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6 Description of Epidemiologic Studies Included in Evidentiary Dataset
Pages 104-158

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From page 104... ... of each studied population on a citation-specific basis; boldface indicates particular citations that were the source of evidence abstracted for any of the cancer sites under consideration. Table 6.2 presents results observed in the informative cohort populations with regard to the recognized asbestos-related health effects: asbestosis, mesothelioma, and lung cancer. Read the entire page →
From page 106... ... 106 to al. Read the entire page →
From page 111... ... no but 140-149 140-149 given and and repair, Exposure with male observed construction plumbers' Sweden- union Canada -- of workers Italy -- railway- construction and workers Asbestos Italy -- ship number = clear. # Occupations Ontario, members pipefitters' Finland -- 7,775 shipyard Tuscany, carriage repair Genoa, refitting, Gothenburg, shipyard Other Substantial 36. Read the entire page →
From page 113... ... 113 al. Read the entire page →
From page 114... ... Textile and Population 1,229 Cement cement cement Italy -- 889 female Rochdale, England Charleston, black and asbestos Denmark -- Danish Ltd. Emilia 10 Casale asbestos TABLE Cohort number, Asbestos 15. Read the entire page →
From page 117... ... 46.6 18, and and repair, Exposure with male construction plumbers' Sweden- union Canada -- of workers Italy -- railway construction and workers Asbestos Italy -- ship Occupations Ontario, members pipefitters' Finland -- 7,775 shipyard Tuscany, carriage repair Genoa, refitting, Gothenburg, shipyard Other Substantial 36. Read the entire page →
From page 118... ... The considerably greater number of cohorts in the uninformative category gives an indication of the extent to which research has focused on reporting respiratory outcomes of asbestos exposure. The cohort studies retained for the evidentiary dataset addressed defined occupational cohorts in specific asbestos industries (such as mining and milling, cement, textile, and friction products) Read the entire page →
From page 119... ... * Percent Cohort Population Time Elapsed to Final Follow-up Original (location � number, description) Read the entire page →
From page 120... ... (+ marks earliest exposure, if known) Cohort Dead Asbestos Textile Workers 15. Read the entire page →
From page 121... ... England and Wales, UK � national -- -- -- 4% survey of 31,150 male asbestos workers 35. USA � 1,074 white male asbestos -- -- -- -- -- -- -- -- -- -- 88% industry retirees Other Occupations with Substantial Asbestos Exposure 36. Read the entire page →
From page 122... ... * Percent Cohort Population Time Elapsed to Final Follow-up Original (location � number, description) Read the entire page →
From page 123... ... Denmark � 953 male insulation workers -- (Petersen and Venstrup-Nielsen 1982) Asbestos Textile Workers London, UK � 379 male asbestos-textile -- -- -- -- -- -- -- -- -- -- factory workers (Berry et al. Read the entire page →
From page 124... ... al 1979) South Africa � miners and asbestos cement workers (Goldstein et al. Read the entire page →
From page 125... ... (+ marks earliest exposure, if known) Cohort Dead Other Occupations with Substantial Asbestos Exposure Poland � 1,190 female asbestos producing -- -- -- -- -- -- -- -- -- - 11% plant workers (Szeszenia-Dabrowska et al. Read the entire page →
From page 126... ... * Percent Cohort Population Time Elapsed to Final Follow-up Original (location � number, description) Read the entire page →
From page 127... ... * Percent Cohort Population Time Elapsed to Final Follow-up Original (location � number, description) Read the entire page →
From page 128... ... Although under-ascertainment would tend to diminish the power of these studies, it is unlikely to have created an important systematic bias because it is reasonable to assume that the extent of disease ascertainment was unrelated to asbestos exposure. Cancer mortality information in the cohort studies was derived predominantly from death certificates. Read the entire page →
From page 129... ... None of the cohort studies included data on histologic type of cancer; although many of the 36 case-control studies (discussed in the following section) involved histologic confirmation of cancer diagnosis, their results were not generally presented by histologic type. Read the entire page →
From page 130... ... 130 since since highest digestive highest highest yrs + yrs (1) 20 employed 30-34 tract 150-159; 150-159 151-154; 150-154; exposure exposure peritoneum Comments ICD8 exposed: first ICD9 + ICD8 exposed: 1935-36 ICD? Read the entire page →
From page 131... ... 131 yrs 10 since continues highest highest highest yrs mppcfy mppcfy mppcfy 80 80 80 20 exposed: 150-159 150-159; 150-159; 150-159; exposure ICD8 ICD? exposed: ICD? Read the entire page →
From page 132... ... 132 group yr data 20 cohort multiple cotton-mill for exposure; years, exposure: 150-159; employed comparison first 150-159; yr 15-64 Comments ICD9 presented since highest 20 ICD7 age companies; worker p-value) Exposed 0.92 CI) Read the entire page →
From page 133... ... 133 + cancer particles highest exposed, exposure results stomach yr first + rectum; 15 millions pancreatic + since = 150-159 6.0) yr for Esophagus colon exposed: 30 ICD8 SIRs (10.0, mppcfy Diseases; ratio. Read the entire page →
From page 135... ... ? M X X X X XX mainly XX X XX X XX XX XX mainly XX mainly of female factories and asbestos workers 700 cement asbestosis parts factories survey two plant and Construction for at textile plumbers' of cement cement male retirees automotive UK -- TAC Italy -- asbestos UK -- national compensated Italy -- 10 US -- workers workers US -- asbestos industry UK -- 3,000 LA, SC, Wales, union England, Ltd. Read the entire page →
From page 139... ... There were too few studies of single forms of asbestos to support separate evaluations according to fiber type and inclusion of studies with exposure to mixed or unknown fiber types would have generated fiber-type-specific associations subject to considerable uncertainty; consequently the committee did not characterize associations by fiber type. The type and quantity of data available for assessing asbestos exposures varied considerably among studies. Read the entire page →
From page 140... ... . CASE-CONTROL STUDIES Reports Included in the Evaluation of Cancer Risks The committee's search for relevant case-control studies first screened the literature for investigations of the selected cancers that included occupation among the risk factors considered and then retained those that actually assessed and reported asbestos exposure. Read the entire page →
From page 141... ... DESCRIPTION OF EPIDEMIOLOGIC STUDIES 141 TABLE 6.5 Summary of Case-Control Studies Addressing Selected Cancers Type of Cancer Investigated Quality of Exposure Characterization Pharyngeal Laryngeal Esophageal Stomach Colorectal High 11 unique Berrino Berrino citations et al. Read the entire page →
From page 142... ... This characteristic applies to laryngeal, pharyngeal, esophageal, and stomach cancers. Finally, case-control studies are well suited to exposures that cause disease only after a long latent period, as is presumed to occur between asbestos exposure and cancer. Read the entire page →
From page 143... ... Health Outcome Data Case-control studies examine the association between asbestos and cancer by identifying people with cancer (cases) and comparing their asbestos exposure with that of people without cancer (controls) Read the entire page →
From page 144... ... created specifically to look at asbestos exposure. Those methods avoid some of the limitations of recall bias because exposure is not directly self-assessed, and they greatly improve the quality of the assessment. Read the entire page →
From page 145... ... British Journal of Industrial Medicine 42(4) Read the entire page →
From page 146... ... British Journal of Industrial Medicine 37(2) Read the entire page →
From page 147... ... British Journal of Industrial Medicine 46(10) Read the entire page →
From page 148... ... 1977. Insulation workers in Belfast: A further study of mortality due to asbestos exposure (1940-75) Read the entire page →
From page 149... ... 1994. Mortality study of asbestos cement workers. Read the entire page →
From page 150... ... British Journal Industrial Medicine 48(4) Read the entire page →
From page 151... ... British Journal of Industrial Medicine 25(4) Read the entire page →
From page 152... ... British Journal of Industrial Medicine 50(9) Read the entire page →
From page 153... ... A co hort study in the asbestos cement industry. British Journal of Industrial Medicine 47(9) Read the entire page →
From page 154... ... British Journal of Industrial Medicine 42(6) Read the entire page →
From page 155... ... British Journal of Industrial Medicine 36(3) Read the entire page →
From page 156... ... 1992. The risk of lung cancer and mesothe lioma after cessation of asbestos exposure: A prospective cohort study of shipyard work ers. Read the entire page →
From page 157... ... British Journal of Industrial Medicine 45(4) Read the entire page →
From page 158... ... National Sheet Metal Examination Group. American Journal of Industrial Medicine 25(5) Read the entire page →

From page 104...

... of each studied population on a citation-specific basis; boldface indicates particular citations that were the source of evidence abstracted for any of the cancer sites under consideration. Table 6.2 presents results observed in the informative cohort populations with regard to the recognized asbestos-related health effects: asbestosis, mesothelioma, and lung cancer.

6 Description of Epidemiologic Studies Included in Evidentiary Dataset Pages 104-158

6 Description of Epidemiologic Studies Included in Evidentiary Dataset
Pages 104-158