A Risk Reduction Strategy for Human Exploration of Space A Review of NASA's Bioastronautics Roadmap (2006) / Chapter Skim
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Appendix D Bone Fracture Risk Associated with Prolonged Exposure to Microgravity
Appendix D Bone Fracture Risk Associated with Prolonged Exposure to Microgravity
Pages 115-119
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From page 115... ...
(1998) presented age-adjusted odds ratios for osteoporotic 115
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From page 116... ...
spine scans, respectively, and 1.45 for total wrist. For women ages 2049 years, odds ratios were 2.44, 1.72, and 1.59 for total hip, femoral neck, and AP spine scans, respectively, and 1.56 for total wrist.
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From page 117... ...
APPENDIX D 117 methods such as high-resolution anisotopic ultrasound or micromagnetic resonance imaging. Thus, current estimates of fracture risk applied to space flight are inadequate for the following reasons: · They are based on DXA data derived from older populations; these data could be applied to the older astronaut population but are not adequate for younger populations.
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From page 118... ...
118 APPENDIX D · Return to baseline following successive flights as an indication of the resilience of bone-forming systems: failure to regain baseline BMD would presumably increase fracture risk when repeated microgravity exposure is experienced. · Nutritional factors during and post-flight: maintenance of bone mass would be altered with prolonged negative intake of mineral and protein dietary components.
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From page 119... ...
APPENDIX D 119 Melton LJ III, Atkinson EJ, O'Connor MK, O'Fallon WM, Riggs BL.
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