Health Risks from Dioxin and Related Compounds Evaluation of the EPA Reassessment (2006) / Chapter Skim
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Appendix B EPA's 2005 Guidelines for Carcinogen Risk Assessment
Appendix B EPA's 2005 Guidelines for Carcinogen Risk Assessment
Pages 236-240
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From page 236... ...
B EPA's 2005 Guidelines for Carcinogen Risk Assessment "CARCINOGENIC TO HUMANS" This descriptor indicates strong evidence of human carcinogenicity. It covers different combinations of evidence.
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From page 237... ...
APPENDIX B 237 "LIKELY TO BE CARCINOGENIC TO HUMANS" This descriptor is appropriate when the weight of the evidence is adequate to demonstrate carcinogenic potential to humans but does not reach the weight of evidence for the descriptor "Carcinogenic to Humans." Adequate evidence consistent with this descriptor covers a broad spectrum. As stated previously, the use of the term "likely" as a weight of evidence descriptor does not correspond to a quantifiable probability.
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From page 238... ...
238 APPENDIX B species. Depending on the extent of the database, additional studies may or may not provide further insights.
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From page 239... ...
APPENDIX B 239 "NOT LIKELY TO BE CARCINOGENIC TO HUMANS" This descriptor is appropriate when the available data are considered robust for deciding that there is no basis for human hazard concern. In some instances, there can be positive results in experimental animals when there is strong, consistent evidence that each mode of action in experimental animals does not operate in humans.
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