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Pages 1-6

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From page 1...
... Although the numerous regulations, policies, and guidelines that govern animal use in research in the United States address distress and pain jointly, from a scientific perspective the two concepts are quite distinct. According to the International Association for the Study of Pain, pain in humans is "an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage" (IASP 1979)
From page 2...
... APPROACH TO THIS STUDY The committee collected and evaluated scientific evidence from peerreviewed published literature, evidence-based veterinary practices, and expert opinions, and defined a consistent terminology in the Glossary and Chapter 1. The committee examined the occurrence of pain in vertebrates alone, for several reasons: (1)
From page 3...
... and behavioral changes observed correlates closely with the intensity of pain. Current best practices to assess pain entail a structured clinical examination combined with solid knowledge of the normal appearance and behavior of the species.
From page 4...
... However, lack of knowledge of drug effects and doses in many mammalian and especially nonmammalian species, and the potentially confounding effects of analgesics and anesthetics on study variables, limit effective pain management. Given the impact of better animal welfare on science as well as the growing public interest in the treatment of laboratory animals, federal agencies and foundations that support biomedical and behavioral research should make funds available for pain-related studies (see also NRC 2008)
From page 5...
... • It is necessary to educate investigators, veterinarians, and animal care staff about the basic physiologic principles, causes, signs, and availability of diverse treatment options and potential deleterious effects of those treatments on pain. As the field of pain medicine benefits from new insights and methods of prevention and treat ment for humans, so should laboratory animals benefit from the research for which they are a currently indispensable underpinning.

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