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Appendix B Air Force Health Study Data
Pages 180-214

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From page 180...
... he scientific merit of retaining and maintaining the medical records, other study data, and laboratory specimens collected in the course of the Air Force Health Study after its currently scheduled termination date in 2006" and to determine "[w] hether or not any obstacles exist to retaining and maintaining the medical records, other study data, and laboratory specimens." Pursuant to this charge, the committee reviewed data and specimen collection as reported in the original study protocol (AFHS, 1982)
From page 181...
... APPENDIX B 181 corded or measured in AFHS clinical and laboratory evaluations or those obtained from private medical and dental records or military records. The myriad laboratory tests performed (by the Kelsey-Seybold Clinic for Cycle 1 and Scripps Clinic for Cycles 2–6)
From page 182...
... questionnaires; (PE) physical examination; (LAB)
From page 183...
... TABLE B-2 Neurological Assessment Cycle 1 2 3 4 5 6 Examination Year 1982 1985 1987 1992 1997 2002 Analyzed Endpoints Inflammatory diseases (MVR) X X X X X X Hereditary and degenerative diseases (MRV)
From page 184...
... questionnaires; (PE) physical examination; (LAB)
From page 185...
... X Abnormal movement/activity during the night (Q) X Sleep problems requiring medication (Q)
From page 186...
... questionnaires; (PE) physical examination; (LAB)
From page 187...
... Xb X X X X X Liver disease (lifetime history)
From page 188...
... X Stool occult blood test (LAB) X X X Protein profile: prealbumin (mg/dl)
From page 189...
... physical examination; (LAB) laboratory tests; (MRV)
From page 190...
... questionnaires; (PE) physical examination; (LAB)
From page 191...
... TABLE B-6 Cardiovascular Assessment Cycle 1 2 3 4 5 6 Examination Year 1982 1985 1987 1992 1997 2002 Analyzed Endpoints Essential hypertension (Q/MRV/PE) X X X X X Heart disease (excluding essential hypertension)
From page 192...
... questionnaires; (PE) physical examination; (LAB)
From page 193...
... X X X Absolute neutrophils (segs) (thousand/mm3)
From page 194...
... questionnaires; (PE) physical examination; (LAB)
From page 195...
... X X X Antithyroid antibodies (LAB) X X X Fasting glucose (mg/dl)
From page 196...
... X X GADA (LAB) X Total testosterone (ng/dl)
From page 197...
... questionnaires; (PE) physical examination; (LAB)
From page 198...
... (LAB) X X Absolute lymphocytes (cells/mm3)
From page 199...
... questionnaires; (PE) physical examination; (LAB)
From page 200...
... X FEV MAX (LAB) X Ratio of observed FEV1 to observed FVC (LAB)
From page 201...
... physical examination; (LAB) laboratory tests; (MRV)
From page 202...
... All X X X X X Malignant X X X X X X Benign X X X X X Uncertain behavior or unspecified nature X X X X X Cell Type-Specific Analysesa Basal cell carcinoma X X X X X X Squamous cell carcinoma X X X X X X Fibrosarcoma X Nonmelanoma X X X Melanoma X X Xb X X X Sun exposure-related malignancies X X Systemic neoplasms (MRV/ PE) Behavior (All Sites Combined)
From page 203...
... X X X X X X Urinary system Xe Xf Xf Xf X X Kidney and ureter Xe Xf Xf Xf X Prostate Xe X X X X X Penis and other male genital organs Xe X X X X X Testicles Xe X X X X X Bone and articular cartilage X X Extrahepatic bile duct X X Ill-defined sites X X X Connective and other soft tissues X X X X X Hodgkin's disease X X X X X X Non-Hodgkin's lymphoma X X X X Leukemia X X X X X Other malignant systemic neoplasms of lymphoid and histiocytic tissue X X X X X Lymphoreticular sarcoma X X Multiple myeloma X X Soft-tissue sarcoma X Premalignant Carcinoma in situ (breast, digestive organs, respiratory, prostate, penis X Xg X Xh X and other male genitals, bladder and other, and nonspecified urinary) Premalignant and Malignant Stomach (All)
From page 204...
... physical examination; (LAB) laboratory tests; (MRV)
From page 205...
... X CDC birth defect category: genital anomalies (Q/MRV) X Birth defects: urinary system anomalies (Q/MRV)
From page 206...
... 206 TABLE B-14 Laboratory Analyses Cycle 1 2 3 4 5 6 Examination Year 1982 1985 1987 1992 1997 2002 Hematology Cell Count/Indices X X X X X X WBC X X X X X X RBC X X X X X X RDW X X X X HGB X X X X X X Hematocrit X X X X X X MCV X X X X X X MCH X X X X X X MCHC X X X X X X PLT X X X X X X Differential X X X X X X Neutrophils X X X X X X LYMPH X X X X X X MONO X X X X X X EOS X X X X X X BANDS X X X X X X BASO X X X X X X BLAST X X X X X X RBC morphology X X X X X Platelet observation X X X X X Cells counted X X X X X X Absolute differential ABS SEGS X X X X X ABS BANDS X X X X X ABS LYMPHS X X X X X ABS MONOS X X X X X ABS EOS X X X X X ABS BASOS X X X X X RPR/VDRL/FTA X X X X X X ESR X X X X X X Glucose, 2HR PP X X X X X X Prothrombin time X X X X X X Chemistry Routine BUN X X X X X X Glucose fasting X X X X X X Cholesterol X X X X X X HDL cholesterol X X X X X X Triglycerides X X X X X X SGOT/AST X X X X X X SGPT/ALT X X X X X X
From page 207...
... 207 TABLE B-14 Continued Cycle 1 2 3 4 5 6 Examination Year 1982 1985 1987 1992 1997 2002 Gamma GT X X X X X X Alkaline phosphatase X X X X X X Total LDH X X X X X X Creatinine serum X X X X Creatine kinase X X X X X X Amylase X X X X X Total bilirubin X X X X X X Direct bilirubin X X X X X X Chemistry Miscellaneous FSH X X X X X X LH X X X X X X Testosterone, free X X X Testosterone, total X X X X X X Sex hormone binding globulin X Estradiol X X X T4, free X T4, RIA X X X X X T3, free X T3, uptake X X X TSH X X X X X X FTI X PSA X X X Insulin, fasting X Glucagon @ 2 hr X X Insulin, serum @ 2 hr X X X Glycated hemoglobin X X X C Peptide, serum X X ACTH, serum X Uric acid X Urinalysis Routine Color X X X X X X Character X X X X X X Glucose X X X X X X pH X X X X X X Ketone X X X X X X Protein X X X X X X Bile X X X X X X Occult blood X X Urobilinogen X X X X X X Specific gravity X X X X X X Epithelial cells X X X X X X continues
From page 208...
... 208 TABLE B-14 Continued Cycle 1 2 3 4 5 6 Examination Year 1982 1985 1987 1992 1997 2002 Urinalysis Routine (continued) Bacteria X X X X X X Mucus X X X X X X WBC/HPF X X X X X X Casts X X X X X Crystals X X X X X RBC X X X X X Nitrites X X X X X Leukocyte esterase X X Other X X X Comments X X X X X X Glucose, urine 2 hr X X X X X X Urine 24 hr Coproporphyrin X X Uroporphyrin X X Porphobilinogen X X Heptacarboxyporphyrins X Hexacarboxyporphyrins X Pentacarboxyporphyrins X Creatinine X Aminolevulinic Acid X Comments X X Cortisol Differential Cortisol 1 X X Cortisol 2 X X Protein Electrophoresis Total protein X X X Prealbumin X X X Albumin X X X X X X Alpha 1 globulin X X X X X X Alpha 2 globulin X X X X X X Beta globulin X X X X X X Gamma globulin X X X X X X IGA X X X X X X IGG X X X X X X IGM X X X X X X Protein Profile Alpha 1 acid glycoprotein X X X X Alpha 1 antitrypsin X X X X
From page 209...
... 209 TABLE B-14 Continued Cycle 1 2 3 4 5 6 Examination Year 1982 1985 1987 1992 1997 2002 Alpha 2 macroglobulin X X X X Apolipoprotein B X X X X C3 complement X X X X C4 complement X X X X Haptoglobin X X X X Transferrin X X X X HI-RES Electrophoresis High-resolution bands IGG-Kappa X IGG-Lambda X IGG-No light chain X IGA-Kappa X IGA-Lambda X IGA-No light chain X IGM-Kappa X IGM-Lambda X IGM-No light chain X KAPPA-No heavy chain X LAMBDA-No heavy chain X Hepatitis Panel HA Antibody X X X X X HBs Antigen X X X X X X HBc Antibody X X X X X HBs Antibody X X X X X X HC Antibody X X X HD Antibody X X HIV-1 ELISA Screen X X X X Semen Analysis Total count X Volume X Abnormal forms X Immunology Mixed lymphocyte RX X X Cell surface markers X X Killer cell no interferon X X Killer cell interferon X X Mitogen PHA stimulate X X Mitogen pokweed stimulation X X continues
From page 210...
... /CD3 X (CD3 + CD20 + CD16) /CD45 X Occult Blood Panel -- Fecal Occult blood 1 X Occult blood 2 X Occult blood 3 X
From page 211...
... 211 TABLE B-14 Continued Cycle 1 2 3 4 5 6 Examination Year 1982 1985 1987 1992 1997 2002 Mouse Stomach/Kidney Lupus Panel Antinuclear AB X X Antimitochondrial AB X X X Antismooth Muscle AB X X X Antiparietal Cell AB X X X MSK other X Thyroid microsomal AB X X X Rheumatoid factor latex X X X ANA on HEP-2 Cells Hep-2 cells X Speckled X Homogenous X Nucleolar X Centromere X ANA Hep-2 other X DNA antibodies (IFA) X Anti Sm X Anti RNP X SSA antibody X SSB antibody X Lymphocyte phenotyping panel X X X Islet cell antibody X X X T-Cell clone X Anti-thyroid antibody X X Fibrinogen X X Microalbumin Microalbumin screen X Urine creatinine X Microalbumin quantity X Ratio X Diabetes Panel Hemoglobin A1c X Islet Cell AB X GAD Ab X C-Peptide X Proinsulin X
From page 212...
... physical examination; (LAB) laboratory tests; (MRV)
From page 213...
... vascular insufficiency history Demographic Normal physical activity level Employment history Dietary surveyb Marital/reproductive history 5 Subject Medical history Percentage of herbicide spraying Substance abuse history missions flown Leisure activities Intentional herbicide ingestion Mortality data 6 Subject Drinking history 2 weeks prior to Additions to Interval Questionnaires physical exam 2 Subject Current personal relationships Skin cancer Employment history 1 week prior Personality type to physical exam Birth marks Children under 18 living at home Smoking habits (including children, Drinking habits grandchildren, stepchildren, 3 Subject foster or adopted children) Detailed drinking history History of mission volunteerism Sleep disorders in SEA Interviewer remarks section addeda aThis section was added to the baseline questionnaire.
From page 214...
... Reproductive Outcomes. Brooks AFB, TX: Armstrong Laboratory.


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