Recognition and Alleviation of Distress in Laboratory Animals (2008) / Chapter Skim
Currently Skimming:
5 Topics for Further Investigation and Recommendations
5 Topics for Further Investigation and Recommendations
Pages 87-94
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From page 87... ...
Interdisciplinary projects and translational research foci in particular offer many avenues to explore toward identifying and reducing distress in research animals. The following suggestion list is the distillate of many diverse opinions rather than firm directions for the future and is presented in no particular order for the reader's consideration: • Are there molecular or other markers of distress (e.g., fMRI and PET scans of blood flow through the brain)
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From page 88... ...
The absence of a consensus definition of distress affects the evaluation of distress and its impact on animal welfare in veterinary, scientific, and legislative contexts; integrative research approaches could be immensely helpful in this area. • The development of possible distress predictors could serve as the basis for a predictive scoring system for laboratory animals, similar to the system used for the severity of illness in human intensive care units (Knaus et al.
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From page 89... ...
• Are there established parameters for a truly optimal husbandry sys tem for each species of laboratory animal and for the genetic lines within those species? Animal care facility managers may wonder, for example, if it is more humane to disturb mice that normally sleep in the daytime for daily health assessments versus observ
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From page 90... ...
Well-trained, competent, and attentive research and animal care personnel are crucial in providing relief from unintended distress that originates from the care and use of laboratory animals.
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From page 91... ...
publish research pertaining to animal welfare, the highly specialized nature of the field makes it difficult for the larger scientific community to remain informed about recent advances and ongoing debates. Biomedical research journals should be more open to submissions from sci entists whose research focuses on animal welfare issues so that concerns about research interference or unjustified expenses can be debated on scientific, ethical, or regulatory grounds.
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From page 92... ...
2006. Newcastle Consensus Meeting on Carbon Dioxide Euthanasia of Laboratory Animals.
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From page 93... ...
Risk prediction of hospital mortality for critically ill hospitalized adults. Chest 100(6)
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