Skip to main content

Assessing the Human Health Risks of Trichloroethylene Key Scientific Issues (2006) / Chapter Skim
Currently Skimming:

8 Immunotoxicity
Pages 246-252

The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
Select key terms on the right to highlight them within pages of the chapter.


From page 246...
... 8 Immunotoxicity This chapter reviews information about the effects of trichloroethylene on the immune system, particularly information generated since the U.S. Environmental Protection Agency released its draft health risk assessment (EPA 2001b)
Read the entire page →
From page 247...
... resulted in suppression of humoral and cell-mediated immunity in female CD1 mice. Bone marrow stem cell activity was depressed at drinking water concentrations of 0.1-1 mg/mL.
Read the entire page →
From page 248...
... However a 90-day exposure to trichloroethylene at 0.07 and 0.7 mg/mL in drinking water produced a significant decrease in humoral immunity in female, but not male, mice.
Read the entire page →
From page 249...
... Theoretically, trichloroethylene metabolites may be increased with enhancers of the CYP2E1 gene, and autoimmunity in MRL mice induced by trichloroethylene has been shown to be inhibited with CYP2E1 inhibitors (Griffin et al.
Read the entire page →
From page 250...
... (1988) reported on a human leukemia cluster putatively exposed to high concentrations of trichloroethylene and other solvents via contaminated drinking water.
Read the entire page →
From page 251...
... Pharmacokinetic modeling of specific metabolites of trichloroethylene is important to consider and apply to specific mechanisms that may be responsible for immunotoxicity. Little is known about the genes that determine susceptibility to autoimmune and other immune diseases in humans.
Read the entire page →
From page 252...
... 22 ASSESSING THE HUMAN HEALTH RISKS OF TRICHLOROETHYLENE may be due to metabolism of trichloroethylene to chloral, which is a biologically plausible mechanism for humans. Recommendations: More animal research is needed to clarify the metabolites and modes of action responsible for trichloroethylene-induced auto immunity and immunosuppression.
Read the entire page →

Key Terms

  • pharmacokinetic model
  • trichloroethylene exposure
  • drinking water
  • trichloroethylene metabolites
  • trichloroethylene metabolite

  • trichloroethylene metabolism
  • trichloroethylene causes
  • chloral hydrate
  • specific metabolites
  • pharmacokinetic modeling


    • This material may be derived from roughly machine-read images, and so is provided only to facilitate research.
    More information on Chapter Skim is available.