Proceedings from the Workshop on Biomedical Materials at the Edge Challenges in the Convergence of Technologies (2006) / Chapter Skim
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Abstract: Stem Cells as Biomaterials of the Future
Abstract: Stem Cells as Biomaterials of the Future
Pages 18-20
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From page 18... ...
Although the public controversy surrounding the use of hESCs arises primarily from the technique required to harvest these cells -- destruction of the human embryo -- logistical, technical, and legislative hurdles to the use of hESCs also exist. In this overview presentation, issues surrounding basic cell culture techniques, implantation safety, funding sources, legislation, stem cell sources, and transplantation are discussed.
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From page 19... ...
In experiments involving transplantation into the uninjured hearts of athymic rats, researchers found that hESC-derived cardiomyocytes indeed formed substantial, highly proliferative, and, at least at later time points, exclusively cardiac grafts within the rat heart. While ongoing studies have demonstrated the successful formation of similar human cardiac implants within experimentally infarcted hearts, this preclinical work has also highlighted important but perhaps surmountable challenges for such cell-based 19
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From page 20... ...
Over the past several years, Osiris Therapeutics has evaluated the ability of MSCs to engraft in recipients without immunological matching. This use of allogeneic stem cells for tissue repair in unrelated recipients has exciting implications for the ready availability of adult stem cell therapies in the clinic.
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