Acute Exposure Guideline Levels for Selected Airborne Chemicals Volume 6 (2008) / Chapter Skim
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Pages 173-176
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Animal data also reflect the latency of severe or lethal effects observed in humans exposed to nickel carbonyl. Data describing nonlethal effects in test animals are limited to the demonstration of a nickel carbonyl-induced hyperglycemia in rats following 15-minute inhalation exposure to nickel carbonyl at or near LC50 values.
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From page 174... ...
. It has also been shown that pulmonary edema and chemical pneumonitis are characteristic of severe nickel carbonyl poisoning (Shi 1994b)
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From page 175... ...
Species Variability Generally, the lethality values presented in Section 3.1 for various species suggest that smaller species may be more sensitive to the lethal effects of nickel carbonyl. Based upon data for rats, mice, and cats, Kincaid et al.
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From page 176... ...
6.2. Summary of Animal Data Relevant to AEGL-2 Animal data regarding serious but nonlethal effects of acute inhalation exposure to nickel carbonyl were limited to studies examining the developmental toxicity of nickel carbonyl in Syrian hamsters (Sunderman et al.
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