Health Effects of Beryllium Exposure A Literature Review (2007) / Chapter Skim
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5 Assessment of Other Health End Points
5 Assessment of Other Health End Points
Pages 70-72
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From page 70... ...
This chapter completes the charge for the first report by examining the literature relevant to determining whether inhaled beryllium has systemic health effects other than CBD and cancer that might be critical end points for use in deriving health-based standards. The focus is on studies of reproductive and developmental effects because these are often sensitive end points.
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From page 71... ...
Thus, beryllium exposure early in pregnancy when blastocysts are supported only by uterine secretions did not interfere with implantation, and exposure later in pregnancy after formation of the placenta did not appear to affect in utero development. Developmental effects occurred in pregnant rats after intratracheal injection of beryllium oxide or beryllium chloride (Selivanova and Savinova 1986)
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From page 72... ...
OTHER EFFECTS Extrapulmonary effects of beryllium compounds are not common and most often secondary to severe lung disease or related to extra-pulmonary granulomatous lesions in humans. Systemic effects of beryllium are generally observed only at high doses in animals.
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