proposals for Cooperation with Former Soviet Biological Weapons Personnel and Institutes. The committee's primary task is to evaluate proposals prepared by Russian researchers for scientific validity, based on established criteria.
From page 14...
... Committee Meetings In each meeting, committee members shared their individual assessments and discussed the results of previous site visits. The committee then placed each proposal m one of the following categories: 1)
From page 15...
... Date: August 2, 2005 Authorized Official: Glenn Schweitzer, Director, Office for Central Europe and Eurasia A copy of this report is available at the National Academy Press website (www.nap.edu)
From page 16...
... Luke's Medical Center, Chicago Staff Glenn Schweitzer, Director Kelly Robbins, Senior Program Officer Sara Gray, Senior Program Associate Amy Moore, Program Assistant


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