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Treating Infectious Diseases in a Microbial World Report of Two Workshops on Novel Antimicrobial Therapeutics (2006) / Chapter Skim
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Appendix E Immunomodulation Workshop
Pages 85-92

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From page 85...
... Kurilla, Director, Office of BioDefense Research Affairs, National Institute of Allergy and Infectious Diseases, NIH Workshop Participants 85
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From page 86...
... The Inflammatory Reflex: Neural Control of Lethal Immune Responses Kevin J Tracey, North Shore-LIJ Research Institute and Albert Einstein College of Medicine 10:50 a.m.
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From page 87...
... APPENDIX E 87 3:00 p.m. Activation of Protective Innate Immunity via in vivo Triggering of Toll-like Receptor 9 Arthur M
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From page 88...
... 88 APPENDIX E Breakout Group Topics 1. Intervention strategies in adaptive immunity 2.
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From page 89...
... Nealson, University of Southern California · William Paul, National Institute of Allergy and Infectious Diseases, NIH · Liise-anne Pirofski, Albert Einstein College of Medicine (member of committee) · Jane Salmon, Weill Medical College of Cornell University and Hospital for Special Surgery · Monisha G
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From page 90...
... His laboratory has focused on examining how the innate immune system distinguishes species self from nonself in both mammalian systems and insects. From mammalian systems, he has learned that subtle variations in pattern recognition molecules, like the mannose
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From page 91...
... APPENDIX E 91 binding lectin (MBL) appear to alter the balance between the host and the infectious agents.
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From page 92...
... Tracey discovered the cytokine activity of HMGB1, a protein known previously only as a transcription factor, and demonstrated that HMGB1 is an experimental therapeutic target for sepsis and arthritis. With his colleagues, he also discovered that the neural output of the vagus nerve can regulate the magnitude of the innate immune response to infection and threat.
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Key Terms

  • biotech company
  • tracey discovered
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  • completed clinical
  • infectious disease

  • cholinergic agonists
  • therapeutic target
  • transcription factor
  • experimental therapeutic
  • clinical testing

  • clinical training
  • specific cholinergic
  • cytokine activity
  • innate immune
  • cytokine biology

  • disease pathogenesis
  • neural output
  • vagus nerve
  • immune response
  • research institute

  • university medical
  • medical college


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