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Appendix C Epidemiological Studies of Vietnam Veterans Health
Pages 215-238

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From page 215...
... C Epidemiologic Studies of Vietnam Veterans Health Table C-1 provides an overview of design aspects of the epidemiologic studies related to Vietnam veterans' health reviewed in the Institute of Medicine's Veterans and Agent Orange report series (IOM, 1994, 1996, 1999, 2001, 2003, 2005)
From page 216...
... TABLE C-1 Epidemiologic Studies of Vietnam Veterans 216 Study Study Group Comparison Reference Design Description (N) Group (N)
From page 217...
... Michalek Cohort Based on physical examination through 1992 and medical records reviewed through 1,109 Ranch Hands 1,493 Ranch Hand et al., 2001a March 1993, association between serum dioxin levels and hepatic abnormality comparisons Michalek Cohort Based on physical examination in 1982, 1985, 1987, 1992, and 1997, and medical 761 Ranch Hands 1,086 Ranch Hand et al., 2001b records through 1997, association between serum dioxin and peripheral neuropathy comparisons Michalek Cohort Based on physical examination in 1982, 1985, 1987, and 1992, and medical records 953 Ranch Hands 1,280 Ranch Hand et al., 2001c through 1997, association between serum dioxin and hematologic function comparisons Steenland Cohort Reexamine and compare diabetes data from the NIOSH cohort and the United 267 NIOSH 227 NIOSH et al., 2001 States Air Force (USAF) Ranch Hands in order to reconcile differences between workers; comparisons the two study methods and protocols 990 Ranch Hands 1,275 Ranch Hand comparisons AFHS Studies Reviewed in Update 2000 AFHS, 2000 Cohort 266 health-related endpoints, including assessments of 10 clinical areas: general 995 1,299 health, neoplasia, neurologic, psychologic, gastrointestinal, cardiovascular, hematologic, endocrine, immunologic, pulmonary Longnecker Cohort Based on physical examination and medical records review through 1992, -- 1,197 and Michalek, association between serum dioxin and diabetes mellitus among comparison group 2000 (no Ranch Hands)
From page 218...
... TABLE C-1 Continued 218 Study Study Group Comparison Reference Design Description (N) Group (N)
From page 219...
... Henriksen Cohort Relationship between serum dioxin and glucose, insulin, and diabetes mellitus in 989 1,276 et al., 1997 Ranch Hands through 1992 AFHS, 1996; Cohort Mortality update, Ranch Hands through the end of 1993 in the AFHS cohort (1983, 1,261 19,080 Michalek 1984b, 1985, 1986, 1989, 1991a, 1995) et al., 1998b Henriksen Cohort Serum dioxin and reproductive hormones in Ranch Hands, 1982, 1985, 1987, and 1,045 1,224 participants et al., 1996 1992 participants (1982)
From page 220...
... cohort) 1986, 1989, spray herbicides 1991a Michalek Cohort Mortality of Ranch Hands, compared with USAF C-130 air and ground crew 1,261 19,101 et al., 1990 veterans in Southeast Asia Wolfe et al., Cohort Health status of Ranch Hands at second follow-up, compared with USAF C-130 995 1,299 1990 air and ground crew veterans in Southeast Asia Centers for Disease Control and Prevention Studies Reviewed in VAO Decoufle Cohort Association between self-reported health outcomes and perception of exposure to 7,924 7,364 et al., 1992 herbicides based on Vietnam Experience Study O'Brien et al., Cohort Interview report and mortality for NHL based on Vietnam Experience Study 8,170 7,564 1991 CDC, 1990a Case- Selected Cancers Study: population-based case-control study of all men born 1,157 NHL; 1,776 control 1921–1953; cases diagnosed area covered by eight cancer registries, controls 342 STS; selected by random-digit dialing 310 HD; 48 nasal carcinoma; 80 nasopharyngeal carcinoma; 130 primary liver cancer
From page 221...
... CDC, 1990b Case- Selected Cancers Study: population-based case-control study of all men born 1,157 1,776 control 1921–1953; cases diagnosed in area covered by eight cancer registries, controls selected by random-digit dialing for NHL CDC, 1990c Case- Selected Cancers Study: STS 342 1,776 control CDC, 1990d Case- Selected Cancers Study: HD, nasal cancer, nasopharyngeal cancer, primary liver 310 HD; 48 nasal 1,776 control cancer carcinoma; 80 nasopharyngeal carcinoma; 130 primary liver cancer CDC, 1989b Cohort Vietnam Experience Study: random sample, U.S. Army enlisted men, 1965–1971 2,490 1,972 CDC, 1988a Cohort Vietnam Experience Study: random sample, U.S.
From page 222...
... TABLE C-1 Continued 222 Study Study Group Comparison Reference Design Description (N) Group (N)
From page 223...
... Dalager et al., Case- HD cases diagnosed 1969–1985 among Vietnam-era veterans 283 404 1995b control Watanabe and Cohort Postservice mortality among Marine Vietnam veterans 10,716 9,346 Kang, 1995 Department of Veterans Affairs Studies Reviewed in Update 1996 Dalager et al., Cohort Update of Thomas et al.
From page 224...
... TABLE C-1 Continued 224 Study Study Group Comparison Reference Design Description (N) Group (N)
From page 225...
... Kang et al., Case- STS cases (1975–1980) diagnosed at the Armed Forces Institute of Pathology 217 599 1987 control (AFIP)
From page 226...
... among Vietnam veterans, 214 727 1991 control compared with Massachusetts Vietnam-era veterans with cancers of other sites Deprez et al., Descriptive Maine: Vietnam veterans, compared with atomic test veterans and general 249 113 atomic test 1991 population, for health status and reproductive outcomes veterans Levy, 1988 Cross- Massachusetts: PTSD in chloracne as indicator of exposure to TCDD; control 6 25 sectional Vietnam veterans Anderson Cohort Wisconsin: mortality experience, veterans compared with nonveterans (Phase 1) ; 110,815 white 342,654 white et al., 1986a mortality experience of Vietnam veterans and Vietnam-era veterans, compared with male veteran male non-veteran nonveterans and other veterans (Phase 2)
From page 227...
... Anderson Cohort Wisconsin: mortality experience in Vietnam-era veterans and Vietnam veterans, 122,238 Vietnam- -- et al., 1986b compared with U.S. men, Wisconsin men, Wisconsin nonveterans, and Wisconsin era veterans; other veterans 43,398 Vietnam veterans Goun and Case- Pennsylvania: STS, NHL, selected rare cancer cases, compared with controls 349 349 deceased Kuller, 1986 control without cancer for Vietnam experience in men (1968–1983)
From page 228...
... TABLE C-1 Continued 228 Study Study Group Comparison Reference Design Description (N) Group (N)
From page 229...
... of Australian veterans who served in Vietnam 59,036 men -- 1997a 484 women Crane et al., Cohort Mortality experience (through 1994) of Australian national servicemen who served 18,949 24,646 1997b in Vietnam O'Toole et al., Cross- Survey of self-reported health status (1989–1990)
From page 230...
... TABLE C-1 Continued 230 Study Study Group Comparison Reference Design Description (N) Group (N)
From page 231...
... Other Vietnam Veterans Studies Reviewed in Update 1998 Chinh et al., Cohort Antinuclear antibodies and sperm autoantibodies among Vietnamese veterans who 25 63; 1996 served 5–10 years in a "dioxin-sprayed zone" 36 NOTE: Abbreviations: 2,4,5-T, 2,4,5-trichlorophenoxyacetic acid; AFHS, Air Force Health Study; CDC, Centers for Disease Control and Prevention; CDVA, Commonwealth Department of Veterans' Affairs (Australia) ; HD, Hodgkin's disease; MVA, motor vehicle accidents; NIOSH, National Institute for Occupational Safety and Health; NHL, non-Hodgkin's lymphoma; NMES, National Medical Expenditure Survey; PTSD, post-traumatic stress disorder; SMR, standardized mortality ratio; STS, soft-tissue sarcoma; TCDD, 2,3,7,8-tetrachlorodibenzo-p-dioxin; Update 2004, Veterans and Agent Orange: Update 2004 (IOM, 2005)
From page 232...
... 232 DISPOSITION OF THE AIR FORCE HEALTH STUDY REFERENCES AFHS (Air Force Health Study)
From page 233...
... 1988a. Health status of Vietnam veterans.
From page 234...
... 1992. Self-reported health status of Vietnam veter ans in relation to perceived exposure to herbicides and combat.
From page 235...
... APPENDIX C 235 Fiedler N, Gochfeld M
From page 236...
... 2001. US Army Chemical Corps Vietnam veterans health study: preliminary results.
From page 237...
... 1996a. The Australian Vietnam Veterans Health Study: I
From page 238...
... 1990. Health status of Air Force veterans occupationally ex posed to herbicides in Vietnam.


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