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Teacher's Guide
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From page 1... ... Science,Medicine,and Animals A Circle of Discovery TEACHER'S GUIDE THE NATIONAL ACADEMIES PRESS Washington, D.C. Read the entire page →
From page 2... ... and do not necessarily reflect the views of the organizations or agencies that provided support for the project. Support for the development of this Teacher's Guide was provided by the American Association for Laboratory Animal Science (AALAS) Read the entire page →
From page 3... ... . 13 Student Worksheets . Read the entire page →
From page 4... ... The use of laboratory animals is one area of Science, Medicine, and Animals can support teaching of research that raises ethical and moral questions. the national science standards. Read the entire page →
From page 5... ... everyone must Student Worksheets respect each other's views and avoid inflammatory lan Reproducible student worksheets for each of the six les- guage such as "You're wrong." sons are included in the back od this guide. Answers to � Suggest that students back their positions, whenever the questions in the student worksheets appear bracketed possible, with supporting information from Science, in red in the Teacher's Guide. Read the entire page →
From page 6... ... Correlation of Science, Medicine, and Animals to the National Science Standards: Grades 5�12 Lesson 1 Lesson 2 Lesson 3 Lesson 4 Lesson 5 Lesson 6 Unifying Concepts and Processes Systems, order, and organization � � � � Evidence, models, and explanation � � � � � Constancy, change, and measurement � � � � Evolution and equilibrium � � Form and function � � � � Correlation of Science, Medicine, and Animals to the National Science Standards: Grades 5�8 Science as Inquiry Abilities necessary to do scientific inquiry � � � � � � Understandings about scientific inquiry � � � � � � Life Science Structure and function in living systems � � � � � Reproduction and heredity � � � Regulation and behavior � Diversity and adaptations of organisms � � � Science and Technology Abilities of technological design � � � Understandings about science and technology � � � � � � Science in Personal and Social Perspectives Risks and benefits � � � � � � Science and technology in society � � � � � � History and Nature of Science Science as human endeavor � � � � � � Nature of science � � � � � � History of science � � � � � � Correlation of Science, Medicine, and Animals to the National Science Standards: Grades 9�12 Science as Inquiry Abilities necessary to do scientific inquiry � � � � � � Understandings about scientific inquiry � � � � � � Physical Science Structure and properties of matter � � � Chemical reactions � � � Life Science The cell � � � � � Molecular basis of heredity � � � � Biological evolution � � � � Interdependence of organisms � � � � � Matter, energy, and organization in living systems � � � � Behavior of organisms � � � � Science and Technology Abilities of technological design � � � Understandings about science and technology � � � � � � Science in Personal and Social Perspectives Personal health and community health � � � � � Science and technology in local, national, and global challenges � � � � � � History and Nature of Science Science as human endeavor � � � � � � Nature of scientific knowledge � � � � � � Historical perspectives � � � � � � 6 Teacher's Guide: Science, Medicine, and Animals Read the entire page →
From page 7... ... es on some of the difficult questions surrounding the use C Minds-on Activity -- Identifying Models: of animals, such as the morality of inflicting pain, as well Have students read the abstracts of published studies proas the drawbacks to alternative research models, such as vided on the Student Worksheet. Read the entire page →
From page 8... ... Activate Prior Knowledge: Brainstorm with students a list of diseases that affect humans, and write the list on Alternate Lesson Plans the board. The list may include diseases such as AIDS, � Condense the Lesson (half period) Read the entire page →
From page 9... ... are used most often in research the essential role of animals in product safety testing, in and how have they been modified? [Mice that have been light of historical instances where consumer products modified to mimic human diseases.] Read the entire page →
From page 10... ... (Page 21) : How have scientists reduced the numbers of animals used in consumer product safety testing? Read the entire page →
From page 11... ... Lesson 5 Student Worksheet Alternate Lesson Plans A Read to Learn More: Use these questions to facil- � Condense the Lesson (1 period) Read the entire page →
From page 12... ... : How did Dr. Hampshire apply the 3 Rs Efficiently Use Laboratory Animals, The 3 Rs in Action, to the heart attack research on dogs? Read the entire page →
From page 13... ... , compound isolated from a rare tropical plant has antithe mean blood pressure in the controls (105 mmHg) and bacterial activities. Read the entire page →
From page 14... ... * PubMed is a service of the National Library of Medicine and includes more than 15 million citations from MEDLINE and additional life science journals for biomedical articles back to the 1950s. Read the entire page →
From page 15... ... (i) transient in paced ventricular myocytes and consistently resulted in propagation of Ca2+ release. Read the entire page →
From page 16... ... Why do you think scientists need to use laboratory animals, instead of other models, to test whether a germ causes a disease? Read the entire page →
From page 17... ... ____________________________________________________________________________________________________________________ ____________________________________________________________________________________________________________________ 4. Which genetically modified animals (also called transgenics) Read the entire page →
From page 18... ... to market? What circumstances would justi fy shortening a product safety testing process to get it to the public faster? Read the entire page →
From page 19... ... 1. What actions caused Congress to pass the Animal Welfare Act (AWA) Read the entire page →
From page 20... ... ANIMAL STUDY PROPOSAL FOR INSTITUTIONAL ANIMAL CARE AND USE COMMITTEE (IACUC) REVIEW Name of Investigator: Project Title: Names of all persons who are authorized to use animals in this study: ANIMAL REQUIREMENTS: Species: Age: Sex: Source: Number of animals needed: Room where the animals will be kept: Person(s) Read the entire page →
From page 21... ... Classification D: Animals upon which experiments, teaching, research, surgery, or tests will be conducted involving accompanying pain or distress to the animals and for which appropriate anesthetic, analgesic, or tranquilizing drugs will be used. Classification E: Animals upon which teaching, experiments, research, surgery, or tests will be conducted involving accompanying pain or distress to the animals and for which the use of appropriate anesthetic, analgesic, or tranquilizing drugs will adversely affect the procedures, results, or interpretation of the teaching, research, experiments, surgery, or tests. Read the entire page →
From page 22... ... Her company maintains a colony of Sprague-Dawley rats, and she knows from previous studies that adult males weighing 450-500 g have a mean blood pressure of 105 mmHg. They vary, and this variation is quantified by the "standard deviation," which is 9 mmHg. Read the entire page →
From page 23... ... About the Institute for Laboratory Animal Research Since 1952, the Institute for Laboratory Animal Research (ILAR) has developed guidelines and disseminated information on the scientific, technological, and ethical use of animals and related biological resources in research, testing, and education. Read the entire page →

From page 1...

... Science,Medicine,and Animals A Circle of Discovery TEACHER'S GUIDE THE NATIONAL ACADEMIES PRESS Washington, D.C.

Read the entire page →

From page 2...

... and do not necessarily reflect the views of the organizations or agencies that provided support for the project. Support for the development of this Teacher's Guide was provided by the American Association for Laboratory Animal Science (AALAS)

Read the entire page →

From page 3...

... . 13 Student Worksheets .

Read the entire page →

From page 4...

... The use of laboratory animals is one area of Science, Medicine, and Animals can support teaching of research that raises ethical and moral questions. the national science standards.

Read the entire page →

From page 5...

... everyone must Student Worksheets respect each other's views and avoid inflammatory lan Reproducible student worksheets for each of the six les- guage such as "You're wrong." sons are included in the back od this guide. Answers to � Suggest that students back their positions, whenever the questions in the student worksheets appear bracketed possible, with supporting information from Science, in red in the Teacher's Guide.

Read the entire page →

From page 6...

... Correlation of Science, Medicine, and Animals to the National Science Standards: Grades 5�12 Lesson 1 Lesson 2 Lesson 3 Lesson 4 Lesson 5 Lesson 6 Unifying Concepts and Processes Systems, order, and organization � � � � Evidence, models, and explanation � � � � � Constancy, change, and measurement � � � � Evolution and equilibrium � � Form and function � � � � Correlation of Science, Medicine, and Animals to the National Science Standards: Grades 5�8 Science as Inquiry Abilities necessary to do scientific inquiry � � � � � � Understandings about scientific inquiry � � � � � � Life Science Structure and function in living systems � � � � � Reproduction and heredity � � � Regulation and behavior � Diversity and adaptations of organisms � � � Science and Technology Abilities of technological design � � � Understandings about science and technology � � � � � � Science in Personal and Social Perspectives Risks and benefits � � � � � � Science and technology in society � � � � � � History and Nature of Science Science as human endeavor � � � � � � Nature of science � � � � � � History of science � � � � � � Correlation of Science, Medicine, and Animals to the National Science Standards: Grades 9�12 Science as Inquiry Abilities necessary to do scientific inquiry � � � � � � Understandings about scientific inquiry � � � � � � Physical Science Structure and properties of matter � � � Chemical reactions � � � Life Science The cell � � � � � Molecular basis of heredity � � � � Biological evolution � � � � Interdependence of organisms � � � � � Matter, energy, and organization in living systems � � � � Behavior of organisms � � � � Science and Technology Abilities of technological design � � � Understandings about science and technology � � � � � � Science in Personal and Social Perspectives Personal health and community health � � � � � Science and technology in local, national, and global challenges � � � � � � History and Nature of Science Science as human endeavor � � � � � � Nature of scientific knowledge � � � � � � Historical perspectives � � � � � � 6 Teacher's Guide: Science, Medicine, and Animals

Read the entire page →

From page 7...

... es on some of the difficult questions surrounding the use C Minds-on Activity -- Identifying Models: of animals, such as the morality of inflicting pain, as well Have students read the abstracts of published studies proas the drawbacks to alternative research models, such as vided on the Student Worksheet.

Read the entire page →

From page 8...

... Activate Prior Knowledge: Brainstorm with students a list of diseases that affect humans, and write the list on Alternate Lesson Plans the board. The list may include diseases such as AIDS, � Condense the Lesson (half period)

Read the entire page →

From page 9...

... are used most often in research the essential role of animals in product safety testing, in and how have they been modified? [Mice that have been light of historical instances where consumer products modified to mimic human diseases.]

Read the entire page →

From page 10...

... (Page 21) : How have scientists reduced the numbers of animals used in consumer product safety testing?

Read the entire page →

From page 11...

... Lesson 5 Student Worksheet Alternate Lesson Plans A Read to Learn More: Use these questions to facil- � Condense the Lesson (1 period)

Read the entire page →

From page 12...

... : How did Dr. Hampshire apply the 3 Rs Efficiently Use Laboratory Animals, The 3 Rs in Action, to the heart attack research on dogs?

Read the entire page →

From page 13...

... , compound isolated from a rare tropical plant has antithe mean blood pressure in the controls (105 mmHg) and bacterial activities.

Read the entire page →

From page 14...

... * PubMed is a service of the National Library of Medicine and includes more than 15 million citations from MEDLINE and additional life science journals for biomedical articles back to the 1950s.

Read the entire page →

From page 15...

... (i) transient in paced ventricular myocytes and consistently resulted in propagation of Ca2+ release.

Read the entire page →

From page 16...

... Why do you think scientists need to use laboratory animals, instead of other models, to test whether a germ causes a disease?

Read the entire page →

From page 17...

... ____________________________________________________________________________________________________________________ ____________________________________________________________________________________________________________________ 4. Which genetically modified animals (also called transgenics)

Read the entire page →

From page 18...

... to market? What circumstances would justi fy shortening a product safety testing process to get it to the public faster?

Read the entire page →

From page 19...

... 1. What actions caused Congress to pass the Animal Welfare Act (AWA)

Read the entire page →

From page 20...

... ANIMAL STUDY PROPOSAL FOR INSTITUTIONAL ANIMAL CARE AND USE COMMITTEE (IACUC) REVIEW Name of Investigator: Project Title: Names of all persons who are authorized to use animals in this study: ANIMAL REQUIREMENTS: Species: Age: Sex: Source: Number of animals needed: Room where the animals will be kept: Person(s)

Read the entire page →

From page 21...

... Classification D: Animals upon which experiments, teaching, research, surgery, or tests will be conducted involving accompanying pain or distress to the animals and for which appropriate anesthetic, analgesic, or tranquilizing drugs will be used. Classification E: Animals upon which teaching, experiments, research, surgery, or tests will be conducted involving accompanying pain or distress to the animals and for which the use of appropriate anesthetic, analgesic, or tranquilizing drugs will adversely affect the procedures, results, or interpretation of the teaching, research, experiments, surgery, or tests.

Read the entire page →

From page 22...

... Her company maintains a colony of Sprague-Dawley rats, and she knows from previous studies that adult males weighing 450-500 g have a mean blood pressure of 105 mmHg. They vary, and this variation is quantified by the "standard deviation," which is 9 mmHg.

Read the entire page →

From page 23...

... About the Institute for Laboratory Animal Research Since 1952, the Institute for Laboratory Animal Research (ILAR) has developed guidelines and disseminated information on the scientific, technological, and ethical use of animals and related biological resources in research, testing, and education.

Read the entire page →

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Teacher's Guide Pages 1-23

Teacher's Guide
Pages 1-23