Dietary Reference Intakes Research Synthesis Workshop Summary (2007) / Chapter Skim
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12 New and Underutilized Research Techniques and the Dietary Reference Intakes
12 New and Underutilized Research Techniques and the Dietary Reference Intakes
Pages 151-164
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Rosenberg of Tufts University, who served as a member of the Subcommittee on Upper Reference Levels of Nutrients, addressed promising research techniques and a research strategy for setting Tolerable Upper Intake Levels (ULs)
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at the cytosine position can have a substantial influence on gene expression and that dietary methyl donors can influence the level of methylation to some extent. This is a knowledge area that is important to understand, particularly when it is possible that one can influence not only gene expression but even the total silencing of a gene, resulting in genetic imprinting and some very important phenotypic outcomes.
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The intent of this model is to illustrate that when new data are obtained, models will be needed to help interpret how findings about requirements of subpopulations should influence requirements set for the overall population.
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represents the entire population FIGURE 12-2 A possible model of the MTHFR variant related to the folate requirement. NOTE: Dashed line (ala/ala)
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Research Strategy for Setting ULs The report of the Upper Levels Subcommittee (IOM, 1998b) did not contain a set of research recommendations, in spite of the fact that the research needs were very great.
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Progress in this area will require a commitment to the research that allows making good judgments. A FOCUS ON PROTEIN AND AMINO ACIDS Presenter: Paul B
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Methods for determining amino acid requirements include growth, which is useful only during rapid growth; nitrogen balance; direct oxida
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comparing a commercially available parenteral amino acid solution to a new parenteral solution, and (2) identifying limiting amino acids in both parenteral solutions.
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. Transcriptomics is used to analyze gene expression (what appears to be happening)
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With regard to research recommendation 266-E, genetics might be used, for example, to predict who is going to benefit from the classical approaches to successful or lasting weight loss. Figure 12-4 shows a 12month follow-up of obese subjects who were placed on hypocaloric diets (Corella et al., 2005)
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model (Brindle et al., 2002) is a noninvasive, multivariate statistical approach to predicting coronary artery status that makes catheterization (a very invasive process)
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Because of the huge amount of information that is being generated by these new techniques, it is important to use bioinformatics to process the information and make it readily usable. By using this approach and the different connections between genes and gene products, it will be possible to define, for example, the mechanisms by which arachidonic acid and docahexaenoic acid (DHA)
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163 NEW AND UNDERUTILIZED RESEARCH TECHNIQUES possible to increase the points at which specific nutrients can be targeted for disease prevention and even treatment. Concluding Remarks Dr.
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