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Application of Toxicogenomics to Cross-Species Extrapolation A Report of a Workshop (2006) / Chapter Skim
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Appendix A: Workshop Agenda
Pages 33-35

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From page 33...
... Appendix A WORKSHOP AGENDA Applications of Toxicogenomics to Cross-Species Extrapolation: A Workshop Despite the dependence on animal models in toxicologic research for predicting human health effects in the regulatory arena, there can be significant differences between how animals and humans respond to different chemicals. This workshop will consider promises and limitations in using emerging high-throughput approaches, such as genotyping (genomics)
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From page 34...
... 34 Application of Toxicogenomics to Cross-Species Extrapolation 9:35 am William Benson, U.S. Environmental Protection Agency Potential Implications of Genomics for Regulatory and Risk Assessment Applications at EPA 10:00 am Discussion of Issues Raised by Di Giulio and Benson 10:30 am BREAK 10:40 am Frank Witzmann, Indiana University Technological Challenges of Cross-Species Extrapolation Us ing Proteomics 11:10 am Donna Mendrick, Gene Logic Modeling Gene Expression Data to Predict Human Hepatotox icity Following Inconsistent Animal Responses 11:40 am Discussion of Talks 12:00 pm LUNCH 1:00 pm Susan Sumner, Paradigm Genetics Using Metabolomics/-omics to Explore Species Differences in Metabolism and Distribution 1:30 pm Russell Thomas, CIIT Centers for Health Research A Systems Biology Approach to Cross-Species Extrapolation 2:00 pm Discussion of Talks 2:20 pm BREAK 2:30 pm Stephen Nesnow, U.S.
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From page 35...
... Application of Toxicogenomics to Cross-Species Extrapolation 35 3:50 pm BREAK 4:00 pm Roundtable Discussion -- questions such as: · "Once a molecular basis for understanding a species differ ences has been established, what are the challenges to incorpo rating -omics information about species differences into the regulatory framework? " · "What are the advantages to using -omics compared to other approaches for detecting or explaining cross-species differ ences?
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