Identification of Research Needs Relating to Potential Biological or Adverse Health Effects of Wireless Communication Devices (2008) / Chapter Skim
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In Vivo and In Vitro Studies in Experimental Model Systems
In Vivo and In Vitro Studies in Experimental Model Systems
Pages 37-44
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From page 37... ...
Well-designed studies in experimental biological models permit the precise quantification of exposure levels, generate essential dose-response data, provide the opportunity to eliminate many external variables that could confound or otherwise alter responses to RF fields, and support comparisons of RF responses to those of chemical and other physical agents using large historical databases in which the effects of those agents have been evaluated in biological models with known ability to predict human responses. Experimental studies can also be designed to include specific endpoint evaluations that can generate important data concerning possible biological mechanisms of RF action.
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From page 38... ...
In consideration of the size and strength of the emerging database for studies of the potential carcinogenicity and general toxicity of RF fields, and the quality of the studies that have been and are being conducted, there appears to be only limited value to be gained by initiating additional oncogenicity studies using standard-bred animal models until ongoing studies have been completed. Following completion of these studies, a "weight-of-the-evidence" analysis can be conducted (for example, using criteria established by the International Agency for Research on Cancer)
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From page 39... ...
Furthermore, the majority of experimental studies designed to identify genotoxic effects of exposure to RF fields have not found significant mutagenic or clastogenic activity in any model system that is in broad general use for genetic toxicology evaluations. On this basis, most investigators in the field agree that no compelling body of evidence exists to support the hypothesis that RF fields are genotoxic.
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From page 40... ...
. Cancer-Related Endpoints: Other Although substantial experimental data are emerging that can be used to evaluate the possible oncogenicity of RF fields, a number of potentially critical cancer-related endpoints have received only very limited study. These include: • Possible influences of RF exposure on the structure and function of the immune system.
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From page 41... ...
investigations of alterations in gene and protein expression in cells exposed to RF fields. Because no reproducible effects of RF exposure on cancer-related endpoints have yet been identified, genome-wide and proteome-wide screening studies can provide an unbiased (although untargeted)
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From page 42... ...
Following completion of this set of empirical studies, further progress in the evaluation of the possible health effects of RF exposure will depend on the conduct of hypothesis-driven investigations of putative mechanisms of RF action. At the present time, no generally accepted biological or molecular mechanism has been identified through which RF exposure may impact disease processes.
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From page 43... ...
Although genetic toxicology studies have failed to identify potential RF health effects (in part due to lack of replication of findings from key positive studies) , additional genetic toxicology studies may be warranted should evidence of oncogenicity be identified in any of the ongoing chronic toxicity/oncogenicity bioassays of RF fields in laboratory animals, or in any future studies to be performed using genetically engineered animal models.
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From page 44... ...
6. In addition to cancer-related endpoints, data gaps exist in a number of other areas of toxicology in which knowledge is essential to support a complete evaluation of the possible health effects of RF exposure.
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