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Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research Workshop Report (2007) / Chapter Skim
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1 Introduction
Pages 7-12

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From page 7...
... Because of this potential, in 2004 California voters approved Proposition 71 to set up a 10-year, $3 billion program to fund research on stem cells. Under the direction of the California Institute for Regenerative Medicine, this program will pay to build facilities for stem cell research and will fund doctors and scientists to carry out research with the ultimate goal of helping to develop therapies based on stem cells.
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From page 8...
... With this in mind, in 2006 the California Institute for Regenerative Medicine contracted with the National Academies to organize a workshop that would bring together experts from various areas to speak about the potential risks of oocyte donation and to summarize what is known and what needs to be known about this topic. The Committee on Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research was formed to plan the workshop, which was held in San Francisco on September 28, 2006.
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From page 9...
... from the person donating the somatic cell and none from the egg donor. This technique may one day make it possible to grow tissues that are genetically nearly identical to a donor -- allowing doctors, for example, to create replacement organs that would not be rejected by a patient's body -- but at this point no one has succeeded in making somatic cell nuclear transfer work with human oocytes.
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From page 10...
... So research on human embryonic stem cells may eventually demand a supply of eggs that are donated by women for research purposes. EGG DONATION Over the past two decades, millions of women have had oocytes collected for the purpose of assisted reproduction.
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From page 11...
... The third set of potential risks is psychological in nature and includes anxiety, mood swings, and postdonation adjustment. BOX 1-1 Potential Risks of Oocyte Donation Acute Risks Ovarian hyperstimulation syndrome Surgical Anesthetic Psychological Long-Term Risks Breast, ovarian, and endometrial cancers Future fertility
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From page 12...
... Dr. Giudice summarized the issues before the committee as "what is known, what needs to be known, and what can be done to reduce the potential risks over time." The panelists' answers to those questions are described in the pages that follow.
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Key Terms

  • embryonic stem
  • stem cell
  • somatic cell
  • cell research
  • human embryonic

  • oocyte donation
  • inner cell
  • cell mass
  • nuclear transfer
  • adult stem

  • cell nuclear
  • potential risks
  • regenerative medicine
  • assisted reproduction
  • cells stem

  • cell lines
  • cell contains
  • cell culture
  • cell structure
  • including embryonic

  • human oocyte
  • anesthetic psychological
  • hyperstimulation syndrome
  • acute risks
  • genetically nearly

  • developing human
  • spinal cord
  • medical risks
  • human embryos
  • egg donor


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