Knowing What Works in Health Care A Roadmap for the Nation (2008) / Chapter Skim
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Appendix E: Examples of ECRI Institute and Hayes, Inc., Quick Turnaround Reports
Appendix E: Examples of ECRI Institute and Hayes, Inc., Quick Turnaround Reports
Pages 205-230
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Vaccines for Prevention of Cervical Cancer. To prepare this Hotline Response we consulted a number of information resources.
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against HPV strains 16 and 18, which are the strains responsible for 70% of cases of cervical cancer. This vaccine has been tested in 1,113 women for over two years.
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Documents presented to the committee and final approval documents can be viewed through the Web sites listed in section 6 of the Search Summary. Recent Clinical Literature Our searches identified 14 randomized, controlled trials (RCTs)
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• persistent cervical HPV infection was 95.1% • related cytological abnormalities was 92.9% Please be aware that the above opinions are based upon review of abstracts of published articles and, therefore, no firm conclusions are offered. Because abstracts do not always accurately reflect the methods and findings of the full-length article or the limits on interpreting the published data, the reader is strongly encouraged to obtain the relevant articles before reaching conclusions about this technology.
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Technical articles are also excluded unless they include clinical trial results. In writing the Hotline Response analysts screen the Bibliography for references relevant to the topic, and these are provided below in the narrower list of Selected References.
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Efficacy of a bivalent L1 viruslike particle vaccine in prevention of infection with human papillomavims types 16 and 18 in young women: a randomised controlled trial. Lancet.
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Advances in cervical cancer screening and human papillomavirus vaccines. J Br Menpause Soc.
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Preventing cervical cancer by vaccinating against HPV. Nurs Times.
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[Preventive vaccines and immunotherapy clinical trials against cervical cancer]
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[Human papillomavirus and cervical cancer: presence and future of vaccination]
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For all search results, click on the title to access the document. Results: There were no documents mentioning HPV vaccines; however, there were numerous documents on other issues concerning HPV and cervical cancer.
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AND "vaccine* "; papillomavirus; "cervix neoplasms" OR "cervical intraepithelial neoplasms" Results: There were no documents mentioning HPV vaccines; however, there were numerous documents on other issues concerning HPV and cervical cancer.
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. • National Cervical Cancer Coalition.
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The clinical studies described the use of PRP for various orthopedic procedures, including tibial osteotomy, foot and ankle surgery, total ankle arthroplasty, Charcot's foot reconstruction, total knee arthroplasty, and lumbar fusion. Regulatory Agency Information Administration of PRP is a procedure and is, therefore, not subject to regulation by the Food and Drug Administration (FDA)
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PRP contains growth factors that maybe useful in healing nonunion fractures. Also known as platelet gel, or platelet concentrate, PRP is a blood product that is created by isolating and concentrating platelets from the patient's own blood.
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com/viewarticle/4439021 comprehensive search of the Internet did not return any information regard A ing evidence-based practice guidelines or ongoing clinical trials for PRP for bone healing and fusion. Search Results with Abstracts January 15, 2007 MEDLINE, EMBASE Search terms: latelet concentrate, platelet-rich plasma combined with spinal, p fusion, bone AND fusion, bone healing, orthopedic surgery, platelet concentrate, platelet gel combined with orthopedic sur gery, bone healing, spinal fusion Search limits: English-language human clinical trials and review articles pub lished in the last 5 years
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2005 Jun. Platelet-rich plasma and platelet gel: a review.
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However, to our disappointment, not many well-designed scientific studies are available, and many anecdotic stories exist, whereas questions remain to be answered. We therefore decided to study periopera tive blood management in more detail with emphasis on the application and production of autologous platelet gel and the use of fibrin sealant.
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:364-72, 2006 Feb. Evaluation of bone healing enhancement by lyophilized bone grafts supple mented with platelet gel: a standardized methodology in patients with tibial osteotomy for genu varus.
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bibbo.christopher@marshfieldclinic.org Adjuvant use of autologous platelet concentrate (APC) to assist bone healing in foot and ankle surgery has not been reported.
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CONCLUSION: Autologous concentrated growth factors appear to make a significant positive difference in the syndesmosis union rate in total ankle replacements. Publication Types: Comparative Study PMID: 16221457 [PubMed - indexed for MEDLINE]
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Despite this, we showed that platelet gel failed to enhance fusion rate when added to autograft in patients undergoing instrumented posterolateral spinal fusion. The authors do not recommend the use of platelet gel to supplement autologous bone graft during instrumented posterolateral spinal fusion.
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charcotking@yahoo.com review of current knowledge of autologous growth factors as used in foot A and ankle surgery is presented. This knowledge is clinically correlated with 50 Charcot's foot reconstruction patients who had diabetes and who were randomized to a platelet-rich plasma (PRP)
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METHODS: A consecutive series of patients between 1996 and 1999 undergoing one- and two-level TLIFs with AGF were compared with a consecutive series of TLIF patients who did not receive AGF. Sixty-two con trol subjects who did not receive AGF and 22 patients who received an AGF platelet gel were compared after 41 and 34 months of follow-up, respectively.
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36(l) :28-35, 2004 Mar Comparison of methods for point of care preparation of autologous platelet gel.
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