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Appendix 5 HFE-7100: Methyl Nonafluorobutyl Ether (40%) (CAS Reg. No. 163702-07-6) plus Methyl Nonafluoroisobutyl Ether (60%) (CAS Reg. No. 163702-08-7) Acute Exposure Guideline Levels
Pages 193-227

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From page 193...
... 163702-08-7) 1 Acute Exposure Guideline Levels SUMMARY Hydrofluoroether-7100 (HFE-7100)
From page 194...
... 194 Acute Exposure Guideline Levels agent, specialty solvent, and heat transfer medium. It is a volatile liquid with a slight ethereal odor.
From page 195...
... Hydrofluoroether-7100 195 al.
From page 196...
... 196 Acute Exposure Guideline Levels of adrenaline during a second 5-min exposure exhibited severe clinical signs including whole-body tremors. Although the 89,300 ppm exposure for 5 min was a clear NOAEL for death, the challenge dose of epinephrine to the second dog (during continuing exposure)
From page 197...
... Hydrofluoroether-7100 197 TABLE 5-1 Summary of AEGL Values for HFE-7100 Classifica- End point tion 10 min 30 min 1h 4h 8h (Reference) AEGL–1 2,500 2,500 2,500 2,500 2,500 Reversible (Nondis- ppm ppm ppm ppm ppm organ abling)
From page 198...
... 198 Acute Exposure Guideline Levels HFE-7100 is a highly volatile liquid with a slight ethereal odor. No information on the odor threshold was located.
From page 199...
... TABLE 5-2 Chemical and Physical Data Parameter Value Reference Synonyms Methyl nonafluorobutyl ether: 3M Company 2000 1-methoxy-1,1,2,2,3,3,4,4,4-nonafluorobutane; 1-methoxyperfluorobutane; 1,1,1,2,2,3,3,4,4-nonafluoro 4-methoxybutane Methyl nonafluoroisobutyl ether: 1-methoxy-2-trifluoromethyl-1,1,2,3,3,3 hexafluoropropane; 1-methoxyperfluoroisobutane; 2 (difluoromethoxymethyl) -1,1,1,2,3,3,3 heptafluoropropane Chemical formula AIHA 1999; C5H3F9O Methyl nonafluorobutyl ether: Coombs et al.
From page 200...
... 200 TABLE 5-2 Continued Parameter Value Reference Physical state Clear, colorless liquid 3M Company 2000 Solubility in water <12 ppm 3M Company 2000 Oil/gas partition coefficient 9.66 Eger et al. 1999 Saline/gas partition coefficient 0.0050 Eger et al.
From page 201...
... Hydrofluoroether-7100 201 2.6. Summary HFE-7100 is a newly developed ether with a slight ethereal odor that is intended for use as a cleaning agent and speciality solvent.
From page 202...
... Only one study with acute exposure was located. Additional studies with repeated and subchronic exposures are included in the following discussion.
From page 203...
... Hydrofluoroether-7100 203 sluggish approximately 30 min into the exposure. At 3 h into the exposure, respirations ranged from 60-80/min which was described as slightly depressed.
From page 204...
... 204 Acute Exposure Guideline Levels formed, major organs were weighed, and tissues and organs were examined microscopically. There were no treatment-related clinical signs or effects on body weight, food consumption, or hematology, clinical chemistry, or urine parameters (with the exception of a dose-related increase in urinary fluoride excretion)
From page 205...
... Hydrofluoroether-7100 205 10 female Sprague-Dawley rats to measured concentrations of 1,502, 4,550, 7,533, or 15,159 ppm for 6 h/day, 5 days/week, for 13 weeks (Coombs et al.
From page 206...
... 206 Acute Exposure Guideline Levels TABLE 5-3 Response of Dogs during a Cardiac Sensitization Testa,b,c Concentration (ppm) Response 10,000 Struggling and slight salivation (1 dog)
From page 207...
... Hydrofluoroether-7100 207 were conducted. This study was used to set exposure concentrations for further studies.
From page 208...
... 208 Acute Exposure Guideline Levels group was two fetuses in two litters with one extra thoracolumbar vertebra. In the 7,538 ppm group, a single fetus was observed with a complete lumbar rib.
From page 209...
... Hydrofluoroether-7100 209 3.8. Summary The animal inhalation data involving HFE-7100 are summarized in Table 5-4.
From page 210...
... TABLE 5-4 Summary of Animal Toxicity Data for HFE-7100 210 Exposure Species Concentration (ppm) Duration (number)
From page 211...
... effects; not neurotoxic 15,159 13 weeks: Rat (groups of 20) No clinical signs at any Coombs et al.
From page 212...
... 212 Acute Exposure Guideline Levels tion and reduced body weight. Thus, the increased incidence of supernumerary ribs in the treated rats is of questionable biological significance.
From page 213...
... Hydrofluoroether-7100 213 4.2. Mechanism of Toxicity No information on the mechanism of toxicity was located.
From page 214...
... 214 Acute Exposure Guideline Levels trast to HFE-7100, both of these chemicals exhibit anesthetic properties. Although HFE-7100 is an ether, the perfluoro group limits its solubility in biological fluids.
From page 215...
... Hydrofluoroether-7100 215 can be used without time extrapolation to set a 1-h EEGL." The rapid attainment of equilibrium in the blood reasonably holds true for halogenated hydrocarbons that are not cardiac sensitizers.
From page 216...
... 216 Acute Exposure Guideline Levels mates (based on the higher respiratory rate and cardiac output of rodents compared with primates, equilibrium would be reached more rapidly in rodents) , an interspecies uncertainty factor of 1 was applied.
From page 217...
... Hydrofluoroether-7100 217 ppm for 10 min. No clinical signs were described during the 5-min exposure prior to the second challenge dose of epinephrine.
From page 218...
... 218 Acute Exposure Guideline Levels not greatly increase as exposure duration is increased (NRC 1996)
From page 219...
... Hydrofluoroether-7100 219 7.3. Derivation of AEGL-3 Taken together, the animal data indicate that the threshold for lethality in both the rat and dog lies above 89,300 ppm.
From page 220...
... 220 Acute Exposure Guideline Levels These are the two primary determinants of systemic uptake of volatile chemicals. Therefore, at similar concentrations, rodents will absorb substantially more of a chemical than primates.
From page 221...
... Hydrofluoroether-7100 221 AEGL-2 8,200 8,200 8,200 8,200 8,200 (Disabling) AEGL-3 15,000 15,000 15,000 15,000 15,000 (Lethal)
From page 222...
... 222 Acute Exposure Guideline Levels Eger, E.I., II.
From page 223...
... 2002. Acute Exposure Guideline Levels for Selected Airborne Chemicals, Vol.
From page 224...
... 224 Acute Exposure Guideline Levels APPENDIX A ACUTE EXPOSURE GUIDELINE LEVELS FOR HFE-7100 (CAS Reg.
From page 225...
... Hydrofluoroether-7100 225 Data Adequacy: Well conducted repeat dose, subchronic, developmental/reproductive, neurotoxicity, and cardiac sensitization studies, but minimal human data and limited number of animals in several studies. AEGL-2 VALUES 10 min 30 min 1h 4h 8h 8,200 ppm 8,200 ppm 8,200 ppm 8,200 ppm 8,200 ppm Key Reference: Kenny, T.J., C.K.
From page 226...
... 226 Acute Exposure Guideline Levels AEGL-2 VALUES Continued Uncertainty Factors/Rationale: Total uncertainty factor: 3 Interspecies: 1, both beagles and rats have higher respiratory rates and cardiac output than humans. Intraspecies: 3, no significant toxicological end points identified in other studies; poor solubility in biological fluids for all species.
From page 227...
... Hydrofluoroether-7100 227 3M Company 1995. 100,000 ppm for 4 h: no deaths.


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