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Biologic Markers in Pulmonary Toxicology (1989) / Chapter Skim
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7 Conclusions and Recommendations
Pages 133-136

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From page 133...
... Since the drafting of this report itself, research on the functions of adhesive proteins, such as fibronectin and laminin, and of cellular integrins, which bind to receptor sites on these proteins, has exploded, providing potential new markers for following the progress of normal and abnormal processes of repair of pollutantcaused damage. Listed below are recommendations for research that offers the best opportunity to enhance the use of biologic markers in the study of environmental health effects on the respiratory tract.
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From page 134...
... 2. Further research is required on the role of nonspecific airway reactivity in identifying persons susceptible to environmental agents and on the role of airway reactivity in the natural history of chronic obstructive pulmonary disease (COPD)
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From page 135...
... Labeling indexes determined by autoradiography are not adequate for describing cell kinetics. New techniques, such as a combination of autoradiography with morphometry to measure cell pool sizes before and after injury, can make it possible to determine changes in the entire cell cycle during lung injury.
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Key Terms

  • biologic markers
  • airway reactivity
  • pollutant exposure
  • environmental pollutants
  • specific sites

  • cell kinetics
  • inhaled pollutants
  • lung injury
  • cell function
  • environmental agents

  • specific chemicals
  • cell cycle
  • nasal ravage
  • physical characteristics
  • genetic techniques

  • readily accessible
  • formation offers
  • macromolecular adduct
  • growth factors
  • respiratory function

  • describing cell
  • transient changes
  • assessed initially
  • arachidonic acid
  • characterize types

  • changes found
  • cell pool
  • interspecies studies
  • increased risk
  • pathologic changes


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